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Cyclizine

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Cyclizine molecule structureCyclizine molecule structure
Chemical Class
Piperazine

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Moderate25-50 mg

The dosages listed reflect those established for therapeutic applications.

Duration

Onset10-30 minutes
After Effects14 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Low

Some recreational use has been documented, particularly in combination with methadone to produce psychoactive effects, and for its anticholinergic hallucinogenic properties. However, the experience is reported to be uncomfortable and not enjoyable at high dosages.

Toxicity

Hepatic

Rare liver dysfunction has been reported; liver disease may exacerbate sedative effects, warranting caution in patients with pre-existing hepatic conditions.

Cardiovascular

Tachycardia and low blood pressure may occur as antimuscarinic effects, typically at higher doses or in susceptible individuals.

Urinary System

Urinary retention may occur as an antimuscarinic effect, particularly in patients with prostatic hypertrophy or pre-existing urinary conditions.

Central Nervous System

CNS effects including drowsiness, psychomotor impairment, confusion, depression, sleep disturbances, and tremor have been reported; extrapyramidal effects occur rarely.

Ocular

Visual disturbances including blurred vision and diplopia may occur as antimuscarinic effects; use is contraindicated in angle-closure glaucoma.

Psychosis Risk

At high dosages, cyclizine typically induces delirium and vivid realistic hallucinations due to its anticholinergic properties. Hallucinations are listed as a rare adverse effect at therapeutic doses. Confusion has also been reported rarely.

History & Culture

History & Culture not written up yet

Legality

International

Over the counter in many countries.

By Country

Legal / decriminalized2
United States flagUnited StatesLegal (regulated)
Singapore flagSingaporeLegal (regulated)

References

Citations

  1. Cyclizine | National Drug Formulary. ndf.gov.sg (n.d.). https://www.ndf.gov.sg/about-drugs/active-ingredient/m01281/1
  2. NAUSICALM TABLET 50MG (PHARMACY ONLY) [SIN15353P] | National Drug Formulary. ndf.gov.sg (n.d.). https://www.ndf.gov.sg/about-drugs/product-information/sin15353p/1
  3. Reclassification process | Health Sciences Authority. hsa.gov.sg (n.d.). https://www.hsa.gov.sg/therapeutic-products/registration-of-therapeutic-products/variation-application/reclassification/apply-for-reclassification/1
  4. Health Products (Therapeutic Products) Regulations 2016 - Singapore Statutes Online. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/SL/HPA2007-S329-2016?ProvIds=P13-P4_11-1
  5. NAUSICALM TABLET 50MG [SIN15193P] | National Drug Formulary. ndf.gov.sg (n.d.). https://www.ndf.gov.sg/about-drugs/product-information/sin15193p/1
  6. Antiemetic Drug Products for Over-the-Counter Human Use; Final Monograph, 52 FR 15886. archives.federalregister.gov (n.d.). https://archives.federalregister.gov/issue_slice/1987/4/30/15882-15893.pdf1
  7. 21 U.S.C. § 355h — Regulation of certain nonprescription drugs that are marketed without an approved drug application. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?edition=prelim&num=0&req=granuleid%3AUSC-prelim-title21-section355h1
  8. Rulemaking History for OTC Antiemetic Drug Products. fda.gov (n.d.). https://www.fda.gov/drugs/historical-status-otc-rulemakings/rulemaking-history-otc-antiemetic-drug-products1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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