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2-Chloroephenidine

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Interactions
Harm Potential
History & Culture
2-Chloroephenidine molecule structure2-Chloroephenidine molecule structure
2-Chloroephenidine
2-Cl-Eph, 2-Cl-diphenidine
Psychoactive Class
DissociativeHallucinogen
Chemical Class
Diarylethylamine (substituted)

2-Chloroephenidine is a dissociative research chemical of the diarylethylamine class and a structural analogue of ephenidine. Very little is known about this compound's pharmacology, toxicity, or subjective effect profile.citation needed It is believed to produce dissociative effects and is reported to be slightly less potent than its parent compound. Due to the near-total absence of research or documented human use, it should be approached with extreme caution.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~100 mg
Light100-130 mg
Moderate130-175 mg
Strong175-200 mg
Heavy200+ mg

Duration

Onset10-30 minutes
After Effects1-6 hours
Total3-6 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Very little is documented about this compound. As a structural analogue of ephenidine, it is considered likely to produce dissociative effects, with slightly lower potency than the parent compound.

See also: Dissociative Intensity Scale, Subjective Effects of Dissociatives

Pharmacology

Pharmacodynamics

Binding Sites
NMDA receptorantagonistnoncompetitive

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Dissociatives, NMDA receptor antagonists

Harm Potential

Harm Potential not written up yet

History & Culture

History & Culture not written up yet

Legality

International

As of 23 August 2026, 2-Chloroephenidine (2-(2-chlorophenyl)-N-ethyl-1-phenylethylamine) is not named or chemically designated in the current complete INCB Yellow, Green or Red Lists. The Green List instead places diphenidine, chemically designated as 1-(1,2-Diphenylethyl)piperidine, in Schedule II. That entry does not cover 2-Chloroephenidine: diphenidine contains a piperidine ring, while 2-Chloroephenidine is an open-chain N-ethylamine with an ortho-chloro substituent. The Green List's stereoisomer guidance applies within the specific chemical designation of a scheduled substance, not to constitutionally distinct analogues. INCB's March 2026 notice adds only MDMB-FUBINACA to Schedule II, with effect from 25 November 2026, and does not name 2-Chloroephenidine. Accordingly, the current INCB materials establish no scheduling of 2-Chloroephenidine under the 1961, 1971 or 1988 conventions.

By Country

Illegal12
Argentina flagArgentinaIllegal (analog/blanket ban)
Australia flagAustraliaIllegal (analog/blanket ban)
Austria flagAustriaIllegal (analog/blanket ban)
Brazil flagBrazilIllegal (analog/blanket ban)
Canada flagCanadaIllegal (analog/blanket ban)
Germany flagGermanyIllegal (analog/blanket ban)
Netherlands flagNetherlandsIllegal (analog/blanket ban)
Poland flagPolandIllegal (analog/blanket ban)
Russia flagRussiaIllegal (analog/blanket ban)
Singapore flagSingaporeIllegal (analog/blanket ban)
South Africa flagSouth AfricaIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)

References

Source Pages

  1. Bluelight: New dissociative RCs thread (2014-2015)
  2. Bluelight: TR – 100 mg rectal 2-Cl-Eph (2015)
  3. Designing novel diarylethylamines overview (Bluelight, 2020)
  4. List of designer drugs – diarylethylamines
  5. PiHKAL.info - 2-Chloroephenidine (IUPAC & molecular data)
  6. TripSit: Factsheet - 2-Chloroephenidine

Citations

  1. Decreto 560/2019, artículo 2 y Anexo II (Grupo 15: Fenetilaminas sustituidas). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
  2. Decreto 560/2019, artículo 2 y Anexo II (Grupo 15: Fenetilaminas sustituidas). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/326675_dec560-2_pdf/archivo1
  3. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, section 7 and Schedule 9. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
  4. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, section 7 and Schedule 9. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2024L01228/asmade/2024-09-30/es/original/epub/OEBPS/document_1/document_1.html1
  5. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, section 7 and Schedule 9. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/compound/434890921
  6. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), § 1 Abs. 1 Z 2 and Abs. 2, Anlage II Z 2; Neue-Psychoaktive-Substanzen-Gesetz (NPSG), § 4. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/BgblAuth/BGBLA_2024_II_106/Anlagen_0001_BA9813D3_0B74_48C4_93B4_C711A2708880.pdf1
  7. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), § 1 Abs. 1 Z 2 and Abs. 2, Anlage II Z 2; Neue-Psychoaktive-Substanzen-Gesetz (NPSG), § 4. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/eli/bgbl/ii/2011/468/P1/NOR401871781
  8. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), § 1 Abs. 1 Z 2 and Abs. 2, Anlage II Z 2; Neue-Psychoaktive-Substanzen-Gesetz (NPSG), § 4. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/eli/bgbl/i/2011/146/P4/NOR401344471
  9. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), § 1 Abs. 1 Z 2 and Abs. 2, Anlage II Z 2; Neue-Psychoaktive-Substanzen-Gesetz (NPSG), § 4. drugs.ncats.io (n.d.). https://drugs.ncats.io/drug/H6G56R5EWK12345
  10. Portaria SVS/MS nº 344/1998, Anexo I, Lista F2, item a(100) and Adendo 1.1, as republished by RDC Anvisa nº 1.036/2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/UrlPublicasAction.php?acao=abrirAtoPublico&num_ato=00001036&sgl_tipo=RDC&sgl_orgao=RDC/DC/ANVISA/MS&vlr_ano=2026&seq_ato=000&cod_modulo=134&cod_menu=16961

Further Reading

  1. Enantiomeric separation of diphenidine derivatives (J Chromatogr B 2025)
  2. French Addictovigilance Network – phenidine complications (2019)
  3. Journal of Psychopharmacology - Pharmacological investigations of diphenidine analogues (2016)
  4. NCATS Inxight entry – 2-Chloro-ephenidine
  5. Nervewing: Diarylethylamines overview (2020)
  6. Pharmacological investigations of diphenidine analogues (J Psychopharmacol 2016)
  7. PLOS ONE - Pharmacological Investigations of Dissociative 'Legal Highs' (2016)
  8. PubChem: 2 Chloro ephenidine
  9. Receptor-binding heat-map of diarylethylamines (2016)
  10. Reddit: r/researchchemicals binding-affinity thread (2023)
  11. Structure–activity summary of diarylethylamines (ResearchGate 2024)
  12. UK ACMD - Diphenidine diarylethylamine review (2023)
  13. UK ACMD diarylethylamine report (2023)
  14. Wiley NPS laboratory testing review (2023)

Article Status

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Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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