WARNINGREDOSING CAN TRIGGER PSYCHOSIS
PCP-like dissociatives can cause mania, paranoia, or psychosis that outlasts the high. High doses, redosing, and sleep loss raise the risk.
3-MeO-PCE
3-MeO-PCE is a dissociative hallucinogen of the arylcyclohexylamine classcitation needed and a structural analog of PCE.1 It began gaining popularity around 2010 as a grey-market research chemical, typically sold online as a legal alternative to PCP and ketamine.citation needed Its effects are reported to be qualitatively similar to those of PCE and PCP. It is considered potentially habit-forming, and its safety profile remains poorly characterized.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
At higher doses, the risk of adverse psychological effects increases significantly, including the potential for psychotic episodes, manic states, and delirium.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Reported as a dissociative anesthetic with a qualitative character comparable to PCE and PCP.
Physical
Cognitive
Visual
See also: Dissociative Intensity Scale, Subjective Effects of Dissociatives
Pharmacology
Pharmacodynamics
3-MeO-PCE acts primarily as an NMDA receptor antagonist, binding at the PCP site with high affinity (Ki 61 nM).citation needed It also displays significant affinity for the serotonin transporter and sigma-2 receptor,1 with additional binding at the dopamine transporter, alpha-2A adrenergic receptor, histamine H2 receptor, and sigma-1 receptor.
Pharmacokinetics
There have been no studies on the pharmacokinetic profile of 3-MeO-PCE and the metabolism of 3-MeO-PCE is unknown.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Dissociatives
Harm Potential
Addiction & Dependence
Psychological
High3-MeO-PCE is considered highly addictive with a high potential for adverse side effects. It has been reported to be more habit-forming than other dissociatives such as ketamine, MXE, diphenidine, and ephenidine. Compulsive redosing is commonly reported, particularly when smoked or vaporized due to the abrupt onset and offset via this route. Multiple reports describe users becoming seriously addicted daily users.
Physical
LowCravings and withdrawal effects may occur upon sudden cessation after addiction has developed, though the specific nature and severity of withdrawal symptoms are not well documented.
Toxicity
Chronic heavy use may cause bladder and urinary tract problems similar to those seen with ketamine, including urinary frequency, urgency, pressure, pelvic and bladder pain, hematuria, and incontinence; however, these effects appear less severe than with ketamine due to the higher potency of 3-MeO-PCE requiring significantly smaller quantities to achieve effects.
Psychosis Risk
3-MeO-PCE has been reported to cause psychosis, delusions, and mania at a significantly higher rate than other dissociatives such as ketamine, MXE, or diphenidine. Heavy doses and repeated use substantially increase this risk. These effects typically occur during the offset of the experience but can also manifest during onset or come up. Numerous experience reports describe states of psychotic delirium, amnesia, mania, and other serious consequences following abuse of this substance.
Seizure Risk
Seizures have been reported as a potential effect, though frequency, severity, and precipitating conditions are not well documented.
History & Culture
3-MeO-PCE emerged on the online research chemical market around 2010,citation needed where it was marketed as a grey-area legal alternative to controlled dissociatives such as PCP and ketamine. The compound represents part of the broader wave of designer arylcyclohexylamines that became available…
Trip Reports
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Legality
International
3-MeO-PCE is not listed under the 1961 Single Convention on Narcotic Drugs. It is not listed under the 1971 Convention on Psychotropic Substances. It is not listed under the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
By Country
References
Source Pages
Citations
- Bryan L. Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, & Les Iversen. (March 2013). The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. PLOS ONE, 8(3). https://doi.org/10.1371/journal.pone.005933412
- Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine report, 2012. UK Home Office (18 October 2012). https://www.gov.uk/government/publications/advisory-council-on-the-misuse-of-drugs-acmd-methoxetamine-report-20121
- Neue-Psychoaktive-Substanzen-Verordnung (NPSV), BGBl. II Nr. 468/2011, as amended by BGBl. II Nr. 106/2024. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=200076421
- Neue-Psychoaktive-Substanzen-Verordnung (NPSV), BGBl. II Nr. 468/2011, as amended by BGBl. II Nr. 106/2024. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
- Neue-Psychoaktive-Substanzen-Verordnung (NPSV), BGBl. II Nr. 468/2011, as amended by BGBl. II Nr. 106/2024. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=200076051
- PubChem compound record: N-Ethyl-1-(3-methoxyphenyl)cyclohexanamine, CID 57461569. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/compound/574615691
- PubChem PUG-REST identity properties for CID 57461569. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57461569/property/Title,IUPACName,MolecularFormula,MolecularWeight,CanonicalSMILES,InChI,InChIKey/JSON1
- PubChem PUG-REST synonyms for CID 57461569. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57461569/synonyms/JSON12
- PubChem PUG-REST identity properties for parent eticyclidine/PCE. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/Eticyclidine/property/Title,IUPACName,MolecularFormula,CanonicalSMILES/JSON1
- Reglamento de la Ley N° 20.000, TM-014 A, Armada de Chile Directemar compilation. directemar.cl (n.d.). https://www.directemar.cl/directemar/site/docs/20170126/20170126122722/tm_014_a_actualizado_al_16_septiembre_2023.pdf1
Further Reading
Article Status
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Recent changes8 human edits · latest
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27 August 2026
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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