Isomethadone
Isomethadone is a synthetic opioid analgesic structurally related to methadone. It was formerly available as a pharmaceutical product but has since been withdrawn from the market and is seldom encountered today. It is reported to possess approximately twice the analgesic potency of methadone and is said to produce euphoric effects. As with other opioids, it carries a risk of habit formation and respiratory depression.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Isomethadone produces a classic opioid experience centered on euphoria, mood lift, and physical relaxation, consistent with its status as a structural analogue of methadone. As a withdrawn pharmaceutical that is seldom encountered today, detailed experience reports are scarce, but the available accounts describe a euphoric, analgesic effect profile accompanied by the typical constellation of opioid side effects.
Physical
The body experience is dominated by pain relief and a relaxed, comfortable heaviness, alongside common opioid side effects such as itchiness, dry mouth, constipation, and constricted pupils.
Bodily
Uncomfortable
Side effects typical of opioids accompany the experience.
Cognitive
The mental state is characterized by euphoria and an elevated mood, without notable alteration of perception or thought structure.
Reagent Testing
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Pharmacology
Pharmacodynamics
Isomethadone acts as an agonist at both the μ-opioid and δ-opioid receptors. The (S)-enantiomer is reported to be more potent than the (R)-enantiomer.
Pharmacokinetics
Tolerance
Opioids
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming.
History & Culture
Isomethadone, also known by the alternative name isoamidone, is a synthetic opioid analgesic structurally related to methadone. It was previously marketed as a pharmaceutical product under the trade name Liden, where it saw clinical use for both pain management and cough suppression. The compound has since been withdrawn from the pharmaceutical market and is no longer commercially available as a medication.
Legality
International
UN Single Convention on Narcotic Drugs 1961 (Schedule I)
By Country
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