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Dopr

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Subjective Effects
Interactions
Tolerance
Legality
Dopr molecule structureDopr molecule structure
Chemical Class
DOx

DOPR is a rare psychedelic amphetamine in the DOx, phenethylamine, and amphetamine families, related to DOM. It differs from DOM by replacing the 4-position methyl group with a propyl group1. The substance produces psychedelic effects2 and has been described as a potent, “heavy duty” psychedelic.3 Alexander Shulgin first described it in the literature in 1970.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold1.25 mg
Light2.5 mg
Moderate2.5-3.5 mg
Heavy3.5-5 mg

Duration

Onset1.5-4 hours
After Effects1-24 hours
Total18-30 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → brown1
Mecke(ME)
white → brown2 → green2
Mandelin(MD)
yellow2 → green2
Liebermann(LB)
white → green3
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Pharmacology

Pharmacodynamics

DOPR acts as a serotonin 5-HT2A receptor agonist2. It is described more broadly as an agonist at 5-HT2 receptors, including 5-HT2A, 5-HT2B, and 5-HT2C.4 In mice, DOPR induced a significant head-twitch response only at doses ≥0.1 mg/kg in an assay described as a preclinical readout of psychedelic potential2, with slightly greater potency but slightly lower efficacy than DOM. It crosses the blood–brain barrier in rodents4 and showed the highest brain-to-plasma ratio among the assessed DOM homologues.4

Pharmacokinetics

DOPR is taken orally and crosses the blood–brain barrier in rodents. Among the assessed DOM homologues, it showed the highest brain-to-plasma ratio.

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Central Nervous System

At higher doses, nervous system disturbances have been reported, described as 'nervous system scrungies' that interfere with relaxation and sleep; these effects appear to be dose-dependent and associated with doses at the upper end of the active range.

Thermoregulation

Higher doses produce hypothermia in rodent models, suggesting potential for body temperature dysregulation.

History & Culture

Early documentation

Alexander Shulgin first described DOPR in the scientific literature in 1970. He later discussed the compound in greater detail in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).3

Legality

Legality not written up yet

References

Citations

  1. The 4-Alkyl-2,5-dimethoxyamphetamines. Journal of Medicinal Chemistry (1975). https://www.thevespiary.org/rhodium/Rhodium/pdf/shulgin/shulgin.4-alkyl-25-dma.pdf1
  2. Low (micro)doses of 2,5-dimethoxy-4-propylamphetamine (DOPR) increase effortful motivation in low-performing mice. PubMed / Neuropharmacology (2025). https://doi.org/10.1016/j.neuropharm.2025.110334123
  3. PiHKAL, entry #71: DOPR. Erowid (1991). https://www.erowid.org/library/books_online/pihkal/pihkal071.shtml12
  4. The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects. Molecular Psychiatry / German National Library (2025). https://doi.org/10.1038/s41380-025-03325-11234
  5. Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors. Frontiers in Pharmacology (2023). https://doi.org/10.3389/fphar.2023.11012901
  6. Psychotomimetic Phenylisopropylamines. Journal of Medicinal Chemistry (1975). https://www.erowid.org/archive/rhodium/pdf/shulgin/shulgin.4-alkyl-25-dma.pdf1
  7. PiHKAL: A Chemical Love Story. Transform Press (1991). https://www.thevespiary.org/library/Files_Uploaded_by_Users/llamabox/PiHKAL.pdf1234

Article Status

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