ALEPH
ALEPH is a psychedelic amphetamine of the substituted phenethylamine class, notable for being the first sulfur-containing phenethylamine evaluated for central nervous system activity as a stimulant or psychedelic.1 Its full chemical name is 2,5-dimethoxy-4-methylthioamphetamine.12 The substance remains relatively unexplored compared to its higher homologues in the ALEPH series, a group named after the first letter of the Hebrew alphabet due to their potentially extraordinary shared properties.1
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Aleph is best characterized by the erratic and unpredictable nature of its response curve: the same dose can produce a profound peak experience in one instance and only mild, unremarkable effects in another, even in experienced users. Reported experiences range from an uneventful threshold state at moderate doses to full-intensity psychedelic intoxication, with one landmark low-dose experience marked by ego-inflation and mania-like thought processes that could not be reproduced on subsequent attempts.
Cognitive
The headspace at full intensity involves a rapid and disorienting shift in frame of reference. Verbal and social faculties can remain largely intact — conversation by telephone stays manageable — while mechanical and sequential tasks such as reading, arranging objects, or alphabetizing become alien and effectively impossible, and driving is entirely out of the question. Peak experiences have featured pronounced ego-inflation with elements resembling mania.
Reagent Testing
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Pharmacology
Pharmacodynamics
ALEPH (2,5-dimethoxy-4-methylthioamphetamine) is a sulfur-containing psychedelic amphetamine.3 Its specific receptor-level pharmacology has not been characterized in the provided literature.
Pharmacokinetics
Tolerance
Serotonergic psychedelics, Other 5-HT2A agonists
Harm Potential
Toxicity
Qualitative reports describe impaired task performance, altered frame of reference, ego-inflation, and mania-like thought processes.
Psychosis Risk
The extracted commentary mentions ego-inflation and mania-like thought processes during psychedelic intoxication1, but does not report psychosis.
History & Culture
ALEPH holds a notable place in psychedelic chemistry as the first sulfur-containing phenethylamine to be evaluated for central nervous system activity, specifically for its potential stimulant or psychedelic properties.1 This pioneering incorporation of a methylthio group…
Legality
References
Source Pages
Citations
- Alexander Shulgin, & Ann Shulgin. (1991). PiHKAL: A Chemical Love Story — #3 ALEPH. Transform Press. https://erowid.org/library/books_online/pihkal/pihkal003.shtml123456789
- David E. Nichols, & Alexander T. Shulgin. (1976). Sulfur analogs of psychotomimetic amines. Journal of Pharmaceutical Sciences, 65(10), 1554–1556. https://doi.org/10.1002/jps.26006510401
- Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, & Liechti ME. (January 2023). Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines. Psychopharmacology, 240(1), 115-126. https://doi.org/10.1007/s00213-022-06279-21
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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