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Allylescaline

Allylescaline molecule structureAllylescaline molecule structure
4-Allyloxy-3,5-dimethoxyphenethylamine
AL, Allylmescaline
Psychoactive Class

Allylescaline is a psychedelic substance in the phenethylamine and scaline classes, and is structurally related to mescaline and escaline. Otakar Leminger reported the compound in 1972,1 and Alexander Shulgin later discussed it in his 1991 book PiHKAL.citation needed It appeared as a novel designer drug in 2013. Allylescaline remains relatively uncommon, with little documented history of human use.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~15 mg
Light20-30 mg
Moderate30-40 mg
Strong40-60 mg
Heavy60+ mg

Duration

Onset45-240 minutes
Peak60-75 minutes
After Effects1-16 hours
Total8-12 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Forked from Subjective Effect Documentation work byJosie Kins August 2016.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → red2
Mecke(ME)
white → yellow2 → brown2 → brown3
Mandelin(MD)
yellow2 → brown2 → brown3
Liebermann(LB)
white → brown2 → black3
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

In a 2025 in-vitro receptor screen, Allylescaline (allylmescaline) showed measurable binding at 5-HT1E, 5-HT2A, 5-HT2B and 5-HT2C. Binding was strongest at 5-HT2B among these measured targets. These affinity measurements do not by themselves establish partial- or full-agonist efficacy, human receptor occupancy, clinical potency or safety. [S1][S2]

Pharmacokinetics

There have been no studies on the pharmacokinetic profile of allylescaline and the metabolism of allylescaline is unknown.

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Develops almost immediately after ingestion.
Baseline Reset
7 days
Half Tolerance
Approximately 3 days
Cross Tolerance

Psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Allylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.

Physical

Extremely Low

No evidence of physical dependence. The substance is described as not habit-forming.

History & Culture

Allylescaline was first documented in the scientific literature by Czech chemist Otakar Leminger in 1972.citation needed The compound received broader attention when American chemist Alexander Shulgin synthesized and characterized its psychoactive effects, publishing his findings in the 1991 book

Trip Reports

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Legality

By Country

Illegal4
Germany flagGermanyIllegal
Japan flagJapanIllegal
Sweden flagSwedenIllegal
United Kingdom flagUnited KingdomIllegal (Psychoactive Substances Act)
Controlled / restricted2
United States flagUnited StatesRestricted
Switzerland flagSwitzerlandRestricted

References

Source Pages

  1. Bluelight: The Big & Dandy Allylescaline Thread
  2. Erowid: Allylescaline Vault
  3. Isomer Design - PiHKAL Entry #2: AL
  4. Isomer Design (TiHKAL/PiHKAL)
  5. PsychonautWiki
  6. Shulgin, A.; Shulgin, A. (1991). PiHKAL: A Chemical Love Story, Entry #2
  7. TripSit Factsheets
  8. Wikipedia

Citations

  1. Otakar Leminger. (1972). Příspěvek k chemii v jádře alkoxylovaných β-fenoetylaminů – II: O některých v jádře alkoxylovaných β-fenoetylaminech, resp. jejich sulfátech. Chemický Průmysl, 22, 553–557. https://isomerdesign.com/bitnest/external/ChemickyPrumysl/22.5531
  2. Anlage I BtMG (nicht verkehrsfähige Betäubungsmittel). gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html1
  3. 薬物乱用防止に関する情報 — Ministry of Health, Labour and Welfare. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/index.html1
  4. 指定薬物名称・構造式一覧 (current as of 27 August 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743040.pdf1
  5. 指定薬物一覧 (current as of 27 August 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743041.xlsx1
  6. 平成27年3月25日付けで以下の16物質が指定薬物に指定されました — MHLW. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/20150130-2.html1
  7. 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律 (PMD Act). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/web/t_doc?dataId=81004000&dataType=01
  8. About the Penalties for Drug Offenses in Japan — Designated Substances. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001682850.pdf1
  9. 麻薬及び向精神薬取締法 別表第1 (MHLW narcotics schedule). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001685509.pdf1
  10. 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令 第1条. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001733550.pdf1

Further Reading

  1. Kolaczynska et al. (2022). Receptor interaction profiles of mescaline derivatives

Article Status

  • Josie Kins avatar
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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

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31 July 2026

  1. Lyrea · Updated the article

  2. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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