2-FEA
2-FEA is a novel synthetic stimulant of the substituted amphetamine class. It is the N-ethylated homolog of 2-fluoroamphetamine (2-FA), featuring an ethyl group bound to the terminal amine of the amphetamine backbone.citation needed 2-FEA produces classical stimulant and entactogenic effects, including stimulation, enhanced focus, and euphoria. It has limited documented history of human use and is primarily available through the online research chemical market.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
The subjective effects of 2-FEA are very poorly documented, with little formal or anecdotal characterization available. What limited reporting exists describes it as a mild stimulant of the substituted amphetamine family, producing wakefulness and modest physical energy rather than a strongly recreational or perceptually altering experience.
Physical
Mild stimulation and increased wakefulness are the primary reported physical effects.
Stimulation
Pharmacology
Pharmacodynamics
In an in-vitro human monoamine-transporter uptake assay, 2-FEA inhibited DAT and NET at similar submicromolar concentrations and inhibited SERT at a concentration about eight times higher. These data support a predominantly catecholamine-transporter uptake-inhibition profile in that assay.citation needed
Uptake-inhibition IC50 values do not establish that 2-FEA is a transporter substrate or monoamine-releasing agent, and they do not determine clinical potency, dose, or safety in humans.1
Pharmacokinetics
The available transporter study is in vitro and does not provide human absorption, distribution, metabolism, elimination, bioavailability, or half-life data for 2-FEA. Human pharmacokinetics and metabolite profiles therefore remain uncharacterized by this evidence.1
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Dopaminergic stimulants
Harm Potential
Addiction & Dependence
Psychological
ModerateModerately addictive with a high potential for abuse and capable of causing psychological dependence among certain users. Compulsive redosing is reported, and cravings may develop with chronic use.
Physical
LowWithdrawal effects may occur if a person suddenly stops usage after developing addiction, though specific physical withdrawal symptoms are not well-documented. The emphasis in available literature is on psychological rather than physical dependence.
Psychosis Risk
Psychosis is listed as a potential after effect during the comedown period. Anxiety, paranoia, and delusions typically occur with overly high doses or after redosing and staying awake for extended periods, following the pattern typical of stimulant use.
History & Culture
2-FEA emerged as a novel psychoactive substance distributed through online research chemical vendors. Limited formal documentation exists regarding its precise origins, initial synthesis, or the circumstances of its introduction to the recreational drug market.…
Legality
By Country
References
Source Pages
Citations
- Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5-HT2A receptor. pubmed.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1111/bph.7058712
- National Center for Biotechnology Information. (n.d.). PubChem Compound Summary for CID 20027466, 2-Fluoroethamphetamine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/200274661
- Controlled Drugs and Substances Act, Schedule I, Item 19 — Amphetamines. (n.d.). https://laws-lois.justice.gc.ca/eng/acts/c-38.8/page-9.html1
- PubChem CID 20027466 structured compound record. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/20027466/property/IUPACName,MolecularFormula,CanonicalSMILES,IsomericSMILES/JSON1
- PubChem CID 20027466 synonyms and identifiers. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/20027466/synonyms/JSON12
- Substances vénéneuses (Listes I et II, stupéfiants, psychotropes). ansm.sante.fr (n.d.). https://ansm.sante.fr/documents/reference/substances-veneneuses-listes-i-et-ii-stupefiants-psychotropes1
- Liste consolidée des substances classées comme stupéfiants — ANSM, last updated 26 June 2026. ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/06/26/20260626-stupefiants-version-consolidee.pdf1
- Liste consolidée des substances psychotropes — ANSM, last updated 3 July 2026. ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/07/03/20260703-psychotropes-liste-consolidee.pdf1
- Les nouveaux produits de synthèse. drogues.gouv.fr (n.d.). https://www.drogues.gouv.fr/les-nouveaux-produits-de-synthese1
- Que risque-t-on pour usage de drogues ?. service-public.gouv.fr (n.d.). https://www.service-public.gouv.fr/particuliers/vosdroits/F333411
Further Reading
EMCDDA: 2-Fluoroamphetamines Technical Report (2021)
Nellis JR et al. In vitro monoamine transporter and receptor profile of fluorinated ethylamphetamines
Power JD et al. Detection of 2-FEA in post-mortem blood
Reddit: r/researchchemicals ‘2-FEA experience report’ thread (2019).
Tessel RE, Woods JH. Substituted N-ethylamphetamine self injection responding in the rhesus monkey
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
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Recent changes7 human edits · latest
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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