EPT
EPT is an obscure synthetic psychedelic of the tryptamine class1, structurally related to DMT2, DET, and DPT. Its original synthesis date is unknown, with the compound first appearing on the research chemical market in 2016. Notably, EPT has no documentation in the scientific literature and appears to be entirely a product of clandestine drug design. Early reports characterize its effects as mild and indistinct compared to related base tryptamines, most closely resembling a less potent DPT.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
EPT is a rarely encountered psychedelic tryptamine, and its subjective effects remain sparsely documented. The limited anecdotal record describes a classic serotonergic psychedelic profile broadly in line with its close structural relatives such as DET and DPT, with visual alterations and a psychedelic headspace of relatively moderate character. Detailed phenomenological documentation has not yet been established for this compound.
Cognitive
The headspace is described as a characteristic psychedelic state, including mood elevation and an altered sense of the passage of time.
Visual
Visual effects are consistent with those of other psychedelic tryptamines, scaling with dose.
Reagent Testing
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Pharmacology
Pharmacodynamics
EPT is thought to act principally as a partial agonist at the serotonin 5-HT2A receptor, which is believed to underlie its psychedelic effects.3 Like other serotonergic tryptamines, EPT shares strong structural similarity with serotonin itself, which contributes to its affinity for 5-HT receptor sites.
Pharmacokinetics
Tolerance
Psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowAnecdotal reports suggest EPT has low abuse potential and does not produce dependence, similar to other unsubstituted tryptamines such as DMT, DET, and MET.
Physical
Extremely LowAnecdotal reports suggest EPT does not produce physical dependence.
History & Culture
EPT's original synthesis date remains unknown. The compound first appeared for sale on the online research chemical market in 2016, emerging as what appears to be an entirely novel product of clandestine drug design rather than a compound derived from academic or pharmaceutical research. Unlike…
Legality
By Country
References
Source Pages
Citations
- Bergh MS-S, Bogen IL, Grafinger KE, Huestis MA, & Øiestad AML. (2024). Metabolite markers for three synthetic tryptamines N-ethyl-N-propyltryptamine, 4-hydroxy-N-ethyl-N-propyltryptamine, and 5-methoxy-N-ethyl-N-propyltryptamine. Drug Testing and Analysis. https://doi.org/10.1002/dta.366812
- Chadeayne AR, Pham DNK, Golen JA, & Manke DR. (2020). DMT analogues: N-ethyl-N-propyltryptamine and N-allyl-N-methyltryptamine as their hydrofumarate salts. Acta Crystallographica Section E: Crystallographic Communications, 76(8), 1201–1205. https://doi.org/10.1107/s20569890200086831
- Manier, Sascha K., Felske, Christina, Zapp, Josef, Eckstein, Niels, & Meyer, Markus R.. (2021). Studies on the In Vitro and In Vivo Metabolic Fate of the New Psychoactive Substance N-Ethyl-N-Propyltryptamine for Analytical Purposes. Journal of Analytical Toxicology, 45(2), 195–202. https://doi.org/10.1093/jat/bkaa0601
- Tanaka R, Kawamura M, Hakamatsuka T, & Kikura-Hanajiri R. (2021). Identification of six tryptamine derivatives as designer drugs in illegal products. Forensic Toxicology, 39, 248–258. https://doi.org/10.1007/s11419-020-00556-51
- (n.d.). Änderungen NpSG vom 18.07.2019 – Anlage des Neue-psychoaktive-Stoffe-Gesetzes. buzer.de. https://www.buzer.de/gesetz/12250/v224771-2019-07-18.htm1
- (n.d.). Misuse of Drugs Act 1971, Schedule 2 – Controlled Drugs. legislation.gov.uk. https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- (n.d.). 21 U.S. Code § 813 – Treatment of Controlled Substance Analogues. Legal Information Institute, Cornell Law School. https://www.law.cornell.edu/uscode/text/21/8131
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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