Contents
Dosage & Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
Reagent Testing
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Pharmacology
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
LowAs a classical psychedelic tryptamine, 4-HO-DET is not considered to have significant abuse potential. Higher doses are more likely to produce adverse reactions and could theoretically involve addiction, although this has not been well documented for this compound.
Toxicity
No precise toxic dose has been established, as 4-HO-DET remains a research chemical with minimal documented human-use history.
Stomach and abdominal discomfort, appetite loss, and diuretic effects have been reported at typical doses, generally presenting as transient effects during the experience.
Increased blood pressure has been reported during intoxication.
Psychosis Risk
At very high doses (over 30 mg), reports describe reactions such as transient psychosis, depersonalization, mystical experiences, delirium, schizophrenia-like behavior, catatonia, and paranoia. Clinical studies found that in 50% of cases there was motor restlessness, aphasia, loss of concentration, and temporal and spatial disorientation, with extreme psychotic symptoms occurring more rarely and only at the highest doses.
History & Culture
Trip Reports
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Legality
By Country
References
Source Pages
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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