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4-HO-MET

4-HO-MET molecule structure4-HO-MET molecule structure
4-Hydroxy-N-methyl-N-ethyltryptamine
Metocin, Methylcybin, Colour
Psychoactive Class
Chemical Class
Tryptamine

4-HO-MET is a synthetic psychedelic tryptamine first synthesized by Alexander Shulgin and documented in his 1997 book TiHKAL.citation needed Structurally related to psilocin, it produces effects through serotonin receptor agonism. Users typically describe it as more recreational than psilocybin mushrooms, characterized by vivid colorful visuals with a less mentally intense headspace. Reports of human use emerged in the late 2000s following its appearance on the research chemical market. Very little data exists regarding its toxicity profile.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold2-8 mg
Light10 mg
Moderate10-15 mg
Strong20+ mg
Heavy25 mg

Reported active doses vary widely between individuals; some report heavy effects near 17 mg while others report light effects at 30 mg, which has been attributed to differences in metabolism, batch quality, and salt form. Nausea is reported to be less prominent than with psilocybin mushrooms and may be reduced by dosing on an empty stomach.

Duration

Onset15-40 minutes
Come Up30-60 minutes
Peak2-3 hours
Offset1-1.5 hours
After Effects2-12 hours
Total4-6 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

The physical effects of 4-HO-MET can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:

NauseaPupil dilation

Cognitive

The cognitive effects of 4-HO-MET are described by many as somewhat relaxing yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects. The most prominent of these typical effects generally include:

Visual

A noteworthy aspect regarding this compound is that at sub-psychedelic doses, it appears to still produce visual effects without any accompanying cognitive effects or "head space."

Distortions

As for visual distortions and alterations, the effects experienced are detailed below:

Enhancements

4-HO-MET presents a full and complete array of possible visual enhancements which generally includes:

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of psilocin (4-HO-DMT) and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-HO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of both LSD and psilocybin.

Hallucinatory States

4-HO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Transformations

Auditory

The auditory effects of 4-HO-MET are common in their occurrence and exhibit a full range of effects which commonly include:

Forked from Subjective Effect Documentation work byJosie Kins September 2015.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2 → brown2 → black3
Mecke(ME)
white → black3
Mandelin(MD)
yellow2 → black3
Liebermann(LB)
white → yellow2 → green2 → black3
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Pharmacology

Pharmacodynamics

4-HO-MET primarily acts as a partial agonist at the serotonin 5-HT2A receptor1 with high affinity and a maximum activation of 72%, an interaction believed to underlie its psychedelic effects. It also acts as an agonist at 5-HT1A, 5-HT2B, and 5-HT2C receptors and shows high affinity for the serotonin transporter with modest reuptake inhibition, though direct receptor agonism is considered the more significant contributor to its effects. Additional lower-affinity binding has been observed at histamine H1, TAAR1, dopamine D2 and D3, and α1A and α2A adrenergic receptors.1 4-HO-MET does not possess monoamine releasing properties.1

Pharmacokinetics

4-HO-MET is metabolized hepatically. In vivo studies in humans have identified four metabolitescitation needed resulting from hydroxylation, glucuronidation of the parent compound, and glucuronidation of an N-oxide metabolite. In vitro analysis using pooled human liver microsomes has revealed a broader metabolic profile of twelve metabolites2, with additional transformation pathways including dihydroxylation, N-oxide formation, demethylation, desethylation, and carboxylic acid formation. Three of the monohydroxylated metabolites were modified at the benzene ring of its indole structure. 4-AcO-MET is believed to function as an ester prodrug that is hydrolyzed to 4-HO-MET in the body.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to the effects of 4-HO-MET develops almost immediately after ingestion. Notably, 4-HO-MET appears to be more amenable to redosing than many other psychedelics, with reports suggesting that taking an additional dose 1.5-2.5 hours after initial administration can restore or intensify effects without showing strong evidence of acute tolerance buildup.
Baseline Reset
7 days
Half Tolerance
Approximately 3 days
Cross Tolerance

All psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

4-HO-MET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating and is not known to be associated with compulsive use.

Physical

Extremely Low

Physical dependence is extremely unlikely.citation needed

Toxicity

Cardiovascular

Tachycardia and elevated blood pressure may occur during acute intoxication; serious cardiovascular complications are hypothetical and would be expected primarily at overdose levels.

Renal

Kidney damage is a hypothetical risk at overdose levels based on pharmacological considerations; no documented cases of renal toxicity from typical use.

Psychosis Risk

There are reports of very high doses leading to drug-induced psychosis. A formal case report described a teenager who used approximately 100 mg, resulting in severe psychotic symptoms including visual hallucinations, paranoid delusions, sensation of insects under the skin, and dangerous behavior requiring week-long hospitalization. Psychotic symptoms typically resolve with supportive care, though paranoid ideation may persist for several days. At common doses, psychotic reactions are uncommon.

Seizure Risk

Like other psychedelics, 4-HO-MET is believed to lower the seizure threshold and may increase the likelihood of seizures in those with personal susceptibility or family history of epilepsy. This is not considered a risk in healthy people at typical doses. Seizures at overdose levels are conceivable but remain hypothetical.

History & Culture

Discovery and Early Research

4-HO-MET was first synthesized by American chemist Alexander Shulgin during the 1970s.citation needed The compound was subsequently described in the scientific literature by David Repke and colleagues in 1981. Shulgin later documented 4-HO-MET in his 1997 book TiHKAL (Tryptamines

Trip Reports

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Legality

International

1961 Single Convention: 4-HO-MET is not individually scheduled.

1971 Convention on Psychotropic Substances: 4-HO-MET is not individually scheduled.

1988 Convention: 4-HO-MET is not listed in precursor Tables I or II.

By Country

Illegal10
Australia flagAustraliaIllegal (analog/blanket ban)
Austria flagAustriaIllegal (analog/blanket ban)
Belgium flagBelgiumIllegal
Bulgaria flagBulgariaIllegal
Hungary flagHungaryIllegal (analog/blanket ban)
Japan flagJapanIllegal
Lithuania flagLithuaniaIllegal
Poland flagPolandIllegal
Sweden flagSwedenIllegal
United Kingdom flagUnited KingdomIllegal
Controlled / restricted5
Finland flagFinlandRestricted
Germany flagGermanyRestricted
Portugal flagPortugalRestricted
Slovakia flagSlovakiaRestricted
Switzerland flagSwitzerlandRestricted
Not scheduled2
United States flagUnited StatesUnscheduled
Canada flagCanadaNot scheduled

References

Source Pages

  1. Drug Users Bible by Dominic Milton Trott
  2. Erowid
  3. Isomer Design (TiHKAL/PiHKAL)
  4. IsomerDesign: 4-HO-MET in PiHKAL
  5. PsychonautWiki
  6. Shulgin & Shulgin 1997: TiHKAL #21
  7. The Drug Classroom
  8. The Drug User's Bible: 4-HO-MET
  9. TripSit Factsheet: 4-HO-MET
  10. TripSit Factsheets
  11. Wikipedia

Citations

  1. Anna Rickli, Matthias C. Hoener, & Markus E. Liechti. (2016-08). Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European Neuropsychopharmacology, 26(8), 1327–1337. https://doi.org/10.1016/j.euroneuro.2016.05.00112345678910111213141516171819202122
  2. Pia Simona Bruni, K. E. Grafinger, S. Nussbaumer, S. König, S. Schürch, & W. Weinmann. (2018-09). Study of the in vitro and in vivo metabolism of 4-HO-MET. Forensic Science International, 290, 103–110. https://doi.org/10.1016/j.forsciint.2018.06.0371
  3. Álvaro José Palma-Conesa, Mireia Ventura, Laia Galindo, Francina Fonseca, Marc Grifell, Pol Quintana, Iris Fornís, Carlos Gil, Magí Farré, & Marta Torrens. (2017). Something New about Something Old: A 10-Year Follow-Up on Classical and New Psychoactive Tryptamines and Results of Analysis. 49(4), 297–305. https://doi.org/10.1080/02791072.2017.13207321
  4. Débora González, Mireia Ventura, Fernando Caudevilla, Marta Torrens, & Magí Farré. (2013). Consumption of new psychoactive substances in a Spanish sample of research chemical users. 28(4), 332–340. https://doi.org/10.1002/hup.23231
  5. Helander A, Beck O, Hägerkvist R, & Hultén P. (2013). Identification of novel psychoactive drug use in Sweden based on laboratory analysis--initial experiences from the STRIDA project. 73(5), 400-406. https://doi.org/10.3109/00365513.2013.7938171
  6. PubChem Compound CID 21786582, computed properties. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/21786582/property/IUPACName,MolecularFormula,MolecularWeight/JSON12
  7. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, commencement and classification guidance. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
  8. Customs (Prohibited Imports) Regulations 1956, Compilation No. 147 (13 July 2026), drug definition and Schedule 4. legislation.gov.au (n.d.). https://www.legislation.gov.au/F1996B03651/2026-07-13/2026-07-13/text/original/epub/OEBPS/document_1/document_1.html1
  9. Criminal Code Regulations 2019, Compilation No. 6 (13 December 2025), Schedule 1. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-12-13/2025-12-13/text/original/epub/OEBPS/document_1/document_1.html1
  10. Criminal Code Act 1995, Compilation No. 174 (30 June 2026), sections 301.1 and 301.9. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_2/document_2.html1

Further Reading

  1. Kjellgren & Soussan 2011: Phenomenological Study of 4-HO-MET

Article Status

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Recent changes8 human edits · latest

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1 August 2026

  1. Lyrea · Updated the article

13 July 2026

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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