Skip to main content
Lyrea avatar

Not yet reviewed — this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

5-IT

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Legality
5-IT molecule structure5-IT molecule structure
Chemical Class
Indole

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~50 mg
Light50 mg
Moderate50-100 mg
Strong100-150 mg
Heavy150+ mg

Duration

Onset1.5-2 hours
After Effects1-48 hours
Total8-12 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → red2
Mecke(ME)
white → brown2
Mandelin(MD)
yellow2 → brown2
Liebermann(LB)
white → brown3
Powered by PROtestkit.eu

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming. The stimulant and empathogenic properties may contribute to psychological reinforcement and compulsive use patterns.

Toxicity

Lethal Dosage

5-IT has been attributed to 14 deaths in Sweden between April and July 2012, all in young men aged 20-30. While 5-IT was the sole intoxicant in two cases, other drugs were present in the remaining twelve. Eleven non-fatal poisonings also occurred during the same period.

Cardiovascular

Acute cardiovascular effects including tachycardia and increased blood pressure occur during intoxication; these effects were noted even at relatively low doses of 20mg.

Thermoregulatory

The drug is prone to cause overheating and hyperthermia, which has been identified as a significant toxicity concern and may have contributed to reported fatalities.

Psychosis Risk

Moderate

Visual and auditory hallucinations, disorientation, agitation, restlessness, and anxiety have been reported. Aggressiveness and moodiness are also noted as negative effects.

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the 5-IT article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.