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2-MMC

2-Methylmethcathinone

Ortho, Orthomephedrone, Orthophedrone, 2-methyl MC

Psychoactive Class

Stimulant Entactogen

Chemical Class

Cathinone (substituted)

2-MMC is a substituted cathinone¹ and designer drug with stimulant and entactogenic properties. First identified in Sweden in 2014, it is a positional isomer of the better-known 3-MMC and mephedrone (4-MMC).¹² Despite its cathinone structure, its effects have been compared more closely to those of amphetamine and 2-FA, leaning toward functional stimulation. As a research chemical, limited data exists regarding its safety profile and long-term effects.

Dosage & Duration

Dosage

Threshold~5 mg

Light5-15 mg

Moderate15-40 mg

Strong40-80 mg

Heavy80+ mg

Subjective Effects

2-MMC is described as a stimulant with euphoric effects. Despite its chemical relationship to cathinones such as mephedrone and 3-MMC, its effects are characterized as resembling those of 2-FA or amphetamine more closely than other substituted cathinones.

Physical

The substance is documented as stimulating.

Stimulation

Cognitive

Euphoria is the primary reported mental effect.

Euphoria

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mandelin(MD)

Liebermann(LB)

Morr(MO)

Simons(SI)

PROtestkit.eu

Pharmacology

Pharmacodynamics

2-MMC acts as a releasing agent at the serotonin, norepinephrine, and dopamine transporters, with a higher preference for the norepinephrine and dopamine transporters relative to the serotonin transporter.³

Pharmacokinetics

There have been no studies on the pharmacokinetic profile of 2-MMC and the metabolism of 2-MMC is unknown.

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check

TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Classified as habit-forming, suggesting potential for psychological dependence, though specific risk data is not available for this research chemical.

History & Culture

2-Methylmethcathinone emerged as a novel psychoactive substance during the mid-2010s wave of synthetic cathinone proliferation. The compound was first identified by Swedish authorities in 2014², representing one of the later positional isomers of mephedrone to appear…

Legality

By Country

United StatesIllegalSchedule I

Controlled Substances Act³⁴³⁵³⁶

Controlled under the Controlled Substances Act as a hallucinogenic substance.³⁷ Regulated as a positional isomer of mephedrone (4-MMC), which places it automatically under Schedule I classification.³⁷

AustriaIllegalAnhang IV.2

Suchtgiftverordnung, Anhang IV.2⁷

2-MMC is listed as 2-Methylmethcathinon in Anhang IV.2 of Austria's Suchtgiftverordnung. The annex treats substances in that part as equivalent to narcotic drugs because of a comparable danger potential.

DenmarkIllegal (analog/blanket ban)Cathinon-gruppen

BEK nr. 405 af 26/03/2026, Bekendtgørelse om euforiserende stoffer, Bilag 1, liste B, nr. 453 (Cathinon-gruppen)¹⁰

2-MMC (2-methylmethcathinone) is covered by the List B Cathinon-gruppen because it is structurally derived from 2-amino-1-phenylpropan-1-one with an alkyl substituent on the benzene ring and a methyl substituent on the amino group. It is not one of the cathinone derivatives excluded from the group for separate listing; List B substances may only be used for medical and scientific purposes, subject to the regulation's controls.

IrelandIllegal (analog/blanket ban)Schedule 1 analogue

Schedule 1, Misuse of Drugs Regulations 2017 (as substituted by S.I. No. 210/2022)¹⁵¹⁶¹⁷

2-MMC is covered by Schedule 1's generic cathinone definition: it is structurally derived from 2-amino-1-phenyl-1-propanone through methyl substitution in the phenyl ring and methyl substitution at the nitrogen atom. The 2022 Designation Order designates the same Schedule 1 drugs for section 13(1) of the Misuse of Drugs Act 1977; manufacture, production, preparation, sale, supply, distribution and possession are unlawful except for the stated research or special purposes. The 2025 amendment adds listed substances to Schedule 1 but does not alter this generic definition.

NetherlandsIllegal (analog/blanket ban)Lijst IA

Opiumwet, List IA, substance group 1¹⁹

2-MMC is covered by the Opiumwet's List IA substance group for substances derived from 2-phenethylamine. The definition expressly includes substances with the basic structure of cathinone and beta-keto derivatives; import, manufacture, sale, supply, transport, and possession of a substance in the group are prohibited.

PolandIllegalII-NPS

Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz.U. 2024 poz. 1139, ze zm.)²¹²²²³

2-MMC (2-metylometkatynon) is identified by the Chief Sanitary Inspectorate as a cathinone derivative in group II-NPS and is controlled under the Minister of Health regulation's general formula and/or note. The GIS list says it will be transferred to psychotropic-substance group II-P under the European Commission delegated directive of 14 October 2025; this is stated as a future transfer, not its present classification. The current official classification is therefore II-NPS, not II-P or I-P.

SingaporeIllegal (analog/blanket ban)Class A drug

Misuse of Drugs Act 1973, First Schedule²⁵

Singapore's First Schedule controls compounds structurally derived from 2-amino-1-phenylpropan-1-one when the phenyl ring is substituted with an alkyl group and the 2-amino nitrogen is substituted with an alkyl group. 2-MMC, 1-(2-methylphenyl)-2-(methylamino)propan-1-one, matches those substitutions: an ortho-methyl phenyl group and an N-methyl group. The Schedule therefore covers 2-MMC as a Class A controlled drug even though it does not list the exact name separately.

SwedenIllegalNarkotika

Bilaga 1, Förordning (1992:1554) om kontroll av narkotika; Narkotikastrafflag (1968:64)²⁸²⁹

1-(2-metylfenyl)-2-(metylamino)propan-1-on is expressly listed as 2-MMC (2-metylmetkatinon) among the central stimulants in Bilaga 1 to Förordning (1992:1554) om kontroll av narkotika. Section 2 provides that the substances in that annex are to be regarded as narcotics under Narkotikastrafflag (1968:64), so 2-MMC is nationally controlled as a narcotic rather than only covered by an analogue or NPS rule.

AustraliaIllegalSchedule 9 cathinones

Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026⁴⁵⁶

2-MMC is covered by the Poisons Standard's generic Schedule 9 entry, "CATHINONES except when separately specified in these Schedules." Schedule 9 describes prohibited substances whose manufacture, possession, supply and use should be prohibited except for approved medical or scientific research, analytical, teaching or training purposes. The Standard states that its scheduling classifications are implemented through State and Territory legislation; Criminal Code and customs border controls do not establish domestic status.

BrazilIllegal (analog/blanket ban)F2 synthetic cathinone

Portaria SVS/MS nº 344/1998, Anexo I, Lista F2(c), as updated by RDC ANVISA nº 1.021/2026⁸⁹

2-MMC (2-methylmethcathinone/ortomephedrone) falls within Lista F2's controlled structural class of synthetic cathinones. The class covers a 2-aminopropan-1-one bearing a benzene ring that may carry an alkyl substituent at any position, with permitted N-alkyl substitution and a methyl at position 2; 2-MMC has the listed 2-methylphenyl and N-methyl features. Lista F2 is the list of psychotropic substances of prohibited use in Brazil.

GermanyRestrictedAnlage II

Betäubungsmittelgesetz (BtMG)^11121314

2-Methylmethcathinon (2-MMC, Ortomephedron) is expressly listed in Anlage II BtMG. The listed substance is a Betäubungsmittel; its cultivation, manufacture, trade, import, export, supply, sale, other placing on the market, and acquisition require a Bundesinstitut für Arzneimittel und Medizinprodukte permit. Anlage II substances may not be prescribed, administered, or supplied for immediate consumption. Unauthorized listed dealings and possession without written acquisition permission are punishable under § 29 BtMG.

ItalyIllegalTabella I

Ministero della Salute, decreto 16 dicembre 2025 (25A06899), Tabella I del DPR 9 ottobre 1990, n. 309¹⁸

2-MMC (2-Metilmetcatinone) is listed in Tabella I of Italy's controlled-substances tables. The decree records that it was already controlled through the Table I structural-analogue category and adds its specific names for ready identification. It is published on 29 December 2025 and enters into force on 13 January 2026, the fifteenth day after publication.

NorwayIllegalNarkotikalisten

Forskrift om narkotika (narkotikaforskriften)²⁰

2-MMC is listed in Norway's narcotics list as 2-metylmetkatinon. The narcotics regulation prohibits the substances listed under section 5.

PortugalIllegal2-Metilmetcatinona

Portaria n.º 154/2013, as republished and amended by Portaria n.º 232/2022, under Decreto-Lei n.º 54/2013²⁴

2-Metilmetcatinona is item 41 under "Derivados da Catinona" in the list of new psychoactive substances republished by Portaria n.º 232/2022. Under Decreto-Lei n.º 54/2013, the listed substance is subject to a prohibition on production, import, export, advertising, distribution, sale, possession, and making available.

SpainRestrictedLista II · Ítem 79

Orden SND/362/2026, de 13 de abril, por la que se modifica el anexo 1 del Real Decreto 2829/1977, de 6 de octubre; Real Decreto 2829/1977, de 6 de octubre (texto consolidado)²⁶²⁷

Added to List II of annex 1 effective 22 April 2026. The current consolidated Real Decreto text subjects List II substances to authorization, recordkeeping, import/export authorization, and prescription/dispensing controls; the decree's prohibition provision applies to List I, not List II.

United KingdomIllegalClass B

Misuse of Drugs Act 1971³⁰³¹³²

Controlled under the Misuse of Drugs Act 1971.³⁰ Class B substances carry penalties of up to 5 years imprisonment for possession and up to 14 years for supply or production.³³

References

Source Pages

Citations

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