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MK-801
MK-801 is a dissociative research chemical reported to resemble PCP and ketamine in its effects. It is classified as habit-forming.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
Dizocilpine is a potent uncompetitive NMDA receptor antagonist that blocks the receptor's open ion channel. It binds within the channel at PCP-associated sites in a use- and voltage-dependent manner, preventing ions, including calcium, from passing through. It also antagonizes nicotinic acetylcholine receptors and binds to and inhibits the serotonin and dopamine transporters.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Dizocilpine produced reinforcing behavior in animal studies, including self-administration, conditioned place preference, and increased self-stimulation responding. Three of four rhesus monkeys previously trained with phencyclidine self-administered dizocilpine, while none of four monkeys previously trained with cocaine did so.
Toxicity
Dizocilpine's high potency makes dose control difficult and increases the likelihood of overdose.
In laboratory rats, a single subcutaneous dose of 1 mg/kg produced neuronal vacuolization in the posterior cingulate and retrosplenial cortex within 30 minutes, followed by neuronal necrosis.
Psychosis Risk
Dizocilpine can produce psychotic-spectrum and psychotomimetic reactions, including hallucinations, during use.
History & Culture
A team at Merck discovered dizocilpine in 1982. The compound was investigated as a potential neuroprotective agent, but Merck ended its development after brain lesions were observed in laboratory rats. John W. Olney first identified this lesion pattern in 1989.…
Legality
References
Source Pages
Further Reading
Article Status
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