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4-HO-EPT

This article is a stubmissing:
Subjective Effects
Pharmacology
Tolerance
History & Culture
4-HO-EPT molecule structure4-HO-EPT molecule structure
4-Hydroxy-N-ethyl-N-propyltryptamine
Eprocin
Psychoactive Class
Chemical Class
Tryptamine

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~10 mg
Light10-20 mg
Moderate20-30 mg
Strong30-50 mg
Heavy50+ mg

Duration

Onset30-60 minutes
Peak1-2 hours
Offset1-2 hours
Total3-7 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → brown2
Mecke(ME)
white → green3 → black3
Mandelin(MD)
yellow2 → green2
Liebermann(LB)
white → orange1 → brown3 → black3
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Pharmacology

Pharmacology not written up yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Higher doses may increase adverse effects, including possible addiction-related concerns, but 4-HO-EPT-specific addiction risk has not been characterized.

Toxicity

Lethal Dosage

The exact toxic dose is described as unknown, and recreational toxicity and long-term health effects are said not to have been scientifically studied.

gastrointestinal

Nausea is listed among physical effects.

Psychosis Risk

Moderate

Psychosis risk is specifically warned for lithium combinations and may be increased by cannabis or stimulant combinations; delusion is also listed as a cognitive effect.

Seizure Risk

Moderate

Lithium is warned to significantly increase psychosis and seizure risk, and tramadol may lower the seizure threshold enough for psychedelics to trigger seizures in susceptible people.

History & Culture

History & Culture not written up yet

Trip Reports

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Legality

By Country

Illegal4
United States flagUnited StatesIllegal (analog/blanket ban)
Germany flagGermanyIllegal (analog/blanket ban)
Switzerland flagSwitzerlandIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomIllegal

References

Source Pages

  1. Bluelight: The Big & Dandy 4-HO-EPT Thread
  2. Erowid: 4-HO-EPT Experience Vault
  3. Isomer Design (TiHKAL/PiHKAL)
  4. PsychonautWiki
  5. TripSit Factsheets
  6. Wikipedia

Citations

  1. Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
  2. Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 2 Begriffsbestimmungen. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__2.html1
  3. Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 3 Unerlaubter Umgang mit neuen psychoaktiven Stoffen. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1
  4. Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 4 Strafvorschriften. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__4.html1
  5. Verordnungen zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes (NpSG) — Bundesministerium für Gesundheit. bundesgesundheitsministerium.de (n.d.). https://www.bundesgesundheitsministerium.de/service/gesetze-und-verordnungen/detail/verordnung-zur-aenderung-der-anlage-des-neue-psychoaktive-stoffe-gesetzes-und-von-anlagen-des-btmg1
  6. Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes — Text der Bundesregierung. bundesgesundheitsministerium.de (n.d.). https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/3_Downloads/Gesetze_und_Verordnungen/GuV/N/NpSG_BtMG_VO_AEnd_Anlagen.pdf1
  7. Deutscher Bundestag Drucksache 18/8579 — Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe. dserver.bundestag.de (n.d.). https://dserver.bundestag.de/btd/18/085/1808579.pdf1
  8. PubChem CID 138454310: 4-HO-Ept. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/138454310/property/IUPACName,Title,CanonicalSMILES/JSON1
  9. PubChem PUG REST synonyms for CID 138454310. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/138454310/synonyms/JSON123
  10. Betäubungsmittelverzeichnisverordnung (BetmVV-EDI), Stand am 13. März 2026, Anhang 6, Verzeichnis e Nr. 266. fedlex.data.admin.ch (n.d.). https://fedlex.data.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20260313/de/html/fedlex-data-admin-ch-eli-cc-2011-363-20260313-de-html-3.html1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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