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3-MeO-PCPy

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Subjective Effects
Interactions
Tolerance
3-MeO-PCPy molecule structure3-MeO-PCPy molecule structure
Psychoactive Class
Chemical Class

3-MeO-PCPy is a dissociative research chemical and the 3-methoxy analogue of rolicyclidine (PCPy).citation needed Structurally related to phencyclidine (PCP), it is reported to produce less pronounced opioid-like effects than PCP, though such effects remain notable. Very limited information is available regarding its pharmacology, toxicity, or safe dosage ranges. It is considered habit-forming, and extreme caution is advised due to the scarcity of available data.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~1 mg
Light1-3 mg
Moderate3-6 mg
Strong6-10 mg
Heavy10+ mg

Duration

Onset5-20 minutes
Total2-4 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

3-MeO-PCPy is the 3-methoxy analogue of rolicyclidine (PCPy).1 It reportedly exhibits opioid-like activity that is less pronounced than that of phencyclidine (PCP) but still notable. Detailed receptor-level characterization remains limited.

Pharmacokinetics

A study using rat urine and pooled human liver microsomes identified 3-MeO-PCPy pathways including aliphatic hydroxylation of the cyclohexyl and pyrrolidine rings, aromatic hydroxylation, carboxylation after ring opening, O-demethylation, and glucuronidation.2 In expressed-enzyme incubations, CYP2B6 catalyzed aliphatic hydroxylation, while CYP2C9 and CYP2D6 catalyzed O-demethylation.2 The detailed in-vivo metabolite profile came from rats, and the human findings were produced in vitro; clinical data are needed before inferring human pharmacokinetic variability or whole-body parameters.citation needed

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Classified as habit-forming by community harm reduction resources, suggesting some potential for compulsive use patterns.

History & Culture

3-MeO-PCPy is a 3-methoxy analogue of rolicyclidine (PCPy),1 belonging to the arylcyclohexylamine class of dissociative compounds. It represents one of several structural modifications explored within this chemical class, which also includes the related compound phencyclidine (PCP).1 Detailed documentation regarding its specific synthesis history, original development, and cultural significance remains limited in available literature.

Legality

International

As of 23 August 2026, 3-MeO-PCPy (3-methoxyrolicyclidine) is not named or chemically designated in the current complete INCB Yellow, Green or Red Lists. The Green List instead places unmodified rolicyclidine (PHP/PCPy; 1-(1-phenylcyclohexyl)pyrrolidine) in Schedule I and separately places 3-methoxyphencyclidine (1-(1-(3-methoxyphenyl)cyclohexyl)piperidine) in Schedule II. Those entries do not cover the target: the former lacks the 3-methoxy substitution and the latter has a piperidine ring rather than PCPy's pyrrolidine ring. INCB's March 2026 notice adds only MDMB-FUBINACA to Schedule II, with effect from 25 November 2026, and does not name 3-MeO-PCPy. Accordingly, the current INCB materials establish no scheduling of 3-MeO-PCPy under the 1961, 1971 or 1988 conventions.

By Country

Illegal18
United States flagUnited StatesIllegal (analog/blanket ban)
Argentina flagArgentinaIllegal (analog/blanket ban)
Australia flagAustraliaIllegal (analog/blanket ban)
Austria flagAustriaIllegal (analog/blanket ban)
Canada flagCanadaIllegal (analog/blanket ban)
China flagChinaIllegal
Germany flagGermanyIllegal (analog/blanket ban)
Ireland flagIrelandIllegal (analog/blanket ban)
Israel flagIsraelIllegal (analog/blanket ban)
New Zealand flagNew ZealandIllegal (analog/blanket ban)
Poland flagPolandIllegal (analog/blanket ban)
Russia flagRussiaIllegal (analog/blanket ban)
Singapore flagSingaporeIllegal (analog/blanket ban)
South Africa flagSouth AfricaIllegal (analog/blanket ban)
South Korea flagSouth KoreaIllegal (analog/blanket ban)
Switzerland flagSwitzerlandIllegal (analog/blanket ban)
Ukraine flagUkraineIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)
Controlled / restricted1
Mexico flagMexicoRestricted

References

Citations

  1. Michely, J.A., Manier, S.K., Caspar, A.T., Brandt, S.D., Wallach, J., & Maurer, H.H.. (2017). New Psychoactive Substances 3-Methoxyphencyclidine (3-MeO-PCP) and 3-Methoxyrolicyclidine (3-MeO-PCPy): Metabolic Fate Elucidated with Rat Urine and Human Liver Preparations and their Detectability in Urine by GC-MS, LC-(High Resolution)-MSn and LC-(High Resolution)-MS/MS. pmc.ncbi.nlm.nih.gov, 15(5), 692–718. https://doi.org/10.2174/1570159x1466616103111373112345
  2. Julian A. Michely, Sascha K. Manier, Achim T. Caspar, Simon D. Brandt, Jason Wallach, & Hans H. Maurer. (2017). New Psychoactive Substances 3-Methoxyphencyclidine (3-MeO-PCP) and 3-Methoxyrolicyclidine (3-MeO-PCPy): Metabolic Fate Elucidated with Rat Urine and Human Liver Preparations and their Detectability in Urine by GC-MS, LC-(High Resolution)-MSn and LC-(High Resolution)-MS/MS. 15(5), 692-712. https://doi.org/10.2174/1570159x1466616101815171612
  3. Decreto 560/2019, artículo 2 y Anexo II (Grupo 2: Arilciclohexilaminas). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
  4. Decreto 560/2019, artículo 2 y Anexo II (Grupo 2: Arilciclohexilaminas). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/326675_dec560-2_pdf/archivo1
  5. Decreto 560/2019, artículo 2 y Anexo II (Grupo 2: Arilciclohexilaminas). boletinoficial.gob.ar (n.d.). https://www.boletinoficial.gob.ar/detalleAviso/primera/213527/201908151
  6. Criminal Code Act 1995, ss 301.1, 301.4 and 301.9; Criminal Code Regulations 2019, ss 11 and 14, Schedule 1 cl 1 item 221 and Schedule 2 cl 1 item 181. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_2/document_2.html1
  7. Criminal Code Act 1995, ss 301.1, 301.4 and 301.9; Criminal Code Regulations 2019, ss 11 and 14, Schedule 1 cl 1 item 221 and Schedule 2 cl 1 item 181. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-12-13/2025-12-13/text/original/epub/OEBPS/document_1/document_1.html1
  8. Neue-Psychoaktive-Substanzen-Verordnung, Annex II group 8; Neue-Psychoaktive-Substanzen-Gesetz, section 4. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
  9. Neue-Psychoaktive-Substanzen-Verordnung, Annex II group 8; Neue-Psychoaktive-Substanzen-Gesetz, section 4. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/eli/bgbl/i/2011/146/P4/NOR401344471
  10. Controlled Drugs and Substances Act, Schedule I, item 14. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/FullText.html1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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