4-AcO-DET

4-Acetoxy-N,N-diethyltryptamine

Ethacetin, Ethylacybin, 4-Acetoxy-DET

Psychoactive Class

Chemical Class

4-AcO-DET is a synthetic psychedelic of the tryptamine class¹, first synthesized by Albert Hofmann at the Sandoz laboratory in 1958. It is chemically related to psilocin and belongs to a series of substituted tryptamines that includes 4-AcO-MET and 4-AcO-DMT. Its effects are generally compared to those of psilocybin mushrooms.² It remains a lesser-known research chemical, typically encountered as a slightly off-white powder and most commonly administered orally.

Dosage & Duration

Dosage

Threshold2-5 mg

Light5-15 mg

Moderate15-20 mg

Strong20-35 mg

Heavy35+ mg

Duration

Onset20-60 minutes

Come Up1-1.5 hours

Peak1.5-3 hours

Offset1-2 hours

After Effects2-4 hours

Total4-7 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Adapted from the 4-HO-DET subjective effects documentation. 4-AcO-DET is the acetylated prodrug of 4-HO-DET and is reported to produce an effectively identical experience. Forked from Subjective Effect Documentation work

by Josie KinsAugust 2016.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

4-AcO-DET is hypothesized to act principally as a prodrug for 4-HO-DET, its deacetylated counterpart³, though there is ongoing discussion as to whether the acetylated compound may also display intrinsic activity of its own.³ The psychedelic effects are thought to stem primarily from 5-HT2A receptor partial agonism.⁴ Very little data exists on the human pharmacology of 4-AcO-DET.

Pharmacokinetics

4-AcO-DET is expected to be rapidly hydrolyzed into the free phenolic 4-HO-DET by serum esterases³, though human studies confirming the metabolic fate of this compound are lacking.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Lithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Tramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

AmphetaminesCannabisCocaineDiphenhydramine

TripSit

Tolerance

Full Tolerance

4-AcO-DET can produce tolerance very soon after it is taken.¹

Baseline Reset

Approximately 7 days

Half Tolerance

Approximately 3 days

Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

4-AcO-DET is believed to be not habit-forming¹⁵, and the desire to use it may actually decrease with repeated use.

Psychosis Risk

Delusions are listed as a potential cognitive effect during intoxication, but no systematic data exists on intrinsic psychosis risk.

Seizure Risk

No intrinsic seizure risk has been documented for this substance.

History & Culture

4-AcO-DET was first synthesized in 1958 by Albert Hofmann at the Sandoz laboratories in Switzerland. Despite this early synthesis, the compound remained largely unexplored for decades and has accumulated very little documented history of human usage.²…

Trip Reports

Legality

By Country

United StatesUnscheduled

Not federally scheduled under the Controlled Substances Act. However, as a structural analogue of psilocin (4-HO-DMT), which is a Schedule I substance¹⁵, sale for human consumption or use for illicit purposes could potentially be prosecuted under the Federal Analogue Act.¹⁶

JapanControlled

Designated as a controlled substance⁸⁹ effective July 29, 2015, under national drug control legislation.

SwitzerlandControlled (Verzeichnis E)

Specifically named as a controlled substance under Verzeichnis E since November 1, 2005, pursuant to the Act on the Prohibition of Certain Goods Dangerous to Health.

United KingdomClass A

Controlled as a Class A substance due to its status as an ester of 4-HO-DET, which falls under the tryptamine catch-all clause of the Misuse of Drugs Act 1971.¹⁴ Carries the most severe penalties for possession, production, and supply.

GermanyAnlage I BtMG

Controlled under Anlage I of the Betäubungsmittelgesetz (Narcotics Act) since January 24, 1974, as it is classified as an ester of DET.⁶ Manufacturing, possession, importation, exportation, purchase, sale, and distribution are prohibited without a license.⁷

SwedenControlled

Classified as a health hazard under Lagen om förbud mot vissa hälsofarliga varor (Act on the Prohibition of Certain Goods Dangerous to Health) effective November 1, 2005, under regulation SFS 2005:733.¹⁰ Possession and sale are illegal.¹¹

TurkeyIllegal

Classified as a controlled drug.¹²¹³ Possession, production, supply, and importation are prohibited under Turkish drug law.

References

Source Pages

Citations

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4-AcO-DET

4-Acetoxy-N,N-diethyltryptamine

Ethacetin, Ethylacybin, 4-Acetoxy-DET

Psychoactive Class

Psychedelic

Chemical Class

Tryptamine