Skip to main content
Lyrea avatar

Not yet reviewed — this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

Nitemazepam

Nitemazepam molecule structureNitemazepam molecule structure

Nitemazepam is a novel research chemical of the benzodiazepine class, structurally derived from nimetazepam. Very limited information is available regarding its pharmacology, safety profile, or effects. Anecdotal reports suggest it may produce effects comparable to temazepam. As with other benzodiazepines, it is considered habit-forming. Due to the scarcity of data surrounding this substance, users should exercise extreme caution, as its risks and safe dosage range remain poorly understood.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~1 mg
Light1-1.5 mg
Moderate1.5-3 mg
Strong3-5 mg
Heavy5+ mg

Duration

Onset15-45 minutes
After Effects1-12 hours
Total6-12 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Documentation of the subjective experience is extremely limited. Anecdotal reports suggest the effects resemble those of temazepam.

Pharmacology

Pharmacodynamics

Nitemazepam is a benzodiazepine derivative and the 7-nitro analogue of temazepam, as well as the 3-hydroxy derivative of nimetazepam. It is also an active metabolite of nimetazepam. Detailed receptor binding data and functional pharmacodynamic characterization are not available in the current literature.

Pharmacokinetics

Nitemazepam is metabolized to several products including 7-aminonitemazepam, nimetazepam, 3-hydroxynitemazepam, temazepam, and nimetazepam glucuronide. No specific metabolic enzymes or pharmacokinetic parameters have been characterized in the available literature.

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Benzodiazepines

Harm Potential

Addiction & Dependence

Psychological

Classified as habit-forming.

History & Culture

Nitemazepam, also known as 3-hydroxynimetazepam, is a benzodiazepine derivative that was originally synthesized during the 1970s. Despite its early development, the compound was never brought to market as a pharmaceutical product.

Legality

Legality not written up yet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the Nitemazepam article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.