4-HO-DiPT
4-HO-DiPT is a psychedelic substance of the tryptamine class structurally related to psilocin.1 First described in scientific literature by 1977 and later detailed by Alexander Shulgin in TiHKAL (1997)citation needed, it is distinguished by its unusually rapid onset, short duration, and steep dose-response curve. Idiosyncratic physical effects such as muscle tremors and bodily malaise have been noted. It remains relatively uncommon with a limited history of human use and poorly understood toxicity.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Reported to have an especially steep dose-response curve and narrow dose range; doses below 10 mg have produced few to no effects, while doses above 20 mg have generally not been tested due to the intensity of effects.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
4-HO-DiPT acts as a serotonin receptor agonist with primary activity at the 5-HT2A receptor2, where it is thought to function as a partial agonist and through which its psychedelic effects are believed to be mediated. It also activates 5-HT2B receptors3 and, with comparatively lower potency, 5-HT2C receptors, though findings on the degree of 5-HT2A versus 5-HT2C selectivity vary between studies.citation needed The substance may additionally act as a serotonin reuptake inhibitor, although its potency at the serotonin transporter has been inconsistent across studies. In a transfected HEK293-cell screen, 4-HO-DiPT showed no measurable binding within the tested range at rat or mouse trace amine-associated receptor 1 (TAAR1), and only negligible activation of human TAAR1 in a functional assay.
Pharmacokinetics
Human pharmacokinetic evidence is limited to 4-HO-DiPT formed after subcutaneous administration of its prodrug luvesilocin (RE104), rather than direct administration of 4-HO-DiPT. In a randomized phase 1 study of single 5–40 mg subcutaneous RE104 doses, 4-HO-DiPT appeared rapidly in plasma, with a median Tmax of 1.0–1.25 hours and a mean elimination half-life of 2.72–4.12 hours across dose groups.4 Exposure appeared linear over the tested doses.4 Because every reported value follows the prodrug rather than direct 4-HO-DiPT administration, these figures should not be generalized to oral 4-HO-DiPT or to other formulations.citation needed
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Serotonergic psychedelics5
Harm Potential
Addiction & Dependence
Psychological
Extremely Low4-HO-DiPT is not regarded as habit-forming, and repeated use may reduce a person's desire to take it. Similar to most tryptamine psychedelics, it is considered self-regulating.citation needed
Physical
Extremely LowNo physical dependence has been reported. As a tryptamine psychedelic, it does not produce physical withdrawal symptoms.citation needed
Psychosis Risk
Delusions are listed among possible cognitive effects. As with other psychedelics, adverse psychological reactions may become more likely at higher doses, though specific psychosis risk data for this substance has not been established.
Seizure Risk
Seizure risk has not been specifically studied for this substance.
History & Culture
4-HO-DiPT was first described in the scientific literature in 1977, with its synthesis published by chemist David B. Repke.1 Two decades later, Alexander Shulgin investigated the substance's effects in humans and characterized it in his 1997…
Trip Reports
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Legality
By Country
References
Source Pages
Citations
- 4-HO-DiPT. Psychedelic Science Review (23 June 2022). https://psychedelicreview.com/compound/4-ho-dipt/1234
- Laura B. Kozell, Amy J. Eshleman, Tracy L. Swanson, Shelley H. Bloom, Katherine M. Wolfrum, Jennifer L. Schmachtenberg, Randall J. Olson, Aaron Janowsky, & Atheir I. Abbas. (April 2023). Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)2A Receptor (5-HT2AR), 5-HT2CR, 5-HT1AR, and Serotonin Transporter. J Pharmacol Exp Ther, 385(1), 62–75. https://doi.org/10.1124/jpet.122.0014541
- Grant C. Glatfelter, Marilyn Naeem, Duyen N. K. Pham, James A. Golen, Andrew R. Chadeayne, David R. Manke, & Michael H. Baumann. (April 2023). Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice. ACS Pharmacol Transl Sci, 6(4), 567–577. https://doi.org/10.1021/acsptsci.2c002221
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104: A Double-Blind, Randomized, Single Ascending Dose Placebo-Controlled Study. J Clin Psychopharmacol, 45(5), 441–453 (2025). https://doi.org/10.1097/jcp.000000000000204712
- Matthew W Johnson, Roland R Griffiths, Peter S Hendricks, & Jack E Henningfield. (2018). The Abuse Potential of Medical Psilocybin According to the 8 Factors of the Controlled Substances Act. Neuropharmacology, 142, 143-166. https://doi.org/10.1016/j.neuropharm.2018.05.0121
- Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista (1130/2014), current consolidated text. finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2014/11301
- Liite, VNa kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista, as amended by 650/2026. finlex.fi (n.d.). https://www.finlex.fi/api/media/statute-consolidated/1079343/media/8500.pdf1
- Huumausainelaki (373/2008), current consolidated text. finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2008/3731
- Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista (543/2008), current consolidated text with annexes I to V. finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2008/5431
- Anlage 1 NpSG (generic structural class definitions, including tryptamine-derived compounds). gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html12
Further Reading
Chadeayne et al. (2025). 4-Hydroxy-N,N-diisopropyltryptammonium hydrofumarate crystal structure
Drugs-Forum: 4-HO-DiPT Trip Reports
Glatfelter et al. (2023). Binding and functional activity of psilocin analogs at serotonin receptors
Kelly et al. (2024). Psychedelic tryptamine pharmacology and therapeutic potential
Repke et al. (1977). Psilocin analogs synthesis- Repke, D. B. et al. (1977). Psilocin analogs synthesis
Article Status
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13 July 2026
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Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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