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Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
ModerateClassified as habit-forming. As a stimulant with dopamine and norepinephrine reuptake inhibition, it carries potential for compulsive use patterns typical of this drug class.
Toxicity
No deaths have been reported so far. Overdoses have led to hospital visits with prolonged stimulation and psychological effects persisting for over 24 hours.
Acute cardiovascular effects including tachycardia, hypertension, and chest pain suggestive of possible cardiovascular toxicity have been reported following recreational use; serious cardiac events appear associated with higher doses or combination use.
In vitro studies suggest D2PM may be more neurotoxic than MDMA or MDA at the cellular level, inhibiting normal neurite outgrowth; clinical significance in humans at recreational doses is not established.
Psychosis Risk
Paranoia and visual hallucinations have been reported in multiple case reports, particularly at higher doses or in overdose situations. Psychological symptoms including paranoia and anxiety may persist for 48-96 hours post-administration.
History & Culture
Legality
By Country
United StatesUncontrolledReferences
Source Pages
Further Reading
ACMD advice on diphenyl-2-pyrrolidinyl-methanol (D2PM)
Cardiovascular toxicity from recreational D2PM use. J Med Toxicol 2008
Corkery JM et al. 2-DPMP and D2PM: A preliminary review. Prog Neuropsychopharmacol Biol Psychiatry 2012
Corkery JM et al. Preliminary review of D2PM and 2-DPMP. Prog Neuro-Psychopharmacol 2012
Drugs-Forum: D2PM experiences thread- Meltzer SC et al. Receptor binding profile of diphenylprolinol. J Psychopharmacol 2010
ScienceDirect: Topics – user dose reports (20-50 mg oral, 5-10 h duration)- Wood DM & Dargan PI. Acute toxicity of D2PM and 2-DPMP. Clin Toxicol 2012
- Wood DM et al. Cardiovascular toxicity from D2PM use. J Med Toxicol 2008
- Wood DM et al. Use and acute toxicity of D2PM and 2-DPMP. Clin Toxicol 2012
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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