2-Chloroephenidine
2-Chloroephenidine is a dissociative research chemical of the diarylethylamine class and a structural analogue of ephenidine. Very little is known about this compound's pharmacology, toxicity, or subjective effect profile.1 It is believed to produce dissociative effects and is reported to be slightly less potent than its parent compound. Due to the near-total absence of research or documented human use, it should be approached with extreme caution.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Very little is documented about this compound. As a structural analogue of ephenidine, it is considered likely to produce dissociative effects, with slightly lower potency than the parent compound.
Reagent Testing
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Pharmacology
Pharmacodynamics
Pharmacokinetics
Tolerance
Dissociatives, NMDA receptor antagonists
Harm Potential
History & Culture
Legality
References
Source Pages
Citations
Further Reading
Enantiomeric separation of diphenidine derivatives (J Chromatogr B 2025)
French Addictovigilance Network – phenidine complications (2019)
Journal of Psychopharmacology - Pharmacological investigations of diphenidine analogues (2016)
NCATS Inxight entry – 2-Chloro-ephenidine
Nervewing: Diarylethylamines overview (2020)
Pharmacological investigations of diphenidine analogues (J Psychopharmacol 2016)- PLOS ONE - Pharmacological Investigations of Dissociative 'Legal Highs' (2016)
- PubChem: 2 Chloro ephenidine
- PubChem: CID 43489092 - 2-Chloro-ephenidine
- Receptor-binding heat-map of diarylethylamines (2016)
Reddit: r/researchchemicals binding-affinity thread (2023)- Structure–activity summary of diarylethylamines (ResearchGate 2024)
UK ACMD - Diphenidine diarylethylamine review (2023)- UK ACMD diarylethylamine report (2023)
Wiley NPS laboratory testing review (2023)
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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