DPT
DPT is a synthetic psychedelic of the tryptamine class1, closely related to DMT. First described in the scientific literature by the late 1950s, it was subsequently investigated during the 1970s as an adjunct in therapeutic settings for alcoholismcitation needed and to facilitate peak experiences in terminal cancer patients. DPT is noted for producing hallucinogenic effects comparable in intensity to DMT, though with greater unpredictability and wider individual variation in response at any given dose.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Oral bioavailability is relatively low, and individual responses can vary considerably. The onset of effects is influenced by whether the stomach is empty or contains food. Community reference timings for this route are contextual rather than clinical: PsychonautWiki lists oral total 2–4 hours, onset 20–60 minutes, and after-effects 2–3 hours, and does not establish come-up, peak, or offset values.2
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
At light to moderate doses, there is often a slight sense of anaesthetization and relaxation. As the dose increases, perceptions of heart rate increase and body tremors and loss of muscle control are often reported. DPT can range from strong euphoria and erotiscism to nausea and dysphoria even within the same trip.
Cognitive
Visual
Distortions
Hallucinatory States
DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic.
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
DPT acts primarily as a serotonin 5-HT2A receptor agonist.citation needed In rodent studies, selective 5-HT2A receptor antagonists effectively block the behavioral actions of the compound, and in discriminative stimulus assays DPT fully substitutes for DOM with this substitution likewise blocked by 5-HT2A antagonism. The modulatory effects of a 5-HT1A receptor antagonist suggest an additional 5-HT1A-mediated component, with partial agonism at this receptor proposed. DPT is an agonist at several serotonin receptors in vitro, though its full receptor interaction profile remains incompletely characterized. Research in mouse models of fragile X syndrome has found that certain pharmacological actions of DPT appear to be independent of serotonin 5-HT2A, 5-HT1A, 5-HT1B, and sigma-1 receptor activation, suggesting the compound may also act through non-serotonergic pathways.
Pharmacokinetics
Controlled pharmacokinetic studies have not characterized DPT in humans or other species. A 2024 fatal intoxication report measured DPT at approximately 210 ng/mL in serum collected four hours after reported intranasal use, 110 ng/mL in postmortem cardiac blood, and 180 ng/mL in urine. Because the consumed dose was unknown and the report did not provide serial concentration-time sampling, it does not establish route bioavailability, clearance, elimination half-life, or metabolic pathways; those parameters remain unknown.citation needed
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
DMT (reported slight cross-tolerance, though less pronounced than with other psychedelics)
Harm Potential
Addiction & Dependence
Psychological
Extremely LowDPT is not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is reported to be self-limiting.citation needed
Physical
Extremely LowNo physical dependence or withdrawal symptoms have been documented. The substance is reported to be self-limiting like other psychedelic tryptamines.citation needed
Psychosis Risk
There is some potential for temporary psychosis during the experience. Transient anxiety and paranoia are more commonly reported adverse psychological effects. The substance is considered more psychologically challenging than many other psychedelics, with experiences often described as 'bizarre' and 'unsettling.' Those with existing psychiatric disorders should avoid this substance.citation needed
Seizure Risk
One death has been associated with DPT and seizures, though the dose is unknown. Animal research indicates complex dose-dependent effects: at lower doses DPT demonstrated anticonvulsant properties in mouse models, while at higher doses it switched to proconvulsant action.7 Psychedelics may act as triggers for seizures in predisposed individuals.
History & Culture
Synthesis and Early Research
DPT was first synthesized in 1950, with initial pharmacological testing conducted in dogs by 1954. The compound was formally described in scientific literature by 1959, and human trials during the 1960s confirmed its hallucinogenic properties. By 1968, DPT had been identified as a novel designer
Trip Reports
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Legality
International
DPT is not individually listed in the current schedules to the 1961 Single Convention, the 1971 Convention on Psychotropic Substances, or the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
By Country
References
Source Pages
Citations
- Fantegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, & Winter JC. (2008). Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacology Biochemistry and Behavior, 88(3), 358-365. https://doi.org/10.1016/j.pbb.2007.09.0071
- Community substance factsheet; retrieved 2026-08-16. psychonautwiki.org (n.d.). https://psychonautwiki.org/wiki/DPT1234
- Created 1998; modified 2015; accessed 2026-08-16. erowid.org (n.d.). https://www.erowid.org/chemicals/dpt/dpt_dose.shtml123
- DPT structured drug record. tripbot.tripsit.me (n.d.). https://tripbot.tripsit.me/api/tripsit/getDrug/DPT123
- Dipropyltryptamine (DPT). thedrugclassroom.com (n.d.). https://thedrugclassroom.com/video/dipropyltryptamine-dpt/123
- Low doses of dipropyltryptamine in psychotherapy. doi.org (n.d.). https://doi.org/10.1001/archpsyc.1973.017503600470061
- Gatch MB, & Forster MJ. (2023). The Psychedelic N,N-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors. https://doi.org/10.1021/acsptsci.3c001371
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest/text1
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest/details1
- Royal Decree of 6 September 2017 regulating narcotic and psychotropic substances. ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
Article Status
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Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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