4-AcO-MiPT

4-Acetoxy-N-methyl-N-isopropyltryptamine

Mipracetin, O-Acetylmiprocin

Psychoactive Class

Chemical Class

4-AcO-MiPT is a synthetic psychedelic of the tryptamine class.¹ It is the acetylated form of 4-HO-MiPT and a higher homolog of 4-AcO-DMT, commonly hypothesized to act primarily as a prodrug for its hydroxylated counterpart, though whether it possesses innate activity of its own remains debated. Very little is known about its human pharmacology or toxicity. It remains relatively uncommon, with minimal history of human use, and is primarily acquired through online research chemical vendors.

Dosage & Duration

Dosage

Threshold~5 mg

Light10-15 mg

Moderate15-20 mg

Strong20-35 mg

Heavy35+ mg

Duration

Onset15-45 minutes

Come Up60-120 minutes

Peak1.5-3 hours

Offset1-2 hours

After Effects2-4 hours

Total4-8 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

Runny nose Watery eyes

Cognitive

The cognitive effects of 4-AcO-MiPT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating.

Enhancement of current mind state Connectivity of thought Feelings of fascination, importance and awe Time distortion Outrospection Déjà vu Removal of cultural filter Feelings of predeterminism Conceptual thinking Direct communication with the subconscious Ego suppression, loss and death Feelings of interdependent opposites Delusions States of unity and interconnectedness

Visual

Distortions

Tracers After images Texture repetition Colour shifting Scenery slicing

Enhancements

Increased visual acuity Enhancement of colour Enhanced pattern recognition

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, unimmersive in depth and consistent in intensity. The visuals have a very 'natural' feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory States

4-AcO-MiPT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.

Transformations

Auditory

The auditory effects of 4-AcO-MiPT are common in their occurrence and exhibit a full range of effects.

Enhancements Distortions Hallucinations

Adapted from the 4-HO-MiPT subjective effects documentation. 4-AcO-MiPT is the acetylated prodrug of 4-HO-MiPT and is reported to produce an effectively identical experience. Forked from Subjective Effect Documentation

by Josie KinsJuly 2014.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)

Ehrlich(EH)

Hofmann(HM)

Morr(MO)

PROtestkit.eu

Pharmacology

Pharmacodynamics

4-AcO-MiPT has demonstrated direct activity at human 5-HT2 receptors in vitro. In calcium-mobilization assays it acted as a high-efficacy 5-HT2A agonist (EC50 43.9 nM; Emax 93.2%), a partial 5-HT2B agonist (EC50 44.7 nM; Emax 49.1%), and a lower-potency partial 5-HT2C agonist (EC50 542 nM; Emax 33.7%). These are functional potency and efficacy values, not binding affinities.²

In mice, 4-AcO-MiPT induced the 5-HT2A-associated head-twitch response with an ED50 of 1.11 mg/kg (2.84 µmol/kg). Its similar molar head-twitch potency to 4-HO-MiPT, despite being less potent in vitro at 5-HT2A, was interpreted by the study authors as consistent with in-vivo deacetylation; the study did not directly measure conversion of 4-AcO-MiPT to 4-HO-MiPT.²

Pharmacokinetics

The available compound-specific study supports a prodrug hypothesis indirectly: acetylation reduced in-vitro 5-HT2A potency, whereas 4-AcO-MiPT and 4-HO-MiPT had similar molar potency in the mouse head-twitch assay. Direct formation of 4-HO-MiPT was not measured, and human bioavailability, metabolic enzymes, plasma kinetics, and elimination half-life remain uncharacterized by this study.²

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Lithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Tramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

AmphetaminesCannabisCocaineDiphenhydramine

TripSit

Tolerance

Full Tolerance

Develops almost immediately after ingestion.

Baseline Reset

7 days

Half Tolerance

Approximately 3 days

Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Not considered habit-forming; the desire to use typically decreases rather than increases with repeated consumption. Like most classical psychedelics, it demonstrates self-regulating properties.³⁴

History & Culture

4-AcO-MiPT is a synthetic psychedelic tryptamine² that remains relatively obscure within the broader landscape of psychoactive substances. Unlike many classical psychedelics with decades of documented use, this compound has accumulated very little history of human…

Trip Reports

Legality

International

4-AcO-MiPT is not listed in the inspected current schedules of the 1971 Convention on Psychotropic Substances; its status under the 1961 and 1988 conventions remains a research gap.

By Country

United StatesNot scheduledFederal analogue rule

Controlled Substances Act; 21 U.S.C. § 813¹⁷¹⁸

Not specifically scheduled under the Controlled Substances Act.¹⁹ However, it may be considered an analogue of psilocin (4-HO-DMT), a Schedule I substance. Sale for human consumption or possession with intent to ingest could potentially be prosecuted under the Federal Analogue Act, though no such prosecutions have been documented.

GermanyIllegal (analog/blanket ban)NpSG Anlage 1

Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1⁶⁷⁸

Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since July 18, 2019.⁹ Production, import with intent to market, administration to others, and trading are criminal offenses.¹⁰ Possession is prohibited but not subject to criminal penalties.¹¹ Ordering may be considered incitement to place on the market.

NorwayIllegal4-AcO-MiPT

Forskrift om narkotika (narkotikaforskriften), Narkotikalisten¹³

Norway's Narkotikalisten expressly lists 4-AcO-MiPT and identifies it as 4-acetoksy-N-metyl-N-isopropyltryptamin. The substance is listed directly in the national narcotics regulation, rather than being recorded here through analogue coverage.

SwitzerlandPotentially Illegal

May be considered illegal under Buchstabe B of Swiss drug legislation as an ester analogue of 4-HO-MiPT, which is a controlled substance. Legal status depends on analogue interpretation.

FinlandIllegal

Banned in December 2014 as part of a government regulation prohibiting over 100 psychoactive substances with no accepted medical use.

JapanControlled SubstanceCitation needed

Designated as a controlled substance effective March 25, 2015 under Japanese drug control legislation.¹²

SwedenIllegalHealth-hazard list

Lag (1999:42) om förbud mot vissa hälsofarliga varor; Förordning (1999:58) om förbud mot vissa hälsofarliga varor¹⁴¹⁵

4-AcO-MIPT är uttryckligen upptaget som hälsofarlig vara i bilagan till förordning (1999:58). Lagen (1999:42) förbjuder utan tillstånd bland annat införsel, överlåtelse, framställning, försäljningsutbud och innehav; uppsåtliga överträdelser av de angivna förbuden är straffbelagda.

United KingdomClass ACitation needed

Controlled as a Class A substance because it is an ester of 4-HO-MiPT, which falls under the tryptamine catch-all clause of the Misuse of Drugs Act 1971.¹⁶ Class A carries the most severe penalties under UK law.

References

Source Pages

Citations

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4-AcO-MiPT

4-Acetoxy-N-methyl-N-isopropyltryptamine

Mipracetin, O-Acetylmiprocin

Psychoactive Class

Psychedelic

Chemical Class

Tryptamine