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Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
ModerateAlthough users often report disliking MT-45 and few describe sustained use, addiction can still occur. Some users may feel pushed to take additional doses before onset or during the comedown.
Toxicity
MT-45 produces auditory issues in what appears to be a far more reliable manner than other opioids, with reports of tinnitus and hearing loss; in documented overdose cases, some individuals experienced transient hearing loss while at least one case involved persistent bilateral hearing loss that remained problematic at two-week follow-up, suggesting potential for very long-lasting or permanent damage.
Recreational use has been associated with unusual dermatological effects including hair depigmentation, alopecia, and skin and nail reactions such as dermatitis and Mees lines; these effects are not typically seen with other opioid agonists.
Recreational use has been associated with cataracts, an unusual side effect not typically seen with other opioid agonists.
History & Culture
Legality
By Country
References
Citations
- e-Sbírka open data: current consolidated Annex 3 table to Government Regulation No. 463/2013 Coll.. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/12364394931
- e-Sbírka open data: heading of Annex 3 to Government Regulation No. 463/2013 Coll.. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/3014611231
- e-Sbírka open data: Government Regulation No. 463/2013 Coll., § 1(c)(2). opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/84244311
- e-Sbírka open data: Act No. 167/1998 Coll., § 4. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/39359631
- Misuse of Drugs Act 1971, Schedule 2 — Controlled Drugs. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- Home Office: List of most commonly encountered drugs currently controlled under the misuse of drugs legislation. gov.uk (n.d.). https://www.gov.uk/government/publications/controlled-drugs-list--2/list-of-most-commonly-encountered-drugs-currently-controlled-under-the-misuse-of-drugs-legislation1
- Misuse of Drugs Act 1971 (Amendment) Order 2015, article 3. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2015/215/article/3/made1
- Home Office Circular 003/2015: control of MT-45 and 4,4’-DMAR. gov.uk (n.d.). https://www.gov.uk/government/publications/circular-0032015-a-change-to-the-misuse-of-drugs-act-1971-control-of-mt-45-and-44-dmar1
- Misuse of Drugs Regulations 2001, Schedule 1. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2001/3998/schedule/11
- Misuse of Drugs (Amendment) (England, Wales and Scotland) Regulations 2015. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2015/231/made1
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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