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Butylone

Butylone molecule structureButylone molecule structure
β-keto-N-methylbenzodioxolylbutanamine
βk-MBDB, B1, bk-MBDB
Psychoactive Class
Chemical Class

Butylone is a synthetic entactogen and stimulant of the substituted cathinone class.citation needed It is the β-keto analogue of MBDB and bears a structural relationship to methylone analogous to that between MBDB and MDMA. First synthesized in 1967, it remained academically obscure until 2005 when it emerged as a designer drug. Butylone is frequently sold as a substitute or counterfeit for MDMA and methylone under the collective street label "Molly," though its subjective effects are not identical to either substance.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~30 mg
Light30-70 mg
Moderate70-120 mg
Strong120-200 mg
Heavy200+ mg

Duration

Onset15-60 minutes
Peak60-120 minutes
Offset60-120 minutes
After Effects4-12 hours
Total3-5 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Butylone offers an effect profile akin to that of other triple monoamine releasers such as MDMA, but the entactogenic effects appear less pronounced and meaningful.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2
Mecke(ME)
white → yellow2 → orange2
Mandelin(MD)
yellow2 → brown2 → black3
Liebermann(LB)
white → yellow2 → green1 → brown2
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Pharmacology

Pharmacodynamics

Butylone acts as a mixed reuptake inhibitor and releasing agent at the serotonin, norepinephrine, and dopamine transporters, increasing extracellular monoamine levels.citation needed Its activity profile is weighted toward reuptake inhibition, though it retains relatively robust monoamine releasing capabilities. Relative to methylone, butylone has approximately 4-fold lower affinity for the norepinephrine transporter, while its serotonin and dopamine transporter affinities are comparable.

Pharmacokinetics

Butylone is metabolized through three primary pathways. The most prominent are demethylenation followed by O-methylation and β-ketone reduction, with N-dealkylation occurring less frequently.1 The most commonly observed metabolite in human urine is the 4-OH-3-MeO form.1 Hydroxyl-containing metabolites are excreted as conjugates in urine.citation needed

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPAlcoholDXMDissociativesMAOIsMDMAMXENBOMe compoundsSNRIsSSRIsSerotonin releasersStimulantsTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
With prolonged repeated use, many effects may weaken, so users may need larger doses to obtain similar results.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Moderate

Chronic use is considered moderately addictive with a high potential for abuse and may cause psychological dependence.citation needed Cravings may develop with regular use, and users may experience difficulty stopping once a pattern of use has been established.

Physical

Low

Withdrawal effects may occur when regular users suddenly stop, though these appear to primarily involve neurotransmitter depletion symptoms such as anxiety, depression, cognitive fatigue, and irritability rather than severe physical withdrawal.citation needed

Psychosis Risk

Abuse at high dosages for prolonged periods can potentially result in stimulant psychosis presenting with paranoia, hallucinations, or delusions. Based on data from related amphetamine-class stimulants, approximately 5-15% of users who develop stimulant psychosis may not fully recover.2 Psychosis is unlikely with occasional use at moderate doses.

History & Culture

Butylone was first synthesized in 1967 by Koeppe, Ludwig, and Zeile, who documented their work in a paper from that year. Following its initial synthesis, the compound remained an obscure product of academic chemistry for nearly four decades, receiving little attention outside of laboratory

Legality

By Country

Illegal10
United States flagUnited StatesSchedule I
Austria flagAustriaIllegal (analog/blanket ban)
Brazil flagBrazilIllegal
Canada flagCanadaIllegal
Israel flagIsraelIllegal
Japan flagJapanIllegal
Norway flagNorwayIllegal
Poland flagPolandIllegal
Sweden flagSwedenSchedule I (Narcotic)
Switzerland flagSwitzerlandIllegal
Controlled / restricted4
China flagChinaControlled substance
Finland flagFinlandRestricted
Germany flagGermanyAnlage II BtMG
United Kingdom flagUnited KingdomClass B
Not scheduled1
France flagFranceStupéfiant

References

Source Pages

  1. Bluelight: Butylone Experiences
  2. Bluelight: The Big & Dandy bk-MBDB (Butylone) Thread
  3. Erowid
  4. Erowid: Butylone Vault
  5. Erowid: Butylone Vault
  6. Isomer Design (TiHKAL/PiHKAL)
  7. IsomerDesign: Cathinones Report
  8. PsychonautWiki
  9. TripSit Factsheets
  10. UNODC: Global SMART Programme 2013
  11. Wikipedia

Citations

  1. Kei Zaitsu, Munehiro Katagi, Hiroe T Kamata, Tooru Kamata, Noriaki Shima, Akihiro Miki, Hitoshi Tsuchihashi, & Yasushige Mori. (July 2009). Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine. Forensic Science International, 188(1–3), 131–139. https://doi.org/10.1016/j.forsciint.2009.04.00112
  2. Steven J Shoptaw, Uyen Kao, & Walter Ling. (2009). Treatment for amphetamine psychosis. https://doi.org/10.1002/14651858.cd003026.pub31
  3. PubChem CID 56843046 compound properties. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/butylone/property/IUPACName,Title,MolecularFormula,InChIKey,CanonicalSMILES/JSON1
  4. PubChem CID 56843046 synonyms. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/56843046/synonyms/JSON12
  5. RIS - Neue-Psychoaktive-Substanzen-Verordnung § 1 - Bundesrecht konsolidiert, Fassung vom 27.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007642&FassungVom=2026-08-27&Paragraf=1&Artikel=&Anlage=&Uebergangsrecht=&ShowPrintPreview=True1
  6. RIS - Neue-Psychoaktive-Substanzen-Verordnung Anlage II - Bundesrecht konsolidiert, Fassung vom 27.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=2&Artikel=&FassungVom=2026-08-27&Gesetzesnummer=20007642&Paragraf=&ShowPrintPreview=True&Uebergangsrecht=1
  7. BGBl. II Nr. 106/2024 Anlage II - NPSV generic chemical classes. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
  8. RIS - Neue-Psychoaktive-Substanzen-Gesetz § 2 - Bundesrecht konsolidiert, Fassung vom 27.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007605&FassungVom=2026-08-27&Paragraf=2&Artikel=&Anlage=&Uebergangsrecht=&ShowPrintPreview=True1
  9. RIS - Neue-Psychoaktive-Substanzen-Gesetz § 4 - Bundesrecht konsolidiert, Fassung vom 27.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007605&FassungVom=2026-08-27&Paragraf=4&Artikel=&Anlage=&Uebergangsrecht=&ShowPrintPreview=True1
  10. RIS - Neue-Psychoaktive-Substanzen-Gesetz § 5 - Bundesrecht konsolidiert, Fassung vom 27.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007605&FassungVom=2026-08-27&Paragraf=5&Artikel=&Anlage=&Uebergangsrecht=&ShowPrintPreview=True1

Further Reading

  1. Baumann et al. 2019 - Butylone and pentylone neuropharmacology (DOI)
  2. Cozzi et al. 1999 - Beta-ketoamphetamine transporter inhibition (DOI)
  3. Leong et al. 2020 - Synthetic cathinones induce cell death in dopaminergic cells (DOI)
  4. Zaitsu et al. 2009 - Butylone metabolism study

Article Status

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    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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Recent changes8 human edits · latest

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29 August 2026

  1. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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