Allylescaline
Allylescaline is a psychedelic substance in the phenethylamine and scaline classes, and is structurally related to mescaline and escaline. Otakar Leminger reported the compound in 1972,1 and Alexander Shulgin later discussed it in his 1991 book PiHKAL.citation needed It appeared as a novel designer drug in 2013. Allylescaline remains relatively uncommon, with little documented history of human use.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
In a 2025 in-vitro receptor screen, Allylescaline (allylmescaline) showed measurable binding at 5-HT1E, 5-HT2A, 5-HT2B and 5-HT2C. Binding was strongest at 5-HT2B among these measured targets. These affinity measurements do not by themselves establish partial- or full-agonist efficacy, human receptor occupancy, clinical potency or safety. [S1][S2]
Pharmacokinetics
There have been no studies on the pharmacokinetic profile of allylescaline and the metabolism of allylescaline is unknown.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowAllylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Physical
Extremely LowNo evidence of physical dependence. The substance is described as not habit-forming.
History & Culture
Allylescaline was first documented in the scientific literature by Czech chemist Otakar Leminger in 1972.citation needed The compound received broader attention when American chemist Alexander Shulgin synthesized and characterized its psychoactive effects, publishing his findings in the 1991 book…
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Legality
By Country
References
Source Pages
Citations
- Otakar Leminger. (1972). Příspěvek k chemii v jádře alkoxylovaných β-fenoetylaminů – II: O některých v jádře alkoxylovaných β-fenoetylaminech, resp. jejich sulfátech. Chemický Průmysl, 22, 553–557. https://isomerdesign.com/bitnest/external/ChemickyPrumysl/22.5531
- Anlage I BtMG (nicht verkehrsfähige Betäubungsmittel). gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html1
- 薬物乱用防止に関する情報 — Ministry of Health, Labour and Welfare. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/index.html1
- 指定薬物名称・構造式一覧 (current as of 27 August 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743040.pdf1
- 指定薬物一覧 (current as of 27 August 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743041.xlsx1
- 平成27年3月25日付けで以下の16物質が指定薬物に指定されました — MHLW. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/20150130-2.html1
- 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律 (PMD Act). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/web/t_doc?dataId=81004000&dataType=01
- About the Penalties for Drug Offenses in Japan — Designated Substances. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001682850.pdf1
- 麻薬及び向精神薬取締法 別表第1 (MHLW narcotics schedule). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001685509.pdf1
- 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令 第1条. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001733550.pdf1
Further Reading
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
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Recent changes8 human edits · latest
Times are UTCNewest first
31 July 2026
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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