4-AcO-MiPT

4-Acetoxy-N-methyl-N-isopropyltryptamine

Mipracetin, O-Acetylmiprocin

Psychoactive Class

Chemical Class

4-AcO-MiPT is a synthetic psychedelic of the tryptamine class.¹ It is the acetylated form of 4-HO-MiPT and a higher homolog of 4-AcO-DMT, commonly hypothesized to act primarily as a prodrug for its hydroxylated counterpart, though whether it possesses innate activity of its own remains debated. Very little is known about its human pharmacology or toxicity. It remains relatively uncommon, with minimal history of human use, and is primarily acquired through online research chemical vendors.

Dosage & Duration

Dosage

Threshold~5 mg

Light10-15 mg

Moderate15-20 mg

Strong20-35 mg

Heavy35+ mg

Duration

Onset15-45 minutes

Come Up60-120 minutes

Peak1.5-3 hours

Offset1-2 hours

After Effects2-4 hours

Total4-8 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

Runny nose Watery eyes

Cognitive

The cognitive effects of 4-AcO-MiPT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating.

Enhancement of current mind state Connectivity of thought Feelings of fascination, importance and awe Time distortion Outrospection Déjà vu Removal of cultural filter Feelings of predeterminism Conceptual thinking Direct communication with the subconscious Ego suppression, loss and death Feelings of interdependent opposites Delusions States of unity and interconnectedness

Visual

Distortions

Tracers After images Texture repetition Colour shifting Scenery slicing

Enhancements

Increased visual acuity Enhancement of colour Enhanced pattern recognition

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, unimmersive in depth and consistent in intensity. The visuals have a very 'natural' feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory States

4-AcO-MiPT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.

Transformations

Auditory

The auditory effects of 4-AcO-MiPT are common in their occurrence and exhibit a full range of effects.

Enhancements Distortions Hallucinations

Adapted from the 4-HO-MiPT subjective effects documentation. 4-AcO-MiPT is the acetylated prodrug of 4-HO-MiPT and is reported to produce an effectively identical experience. Forked from Subjective Effect Documentation

by Josie KinsJuly 2014.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

4-AcO-MiPT is thought to act principally as a partial agonist at the serotonin 5-HT2A receptor, with its psychedelic effects believed to stem from this interaction. It is commonly hypothesized to also function as a prodrug for 4-HO-MiPT, its hydroxylated counterpart, although whether 4-AcO-MiPT possesses innate activity of its own remains debated.² Very little information on the human pharmacology of this substance is currently available.

Pharmacokinetics

4-AcO-MiPT may be metabolized into 4-HO-MiPT in the body, analogous to the conversion of psilocybin into psilocin.² Beyond this hypothesized deacetylation, specific details regarding the enzymes involved, bioavailability, or elimination half-life have not been characterized in published literature.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Lithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Tramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

AmphetaminesCannabisCocaineDiphenhydramine

TripSit

Tolerance

Full Tolerance

Develops almost immediately after ingestion.

Baseline Reset

7 days

Half Tolerance

Approximately 3 days

Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Not considered habit-forming; the desire to use typically decreases rather than increases with repeated consumption. Like most classical psychedelics, it demonstrates self-regulating properties.³⁴

History & Culture

4-AcO-MiPT is a synthetic psychedelic tryptamine² that remains relatively obscure within the broader landscape of psychoactive substances. Unlike many classical psychedelics with decades of documented use, this compound has accumulated very little history of human…

Trip Reports

Legality

By Country

United StatesUnscheduled (Federal Analogue Act may apply)

Not specifically scheduled under the Controlled Substances Act.¹² However, it may be considered an analogue of psilocin (4-HO-DMT), a Schedule I substance. Sale for human consumption or possession with intent to ingest could potentially be prosecuted under the Federal Analogue Act, though no such prosecutions have been documented.

GermanyNpSG (Controlled)

Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since July 18, 2019.⁶ Production, import with intent to market, administration to others, and trading are criminal offenses.⁷ Possession is prohibited but not subject to criminal penalties.⁸ Ordering may be considered incitement to place on the market.

SwedenIllegal (Health Hazard)

Classified as a health hazard under the Lagen om förbud mot vissa hälsofarliga varor (Act on the Prohibition of Certain Goods Dangerous to Health) since November 1, 2005.¹⁰ Listed in regulation SFS 2005:733, making both possession and sale illegal.

United KingdomClass A

Controlled as a Class A substance because it is an ester of 4-HO-MiPT, which falls under the tryptamine catch-all clause of the Misuse of Drugs Act 1971.¹¹ Class A carries the most severe penalties under UK law.

FinlandIllegal

Banned in December 2014 as part of a government regulation prohibiting over 100 psychoactive substances with no accepted medical use.

JapanControlled Substance

Designated as a controlled substance effective March 25, 2015 under Japanese drug control legislation.⁹

SwitzerlandPotentially Illegal

May be considered illegal under Buchstabe B of Swiss drug legislation as an ester analogue of 4-HO-MiPT, which is a controlled substance. Legal status depends on analogue interpretation.

References

Source Pages

Citations

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4-AcO-MiPT

4-Acetoxy-N-methyl-N-isopropyltryptamine

Mipracetin, O-Acetylmiprocin

Psychoactive Class

Psychedelic

Chemical Class

Tryptamine