2-MMC
2-MMC is a substituted cathinone1 and designer drug with stimulant and entactogenic properties. First identified in Sweden in 2014, it is a positional isomer of the better-known 3-MMC and mephedrone (4-MMC).12 Despite its cathinone structure, its effects have been compared more closely to those of amphetamine and 2-FA, leaning toward functional stimulation. As a research chemical, limited data exists regarding its safety profile and long-term effects.
Contents
Dosage & Duration
Dosage
Subjective Effects
2-MMC is described as a stimulant with euphoric effects. Despite its chemical relationship to cathinones such as mephedrone and 3-MMC, its effects are characterized as resembling those of 2-FA or amphetamine more closely than other substituted cathinones.
Physical
The substance is documented as stimulating.
Cognitive
Euphoria is the primary reported mental effect.
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
2-MMC acts as a releasing agent at the serotonin, norepinephrine, and dopamine transporters, with a higher preference for the norepinephrine and dopamine transporters relative to the serotonin transporter.3
Pharmacokinetics
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming, suggesting potential for psychological dependence, though specific risk data is not available for this research chemical.
History & Culture
2-Methylmethcathinone emerged as a novel psychoactive substance during the mid-2010s wave of synthetic cathinone proliferation. The compound was first identified by Swedish authorities in 20142, representing one of the later positional isomers of mephedrone to appear…
Legality
By Country
References
Source Pages
Citations
- (2011). The analysis of substituted cathinones. Part 1: chemical analysis of 2-, 3- and 4-methylmethcathinone. 212, 6-12. https://doi.org/10.1016/j.forsciint.2011.04.02012
- (2025). EUDA Initial Report on the New Psychoactive Substance 2-MMC (2-Methylmethcathinone). European Union Drugs Agency (EUDA). https://www.euda.europa.eu/system/files/documents/2025-07/initial-report-on-2-mmc.pdf1234
- (January 2019). Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents. ACS Chem Neurosci, 10(1), 740–745. https://doi.org/10.1021/acschemneuro.8b005241
- (n.d.). Neue-psychoaktive-Stoffe-Gesetz (NpSG) Anlage — Gruppe 1: Von 2-Phenethylamin abgeleitete Verbindungen. https://www.buzer.de/Anlage_NpSG.htm1
- (n.d.). Neue-psychoaktive-Stoffe-Gesetz § 4 Strafvorschriften. https://www.gesetze-im-internet.de/npsg/__4.html1
- (n.d.). Misuse of Drugs Act 1971 — Schedule 2, Part II, paragraph 1(aa) (cathinone derivatives). https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- (n.d.). Misuse of Drugs Act 1971 — Schedule 4, Part II (Class B penalties). https://www.legislation.gov.uk/ukpga/1971/38/schedule/41
- (n.d.). 21 CFR § 1308.11(d) — Schedule I Hallucinogenic Substances (including mephedrone and isomer definition). https://www.law.cornell.edu/cfr/text/21/1308.1112
Further Reading
Brandt et al. 2020 - Pharmacological profiling of ortho-mephedrone (2-MMC)
Eshleman et al. 2013 - Substituted methcathinones differ in transporter and receptor interactions- Eshleman et al. 2013 – Substituted cathinones as monoamine transporter substrates
EUDA: Initial Report - 2-Methylmethcathinone (2-MMC)
NDEWS: Web Monitoring Alert - Online mentions of 2-MMC- Simmler et al. 2014 - Monoamine transporter and receptor interaction profiles of designer cathinones
User reports compilation – r/ResearchChemicals: “2-MMC turns me into a sex fiend” (Reddit, 2024)
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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