yellow2 → orange2 → red2 → brown2 → yellow2
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2-MMC
2-Methylmethcathinone
Ortho, Orthomephedrone, Orthophedrone, 2-methyl MC
2-MMC is a substituted cathinone1 and designer drug with stimulant and entactogenic properties. First identified in Sweden in 2014, it is a positional isomer of the better-known 3-MMC and mephedrone (4-MMC).citation needed Despite its cathinone structure, its effects have been compared more closely to those of amphetamine and 2-FA, leaning toward functional stimulation. As a research chemical, limited data exists regarding its safety profile and long-term effects.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~5 mg
Light5-15 mg
Moderate15-40 mg
Strong40-80 mg
Heavy80+ mg
Duration
Onset5-10 minutes
Come Up10-20 minutes
Peak1-1.5 hours
Offset1-2 hours
After Effects2-4 hours
Total3-5 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
2-MMC is described as a stimulant with euphoric effects. Despite its chemical relationship to cathinones such as mephedrone and 3-MMC, its effects are characterized as resembling those of 2-FA or amphetamine more closely than other substituted cathinones.
Physical
The substance is documented as stimulating.
Cognitive
Euphoria is the primary reported mental effect.
Pharmacology
Pharmacodynamics
2-MMC acts as a releasing agent at the serotonin, norepinephrine, and dopamine transporters, with a higher preference for the norepinephrine and dopamine transporters relative to the serotonin transporter.2
Pharmacokinetics
There have been no studies on the pharmacokinetic profile of 2-MMC and the metabolism of 2-MMC is unknown.
Metabolitesnone documented yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance not written up yet
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming, suggesting potential for psychological dependence, though specific risk data is not available for this research chemical.
History & Culture
2-Methylmethcathinone emerged as a novel psychoactive substance during the mid-2010s wave of synthetic cathinone proliferation. The compound was first identified by Swedish authorities in 2014citation needed, representing one of the later positional isomers of mephedrone to appear on the…
Legality
By Country
Illegal14
AustraliaIllegal2-MMC is covered by the Poisons Standard's generic Schedule 9 entry, "CATHINONES except when separately specified in these Schedules." Schedule 9 describes prohibited substances whose manufacture, possession, supply and use should be prohibited except for approved medical or scientific research, analytical, teaching or training purposes. The Standard states that its scheduling classifications are implemented through State and Territory legislation.
AustriaIllegalSuchtgiftverordnung, Anhang IV.26
2-MMC is listed as 2-Methylmethcathinon in Anhang IV.2 of Austria's Suchtgiftverordnung. The annex treats substances in that part as equivalent to narcotic drugs because of a comparable danger potential.
BrazilIllegal (analog/blanket ban)2-MMC (2-methylmethcathinone/ortomephedrone) falls within Lista F2's controlled structural class of synthetic cathinones. The class covers a 2-aminopropan-1-one bearing a benzene ring that may carry an alkyl substituent at any position, with permitted N-alkyl substitution and a methyl at position 2; 2-MMC has the listed 2-methylphenyl and N-methyl features. Lista F2 is the list of psychotropic substances of prohibited use in Brazil.
DenmarkIllegal (analog/blanket ban)BEK nr. 405 af 26/03/2026, Bekendtgørelse om euforiserende stoffer, Bilag 1, liste B, nr. 453 (Cathinon-gruppen)9
2-MMC (2-methylmethcathinone) is covered by the List B Cathinon-gruppen because it is structurally derived from 2-amino-1-phenylpropan-1-one with an alkyl substituent on the benzene ring and a methyl substituent on the amino group. It is not one of the cathinone derivatives excluded from the group for separate listing; List B substances may only be used for medical and scientific purposes, subject to the regulation's controls.
IrelandIllegal (analog/blanket ban)2-MMC is covered by Schedule 1's generic cathinone definition: it is structurally derived from 2-amino-1-phenyl-1-propanone through methyl substitution in the phenyl ring and methyl substitution at the nitrogen atom. The 2022 Designation Order designates the same Schedule 1 drugs for section 13(1) of the Misuse of Drugs Act 1977; manufacture, production, preparation, sale, supply, distribution and possession are unlawful except for the stated research or special purposes. The 2025 amendment adds listed substances to Schedule 1 but does not alter this generic definition.
ItalyIllegalMinistero della Salute, decreto 16 dicembre 2025 (25A06899), Tabella I del DPR 9 ottobre 1990, n. 30917
2-MMC (2-Metilmetcatinone) is listed in Tabella I of Italy's controlled-substances tables. The decree records that it was already controlled through the Table I structural-analogue category and adds its specific names for ready identification. It is published on 29 December 2025 and enters into force on 13 January 2026, the fifteenth day after publication.
NetherlandsIllegal (analog/blanket ban)Opiumwet, List IA, substance group 118
2-MMC is covered by the Opiumwet's List IA substance group for substances derived from 2-phenethylamine. The definition expressly includes substances with the basic structure of cathinone and beta-keto derivatives; import, manufacture, sale, supply, transport, and possession of a substance in the group are prohibited.
NorwayIllegalForskrift om narkotika (narkotikaforskriften)19
2-MMC is listed in Norway's narcotics list as 2-metylmetkatinon. The narcotics regulation prohibits the substances listed under section 5.
PolandIllegalRozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz.U. 2024 poz. 1139, ze zm.)202122
2-MMC (2-metylometkatynon) is identified by the Chief Sanitary Inspectorate as a cathinone derivative in group II-NPS and is controlled under the Minister of Health regulation's general formula and/or note. The GIS list says it will be transferred to psychotropic-substance group II-P under the European Commission delegated directive of 14 October 2025; this is stated as a future transfer, not its present classification. The current official classification is therefore II-NPS, not II-P or I-P.
PortugalIllegalPortaria n.º 154/2013, as republished and amended by Portaria n.º 232/2022, under Decreto-Lei n.º 54/201323
2-Metilmetcatinona is item 41 under "Derivados da Catinona" in the list of new psychoactive substances republished by Portaria n.º 232/2022. Under Decreto-Lei n.º 54/2013, the listed substance is subject to a prohibition on production, import, export, advertising, distribution, sale, possession, and making available.
SingaporeIllegal (analog/blanket ban)Misuse of Drugs Act 1973, First Schedule24
Singapore's First Schedule controls compounds structurally derived from 2-amino-1-phenylpropan-1-one when the phenyl ring is substituted with an alkyl group and the 2-amino nitrogen is substituted with an alkyl group. 2-MMC, 1-(2-methylphenyl)-2-(methylamino)propan-1-one, matches those substitutions: an ortho-methyl phenyl group and an N-methyl group. The Schedule therefore covers 2-MMC as a Class A controlled drug even though it does not list the exact name separately.
SwedenIllegal1-(2-metylfenyl)-2-(metylamino)propan-1-on is expressly listed as 2-MMC (2-metylmetkatinon) among the central stimulants in Bilaga 1 to Förordning (1992:1554) om kontroll av narkotika. Section 2 provides that the substances in that annex are to be regarded as narcotics under Narkotikastrafflag (1968:64), so 2-MMC is nationally controlled as a narcotic rather than only covered by an analogue or NPS rule.
Controlled / restricted2
GermanyRestricted2-Methylmethcathinon (2-MMC, Ortomephedron) is expressly listed in Anlage II BtMG. The listed substance is a Betäubungsmittel; its cultivation, manufacture, trade, import, export, supply, sale, other placing on the market, and acquisition require a Bundesinstitut für Arzneimittel und Medizinprodukte permit. Anlage II substances may not be prescribed, administered, or supplied for immediate consumption. Unauthorized listed dealings and possession without written acquisition permission are punishable under § 29 BtMG.
SpainRestrictedOrden SND/362/2026, de 13 de abril, por la que se modifica el anexo 1 del Real Decreto 2829/1977, de 6 de octubre; Real Decreto 2829/1977, de 6 de octubre (texto consolidado)2526
Added to List II of annex 1 effective 22 April 2026. The current consolidated Real Decreto text subjects List II substances to authorization, recordkeeping, import/export authorization, and prescription/dispensing controls; the decree's prohibition provision applies to List I, not List II.
References
Source Pages
Citations
- John D Power, Peggy McGlynn, Karen Clarke, Seán D McDermott, Pierce Kavanagh, & John O'Brien. (2011). The analysis of substituted cathinones. Part 1: chemical analysis of 2-, 3- and 4-methylmethcathinone. 212, 6-12. https://doi.org/10.1016/j.forsciint.2011.04.0201
- Donna Walther, Abdelrahman R Shalabi, Michael H Baumann, & Richard A Glennon. (January 2019). Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents. ACS Chem Neurosci, 10(1), 740–745. https://doi.org/10.1021/acschemneuro.8b005241
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F1996B03651/2026-03-26/2026-03-26/text/original/epub/OEBPS/document_1/document_1.html1
- Suchtgiftverordnung, Anhang IV.2. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=4&Artikel=&Gesetzesnummer=10011053&Paragraf=&Uebergangsrecht=1
- Portaria SVS/MS nº 344/1998, Anexo I, Lista F2(c), as updated by RDC ANVISA nº 1.021/2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=detalharAto&cod_menu=1696&cod_modulo=134&desItem=&desItemFim=&nomeTitulo=codigos&numeroAto=00001021&orgao=RDC%2FDC%2FANVISA%2FMS&pesquisa=true&seqAto=000&tipo=RDC&valorAno=20261
- Portaria SVS/MS nº 344/1998, Anexo I, Lista F2(c), as updated by RDC ANVISA nº 1.021/2026. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista-substancias1
- Bekendtgørelse om euforiserende stoffer (BEK nr. 405 af 26/03/2026). retsinformation.dk (n.d.). https://www.retsinformation.dk/api/pdf/2559321
- Betäubungsmittelgesetz (BtMG). gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html1
Further Reading
Brandt et al. 2020 - Pharmacological profiling of ortho-mephedrone (2-MMC)
Eshleman et al. 2013 - Substituted methcathinones differ in transporter and receptor interactions- Eshleman et al. 2013 – Substituted cathinones as monoamine transporter substrates
EUDA: Initial Report - 2-Methylmethcathinone (2-MMC)
NDEWS: Web Monitoring Alert - Online mentions of 2-MMC- Simmler et al. 2014 - Monoamine transporter and receptor interaction profiles of designer cathinones
User reports compilation – r/ResearchChemicals: “2-MMC turns me into a sex fiend” (Reddit, 2024)
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
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Recent changes8 human edits · latest
Times are UTCNewest first
29 August 2026
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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