Methoxyketamine
Methoxyketamine is a dissociative research chemical of the arylcyclohexylamine class and a structural analogue of ketamine. It is reported to produce dissociative and anesthetic effects comparable to those of ketamine, though at a slightly lower potency. The substance is considered extremely rare, with very limited availability and documentation. As with other dissociatives in its class, it may carry habit-forming potential.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Effects are described as closely resembling those of ketamine, with dissociation and, at sufficient doses, anesthesia as the defining features. Potency is somewhat lower than ketamine's, so comparable effects require larger amounts. Sedation and hallucinogenic effects are also reported, with anesthesia emerging only at high doses.
Physical
Sedation is a reported physical effect, progressing to anesthesia at high doses.
Cognitive
The state is described as dissociative, mirroring the headspace associated with ketamine.
Reagent Testing
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Pharmacology
Pharmacodynamics
Methoxyketamine is an arylcyclohexylamine and a structural analog of ketamine in which the chlorine atom has been replaced with a methoxy group. Based on its arylcyclohexylamine structure, methoxyketamine most likely acts as an NMDA receptor antagonist, though its precise receptor pharmacology has not been well characterized. It is reported to be less potent than ketamine.
Pharmacokinetics
Tolerance
Dissociatives, NMDA receptor antagonists
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming, suggesting some potential for psychological dependence, though specific details on addiction liability are not documented.
History & Culture
Methoxyketamine was first documented in the scientific literature in 1963, making it one of the earlier arylcyclohexylamine compounds to be described. The substance represents a structural analog of ketamine in which the chlorine atom has been substituted with a methoxy group. Chemical literature…
Legality
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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