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Flmodafinil

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Harm Potential
Legality
Flmodafinil molecule structureFlmodafinil molecule structure
Bisfluoromodafinil
Lauflumide, CRL-40,940, NLS-4
Psychoactive Class
EugeroicStimulantNootropic

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~25 mg
Light50-100 mg
Moderate100-150 mg
Strong150-200 mg
Heavy200+ mg

Duration

Onset30-60 minutes
Peak4-8 hours
Total8-12 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Flmodafinil acts as a selective, atypical dopamine reuptake inhibitor. It binds to the dopamine transporter (DAT) with a Ki of 4,090 nM1 and has been shown to block DAT by 83%citation needed. Its affinity for the serotonin transporter is approximately 12-fold lower than for the DAT, and it has negligible affinity for the sigma-1 receptor. In animal models, flmodafinil increases dopamine levels in the nucleus accumbens by up to 150 to 200% of baseline at the highest assessed doses.

Pharmacokinetics

Flmodafinil does not induce the cytochrome P450 enzymes CYP3A4 or CYP3A5.

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

Flmodafinil, also known as lauflumide, CRL-40,940, and NLS-4citation needed, has been developed as a potential pharmaceutical wakefulness-promoting agent while also being sold online for non-medical nootropic use.

Development

Flmodafinil was developed by NLS Pharma and has been investigated for conditions including chronic fatigue syndrome, idiopathic hypersomnia, narcolepsy, ADHD, and Alzheimer's disease. As of January 2024, it was described as in preclinical development for chronic fatigue syndrome, with no recent

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: ‘Cutting-edge modafinil analogues’ thread – user Rifter2 40 mg report
  2. Bluelight: Modafinil Analogues User Reports
  3. PsychonautWiki: Lauflumide
  4. TripSit: CRL-40-940 Factsheet
  5. Wikipedia: Flmodafinil

Citations

  1. National Center for Biotechnology Information. (n.d.). PubChem Compound Summary for CID 13271852, Flmodafinil. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/13271852123
  2. Luca G, Bandarabadi M, Konofal E, Lecendreux M, Ferrié L, Figadère B, & Tafti M. (2018). Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound. Frontiers in Neuroscience, 12, Article 519. https://doi.org/10.3389/fnins.2018.005191

Further Reading

  1. Flmodafinil.pl – recommended 50–100 mg once-daily guideline
  2. Keighron et al. 2019 - Effects of (R)-modafinil and fluoro-analogs on mesolimbic dopamine (DOI)
  3. Konofal 2024 - 50 years of pharmacological interventions for narcolepsy (DOI)
  4. Modafinil.com – Flmodafinil benefits, potency & half-life
  5. Modafinil.org – Flmodafinil dosage guide
  6. Neuropharmacology 2019 – EEG classification of atypical DRIs
  7. Purity vendor note – longer half-life & bioavailability
  8. Reddit: r/Afinil - Insufflating CRL-40-940 Discussion
  9. The Psychonauts’ World of Cognitive Enhancers – review of novel afinils
  10. Zanettini et al. 2019 - EEG classification of atypical dopamine uptake inhibitors (DOI)

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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