DPT

N,N-Dipropyltryptamine

The Light

Psychoactive Class

Chemical Class

DPT is a synthetic psychedelic of the tryptamine class¹, closely related to DMT. First described in the scientific literature by the late 1950s, it was subsequently investigated during the 1970s as an adjunct in therapeutic settings for alcoholism² and to facilitate peak experiences in terminal cancer patients. DPT is noted for producing hallucinogenic effects comparable in intensity to DMT, though with greater unpredictability and wider individual variation in response at any given dose.

Dosage & Duration

Dosage

Threshold~50 mg

Light50-125 mg

Moderate125-250 mg

Strong250-350 mg

Heavy350+ mg

Oral bioavailability is relatively low, and individual responses can vary considerably. The onset of effects is influenced by whether the stomach is empty or contains food.

Duration

Onset20-60 minutes

After Effects2-3 hours

Total2-4 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

At light to moderate doses, there is often a slight sense of anaesthetization and relaxation. As the dose increases, perceptions of heart rate increase and body tremors and loss of muscle control are often reported. DPT can range from strong euphoria and erotiscism to nausea and dysphoria even within the same trip.

Headaches Motor control loss Muscle spasms Nausea Physical euphoria Wakefulness

Cognitive

Emotion enhancement Memory suppression Ego death Novelty enhancement Personal bias suppression Rejuvenation Subconscious communication Unity and interconnectedness

Visual

Distortions

After images Colour replacement Colour shifting Recursion Scenery slicing Symmetrical texture repetition Tracers

Enhancements

Colour enhancement Pattern recognition enhancement Acuity enhancement

Hallucinatory States

DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic.

Machinescapes Transformations

Forked from Subjective Effect Documentation

by Josie KinsJuly 2016.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

DPT acts primarily as a serotonin 5-HT2A receptor agonist.¹³ In rodent studies, selective 5-HT2A receptor antagonists effectively block the behavioral actions of the compound, and in discriminative stimulus assays DPT fully substitutes for DOM with this substitution likewise blocked by 5-HT2A antagonism. The modulatory effects of a 5-HT1A receptor antagonist suggest an additional 5-HT1A-mediated component, with partial agonism at this receptor proposed. DPT is an agonist at several serotonin receptors in vitro, though its full receptor interaction profile remains incompletely characterized. Research in mouse models of fragile X syndrome has found that certain pharmacological actions of DPT appear to be independent of serotonin 5-HT2A, 5-HT1A, 5-HT1B, and sigma-1 receptor activation, suggesting the compound may also act through non-serotonergic pathways.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

LithiumStimulantsTramadol

TripSit

Tolerance

Full Tolerance

Unlike most psychedelics, DPT does not appear to produce significant tolerance with repeated use. Animal studies have demonstrated that tolerance to DPT's effects does not develop, and human reports suggest only minimal tolerance building compared to other tryptamines.

Cross Tolerance

DMT (reported slight cross-tolerance, though less pronounced than with other psychedelics)

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

DPT is not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is reported to be self-limiting.⁴

Physical

Extremely Low

No physical dependence or withdrawal symptoms have been documented. The substance is reported to be self-limiting like other psychedelic tryptamines.⁴

Psychosis Risk

There is some potential for temporary psychosis during the experience. Transient anxiety and paranoia are more commonly reported adverse psychological effects. The substance is considered more psychologically challenging than many other psychedelics, with experiences often described as 'bizarre' and 'unsettling.' Those with existing psychiatric disorders should avoid this substance.⁵

Seizure Risk

One death has been associated with DPT and seizures, though the dose is unknown. Animal research indicates complex dose-dependent effects: at lower doses DPT demonstrated anticonvulsant properties in mouse models, while at higher doses it switched to proconvulsant action.⁶ Psychedelics may act as triggers for seizures in predisposed individuals.

History & Culture

Synthesis and Early Research

DPT was first synthesized in 1950, with initial pharmacological testing conducted in dogs by 1954. The compound was formally described in scientific literature by 1959, and human trials during the 1960s confirmed its hallucinogenic properties. By 1968, DPT had been identified as a novel designer

Trip Reports

Legality

By Country

United StatesFederally unscheduled (state exceptions)

DPT remains unscheduled at the federal level, meaning possession, purchase, and distribution are generally legal under federal law. However, several states have independently scheduled the substance: Florida classifies it as Schedule I, Maine lists it as Schedule X, and Oklahoma has placed it in Schedule I. The Federal Analogue Act may apply if sold for human consumption.

GermanyNpSG (Neue-psychoaktive-Stoffe-Gesetz)

Controlled under the New Psychoactive Substances Act as of July 18, 2019.⁸ Production and importation with intent to market, administration to others, and trading are criminally punishable.⁹ Possession is prohibited but not subject to criminal penalty.

JapanDesignated Substance (Shitei-Yakubutsu)

Controlled under the Pharmaceutical Affairs Law. Possession and sale are prohibited.

New ZealandClass C

Controlled as a Class C substance due to its structural relationship to DMT, which is explicitly scheduled. The analogue provisions extend control to structurally similar tryptamines.¹⁰

SwedenNarcotic substance

Classified as a narcotic substance on January 26, 2016 following its sale as a designer drug.¹¹ Manufacturing, trade, and possession are prohibited.

United KingdomClass A

Controlled under the Misuse of Drugs Act 1971 through the tryptamine catch-all clause, which covers compounds structurally derived from tryptamine by substitution at the nitrogen atom of the sidechain with alkyl substituents.¹² Class A classification carries the most severe penalties for possession, production, and distribution.

BelgiumSchedule I equivalent

Listed in Belgium's most restrictive controlled substance category, approximately equivalent to Schedule II under the United States system. Manufacturing, distribution, and possession are prohibited.

GreeceControlled substance

Became a controlled substance on February 18, 2003 under national drug legislation.

LatviaSchedule I

Classified as a Schedule I controlled substance under national drug legislation. Possession, distribution, and production are illegal.

PortugalTable II-A

Listed in Table II-A of the controlled substances tables alongside substances such as MDMA and LSD. Production and trafficking remain illegal; personal possession of small quantities is decriminalized under Portuguese drug policy.

SwitzerlandVerzeichnis E

Specifically named as a controlled substance under Verzeichnis E (Schedule E) of Swiss narcotics legislation. Unauthorized possession, production, and distribution are prohibited.

References

Source Pages

Citations

Automated synthesis
Information aggregated and synthesized using an autonomous workflow built by Josie Kins.

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DPT

N,N-Dipropyltryptamine

The Light

Psychoactive Class

Psychedelic Hallucinogen

Chemical Class

Tryptamine