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2-FEA

2-FEA molecule structure2-FEA molecule structure
2-Fluoroethamphetamine
o-Fluoroethamphetamine, ortho-Fluoroethamphetamine
Psychoactive Class
Chemical Class

2-FEA is a novel synthetic stimulant of the substituted amphetamine class. It is the N-ethylated homolog of 2-fluoroamphetamine (2-FA), featuring an ethyl group bound to the terminal amine of the amphetamine backbone.citation needed 2-FEA produces classical stimulant and entactogenic effects, including stimulation, enhanced focus, and euphoria. It has limited documented history of human use and is primarily available through the online research chemical market.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~15 mg
Light20-30 mg
Moderate30-40 mg
Strong40-60 mg
Heavy60+ mg

Duration

Onset5-15 minutes
Come Up5-10 minutes
Peak30-60 minutes
Offset30-60 minutes
After Effects1-3 hours
Total1-2.5 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

The subjective effects of 2-FEA are very poorly documented, with little formal or anecdotal characterization available. What limited reporting exists describes it as a mild stimulant of the substituted amphetamine family, producing wakefulness and modest physical energy rather than a strongly recreational or perceptually altering experience.

Physical

Mild stimulation and increased wakefulness are the primary reported physical effects.

Stimulation

Wakefulness

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2 → orange1
Mandelin(MD)
yellow2 → brown1
Liebermann(LB)
white → orange2
Morr(MO)
pink2 → green1
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Pharmacology

Pharmacodynamics

In an in-vitro human monoamine-transporter uptake assay, 2-FEA inhibited DAT and NET at similar submicromolar concentrations and inhibited SERT at a concentration about eight times higher. These data support a predominantly catecholamine-transporter uptake-inhibition profile in that assay.citation needed

Uptake-inhibition IC50 values do not establish that 2-FEA is a transporter substrate or monoamine-releasing agent, and they do not determine clinical potency, dose, or safety in humans.1

Pharmacokinetics

The available transporter study is in vitro and does not provide human absorption, distribution, metabolism, elimination, bioavailability, or half-life data for 2-FEA. Human pharmacokinetics and metabolite profiles therefore remain uncharacterized by this evidence.1

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AlcoholCocaineDXMDissociativesMAOIsMDMAMXENBOMe compoundsStimulantsTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Repeated 2-FEA use over time can lead to tolerance for many effects, so similar results may require larger doses.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Moderate

Moderately addictive with a high potential for abuse and capable of causing psychological dependence among certain users. Compulsive redosing is reported, and cravings may develop with chronic use.

Physical

Low

Withdrawal effects may occur if a person suddenly stops usage after developing addiction, though specific physical withdrawal symptoms are not well-documented. The emphasis in available literature is on psychological rather than physical dependence.

Psychosis Risk

Psychosis is listed as a potential after effect during the comedown period. Anxiety, paranoia, and delusions typically occur with overly high doses or after redosing and staying awake for extended periods, following the pattern typical of stimulant use.

History & Culture

2-FEA emerged as a novel psychoactive substance distributed through online research chemical vendors. Limited formal documentation exists regarding its precise origins, initial synthesis, or the circumstances of its introduction to the recreational drug market.

Legality

By Country

Illegal3
Canada flagCanadaSchedule I (analogue)
Netherlands flagNetherlandsIllegal
United Kingdom flagUnited KingdomClass A
Controlled / restricted3
Germany flagGermanyNpSG controlled
New Zealand flagNew ZealandSchedule 3
Switzerland flagSwitzerlandControlled (Verzeichnis E)
Not scheduled1
France flagFranceNot scheduled

References

Source Pages

  1. Bluelight: ‘2-FEA Experiences’ Megathread (user dose/duration reports).
  2. Bluelight: 2-FEA Experiences and Discussion Thread
  3. Erowid: 2 Fea.shtml
  4. Erowid: 2-FEA Experience Vault
  5. Isomer Design (TiHKAL/PiHKAL)
  6. PsychonautWiki
  7. TripSit Factsheets
  8. Wikipedia

Citations

  1. Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5-HT2A receptor. pubmed.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1111/bph.7058712
  2. National Center for Biotechnology Information. (n.d.). PubChem Compound Summary for CID 20027466, 2-Fluoroethamphetamine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/200274661
  3. Controlled Drugs and Substances Act, Schedule I, Item 19 — Amphetamines. (n.d.). https://laws-lois.justice.gc.ca/eng/acts/c-38.8/page-9.html1
  4. PubChem CID 20027466 structured compound record. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/20027466/property/IUPACName,MolecularFormula,CanonicalSMILES,IsomericSMILES/JSON1
  5. PubChem CID 20027466 synonyms and identifiers. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/20027466/synonyms/JSON12
  6. Substances vénéneuses (Listes I et II, stupéfiants, psychotropes). ansm.sante.fr (n.d.). https://ansm.sante.fr/documents/reference/substances-veneneuses-listes-i-et-ii-stupefiants-psychotropes1
  7. Liste consolidée des substances classées comme stupéfiants — ANSM, last updated 26 June 2026. ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/06/26/20260626-stupefiants-version-consolidee.pdf1
  8. Liste consolidée des substances psychotropes — ANSM, last updated 3 July 2026. ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/07/03/20260703-psychotropes-liste-consolidee.pdf1
  9. Les nouveaux produits de synthèse. drogues.gouv.fr (n.d.). https://www.drogues.gouv.fr/les-nouveaux-produits-de-synthese1
  10. Que risque-t-on pour usage de drogues ?. service-public.gouv.fr (n.d.). https://www.service-public.gouv.fr/particuliers/vosdroits/F333411

Further Reading

  1. EMCDDA: 2-Fluoroamphetamines Technical Report (2021)
  2. Nellis JR et al. In vitro monoamine transporter and receptor profile of fluorinated ethylamphetamines
  3. Power JD et al. Detection of 2-FEA in post-mortem blood
  4. Reddit: r/researchchemicals ‘2-FEA experience report’ thread (2019).
  5. Tessel RE, Woods JH. Substituted N-ethylamphetamine self injection responding in the rhesus monkey

Article Status

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    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Not yet reviewed — this article is pending editorial review by Lyrea.

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    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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