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WARNINGREDOSING CAN TRIGGER PSYCHOSIS
PCP-like dissociatives can cause mania, paranoia, or psychosis that outlasts the high. High doses, redosing, and sleep loss raise the risk.
3-HO-PCP
3-Hydroxyphencyclidine
3-OH-PCP, Hydroxyphencyclidine
3-HO-PCP is a synthetic dissociative of the arylcyclohexylamine class and a structural analogue of phencyclidine (PCP). First synthesized in 1978 to explore the structure-activity relationships of PCP derivatives,citation needed it has since emerged as a designer drug. It is known for producing potent dissociative, hallucinogenic, and euphoric effects. Notably, beyond its primary activity as an NMDA receptor antagonist, it possesses appreciable affinity for the μ-opioid receptor.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~1 mg
Light1-2 mg
Moderate3-5 mg
Strong5-8 mg
Heavy8+ mg
Repeated doses can produce cumulative effects that may reach dangerous levels.
Duration
Onset20-40 minutes
Come Up60-90 minutes
After Effects2 hours
Total5-7 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
3-HO-PCP produces a dissociative experience with an unusually pronounced opioid-like character, reflecting its high affinity for both the NMDA and μ-opioid receptors, a combination unique among the arylcyclohexylamines. Onset is slow, commonly taking up to two hours to fully develop, beginning with a subtly distant headspace and tingling numbness before settling into a warm, contented state of mild dissociation. The experience carries a distinctive heady presence and an undercurrent of fatigue, and it resolves into a gentle afterglow with a dreamy, content disposition and a sense of mental reset typical of dissociatives.
Physical
The body feel combines warmth and flushing with numbness in the hands and fingers, alongside opioid-like comfort and analgesia. A wearing sense of fatigue accompanies the trip, temperature perception can swing from warm to chilly, and a mild lingering headache may follow the experience.
Bodily
Temperature
Cognitive
The headspace is distant but lucid at moderate doses, with users remaining in full control of their faculties. The emotional tone is rounded and contented in a manner reminiscent of opioids, time passes noticeably faster than usual, and the tail end of the experience takes on a dreamy quality.
Emotional
Tactile
A tingly numbness develops early in the hands and persists in the fingers through the offset of the experience.
Multisensory
Sensory input as a whole takes on a subtly altered, removed quality without overt distortion at lighter doses.
See also: Dissociative Intensity Scale, Subjective Effects of Dissociatives
Pharmacology
Pharmacodynamics
3-HO-PCP acts primarily as a high-affinity uncompetitive antagonist of the NMDA receptor at the dizocilpine (MK-801) site.citation needed The substance also displays appreciable affinity for the μ-opioid receptor, the σ1 receptor, and the κ-opioid receptor, with only low affinity for the δ-opioid receptor. μ-Opioid receptor agonist activity has been observed in animal models, though whether this property extends to humans remains unknown.
Pharmacokinetics
Very little is known about the metabolism of 3-HO-PCP in humans.citation needed 3-HO-PCP is itself a known metabolite of 3-MeO-PCP.
Metabolitesnone documented yet
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
DepressantsStimulants
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Full Tolerance
Many effects are believed to become less responsive after sustained repeated use, requiring higher doses for similar results.
Baseline Reset
1-2 weeks
Half Tolerance
4-7 days
Cross Tolerance
Dissociatives
Harm Potential
Addiction & Dependence
Psychological
ModerateEarly reports suggest 3-HO-PCP is likely to be moderately addictive with notable habit-forming properties. It appears to be more habit-forming than dissociatives such as MXE, ketamine, and DCK. Compulsive redosing is reported, particularly prominent when smoked or vaporized due to the abrupt onset and offset of effects.
Physical
LowWhen addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops usage. The severity and nature of withdrawal symptoms are not well documented.
Toxicity
Urinary System
Repeated and excessive use over extended periods is likely to cause bladder and urinary tract problems similar to those seen with ketamine, though potentially to a lesser extent because 3-HO-PCP's higher potency means less material needs to be consumed.
Cardiovascular
Acute cardiovascular effects including abnormal heartbeat, increased blood pressure, and increased heart rate occur during intoxication.
Respiratory
Respiratory depression may occur, particularly at higher doses or when combined with other depressants.citation needed
General
Reports indicate that this compound may cause more pronounced physical reactions during or shortly after use, including aching muscles and flu-like symptoms, and that higher doses may be unusually dangerous or toxic compared with related dissociatives.
Psychosis Risk
There is a notable risk of psychosis, delusions, and mania, particularly with chronic use, high doses, or compulsive redosing before fully sober. As an analogue of PCP, which reportedly causes higher rates of mania and psychosis than other dissociatives, similar concerns apply. Avoiding consecutive daily use and staying within recommended dosage ranges is advised to reduce this risk.
Seizure Risk
Seizures are likely possible in people who are already susceptible to them, particularly under physically stressful conditions such as dehydration, exhaustion, or inadequate nutrition. How readily this effect can occur has not been well established.
History & Culture
3-HO-PCP was first synthesized in 1978 during investigations into the structure-activity relationships of phencyclidine (PCP) derivatives.citation needed Throughout the 1980s, researchers continued to characterize its pharmacological properties, discovering its activity at opioid receptors in…
Trip Reports
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Legality
By Country
Illegal5
Czech RepublicSchedule I (List 4)Controlled under Nařízení vlády č. 463/2013 Sb. (§ 1, d), 1.). Permitted for research purposes and restricted therapeutic applications only.1
GermanyIllegalNeue-psychoaktive-Stoffe-Gesetz (NpSG), § 2 Nr. 1 Buchstabe a and § 3 Abs. 1 Nr. 1 with Abs. 2; Anlage 1 Nr. 6 (current consolidated text, last amended 7 January 2026)2345
The current German NpSG uses generic substance-group coverage: 3-HO-PCP's 3-hydroxyaryl/1-piperidinylcyclohexyl structure falls within Anlage 1 Nr. 6's arylcyclohexyl(methyl)amine-derived group and 500 u maximum, subject to the group's structural conditions. NpSG § 3 Abs. 1 Nr. 1 prohibits trade, placing into circulation, manufacture, import/export/transit, acquisition, possession and administration, with the statutory § 3 Abs. 2 exceptions. The NpSG's general statutory exclusions (including BtMG narcotics and AMG medicinal products under § 1 Abs. 2) remain applicable where their factual conditions are met. 3-HO-PCP is not separately named.
SwedenIllegalProhibited substance under Swedish drug control legislation.6
SwitzerlandIllegal (analog/blanket ban)Swiss BetmVV-EDI Annex 6 Verzeichnis e item 2917
Verzeichnis e is the category for raw materials and products with presumed narcotic-like effects.
TurkeyIllegalLaw No. 2313 on the Control of Narcotic Drugs, Art. 19; Presidential Decision No. 1335 of 19 July 2019 (Official Gazette 20 July 2019, issue 30837), appendix; Turkish Penal Code (Law No. 5237), Arts. 188(1), 188(3), 188(6) and 191(1)-(5), in the Ministry of Justice consolidation uploaded 23 June 2025; Law No. 7445 amendments to Arts. 188(4)(a) and 191(2)-(3); official TBMM Law No. 7571 record (published 25 December 2025).8910111213
Decision No. 1335 directly names 3-HO-PCP. The ordinary rule is prohibition of unauthorized handling; Law No. 2313 Article 19 is the NPS-style mechanism that permits later named additions by Presidential decision. Articles 188(1) and 188(3) set out conduct-specific manufacture/import/export and domestic trafficking/possession penalties. Article 191 is the separate personal-use route, and classification between Article 188 and Article 191 depends on facts such as purpose and evidence. Article 188(6) does not grant a prescription pathway for 3-HO-PCP; no authorized medicinal product or prescription listing exists for it. The 2019 named listing was not displaced by the later Decision No. 2143 appendix or later law.
Controlled / restricted1
United KingdomClass BControlled under the Misuse of Drugs Act 1971 via the arylcyclohexylamine generic clause introduced by S.I. 2013/239, effective February 26, 2013. As a derivative of 1-phenylcyclohexylamine with a 1-piperidyl group and hydroxy substitution on the phenyl ring, it falls within this catch-all provision. Possession, production, supply, and importation are criminal offenses.14
References
Source Pages
Citations
- Nařízení vlády č. 463/2013 Sb. o seznamech návykových látek — § 1 písm. d) bod 2 (Příloha č. 4). Czech Republic Government (2013-12-18). https://krajta.slv.cz/2013/463/par_1-pism_d-bod_21
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 2 Nr. 1 Buchstabe a, current consolidated text. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__2.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 6, current consolidated text. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 3, current consolidated text. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), official consolidated text and amendment status. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/BJNR261510016.html1
- Förordning (1992:1554) om kontroll av narkotika — Bilaga 1. Riksdagsförvaltningen (n.d.). https://www.riksdagen.se/sv/dokument-och-lagar/dokument/svensk-forfattningssamling/forordning-19921554-om-kontroll-av-narkotika_sfs-1992-1554/1
- Swiss BetmVV-EDI, Annex 6 Verzeichnis e. fedlex.admin.ch (n.d.). https://www.fedlex.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20260313/de/pdf-a/fedlex-data-admin-ch-eli-cc-2011-363-20260313-de-pdf-a-3.pdf1
- NIH PubChem PUG REST, 3-HO-PCP identity properties (CID 133277). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/3-HO-PCP/property/Title,IUPACName,CanonicalSMILES,IsomericSMILES,MolecularFormula,MolecularWeight/JSON1
- Official Turkish legislation database, Law No. 2313 consolidated PDF, Article 19. mevzuat.gov.tr (n.d.). https://www.mevzuat.gov.tr/mevzuatmetin/1.3.2313.pdf1
- Official Gazette, 20 July 2019 issue 30837, Decision No. 1335 and appendix. resmigazete.gov.tr (n.d.). https://www.resmigazete.gov.tr/eskiler/2019/07/20190720-18.pdf1
Further Reading
Article Status
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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