No reaction
No reactionNot yet reviewed — this article is pending editorial review by Lyrea.
WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged dependency, stopping suddenly can also cause seizures or delirium; seek medical help.
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References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~0.5 mg
Light0.5-1 mg
Moderate1-2 mg
Strong2-4 mg
Heavy4+ mg
Duration
Onset30-60 minutes
After Effects2-24 hours
Total7-12 hours
Subjective Effects
Subjective Effects not written up yet
Pharmacology
Pharmacology not written up yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance not written up yet
Harm Potential
Addiction & Dependence
Psychological
HighEstazolam has demonstrated abuse potential in primate studies. As a benzodiazepine, it carries significant risk of psychological dependence, with recreational misuse occurring to achieve intoxication or continued use against medical advice being documented patterns of misuse.
Physical
HighPhysical dependence is a primary safety concern with estazolam. Long-term use is associated with drug dependence and a benzodiazepine withdrawal syndrome upon discontinuation. Tolerance to hypnotic effects develops within days, particularly in elderly users.
Toxicity
Central Nervous System
Acute CNS depression occurs during use, with symptoms including somnolence, dizziness, hypokinesia, abnormal coordination, and next-day hangover effects impairing mental and physical performance; overdose can progress to confusion, depressed breathing, and coma.
History & Culture
History & Culture not written up yet
Legality
By Country
Illegal1
United StatesIllegalEstazolam is listed by exact name in federal Schedule IV under the Controlled Substances Act, implemented at 21 C.F.R. § 1308.14(c)(21). The schedule covers any quantity of estazolam, including its salts, isomers, and salts of isomers where chemically possible, unless specifically excepted or listed in another schedule. Federal law controls possession, manufacture, distribution, dispensing, import, export, and possession with intent to manufacture, distribute, or dispense; simple possession pursuant to a valid prescription or order, and other authorized possession, is excepted. The classification took effect on November 5, 1984.
Controlled / restricted1
CanadaRestrictedEstazolam is expressly listed under benzodiazepines in Schedule IV, item 18(11), of the Controlled Drugs and Substances Act. Ordinary possession is not prohibited by subsection 4(1), which applies only to substances in Schedules I, II, and III. Schedule IV substances remain subject to prohibitions on trafficking, possession for trafficking, unauthorized import or export, possession for export, unauthorized production, and obtaining a substance from a practitioner without the disclosure required by subsection 4(2). The Act came into force on May 14, 1997.
References
Citations
- Controlled Drugs and Substances Act — Schedule IV. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95660.html1
- Controlled Drugs and Substances Act — section 4. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-4.html1
- Controlled Drugs and Substances Act — section 5. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-5.html1
- Controlled Drugs and Substances Act — section 6. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-6.html1
- Controlled Drugs and Substances Act — section 7. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-7.html1
- Benzodiazepines and Other Targeted Substances Regulations — Schedule 1, Part 1. laws-lois.justice.gc.ca (n.d.). https://www.laws-lois.justice.gc.ca/eng/regulations/SOR-2000-217/FullText.html1
- Health Canada Drug Product Database — PROSOM TAB 1MG. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/info?code=14317&lang=eng1
- Health Canada Drug Product Database — PROSOM TAB 2MG. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/search-fast-recherche-rapide?lang=eng&no=01168700021
- The Prescription Drug List: Access the list and notices. canada.ca (n.d.). https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/prescription-drug-list/access-list-notices.html1
- Controlled Drugs and Substances Act — coming into force. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-8.html1
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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