1,2-Diarylethylamine (diarylethylamines)

Diarylethylamines are a chemical class of organic compounds built on a two-carbon ethylamine chain that bears two aromatic aryl rings, one on each of the two carbons, in the 1,2-diarylethylamine arrangement. The amine is frequently incorporated into a ring such as piperidine or pyrrolidine, or left as a simple N-ethyl group, and ring substituents such as methoxy groups distinguish the members. Most diarylethylamines act as dissociatives through antagonism of the NMDA receptor. They are close structural cousins of the arylcyclohexylamines, achieving a similar aryl-plus-amine layout using an open two-aryl ethyl chain rather than a cyclohexane ring.