3-MeO-PCPy
3-MeO-PCPy is a dissociative research chemical and the 3-methoxy analogue of rolicyclidine (PCPy).1 Structurally related to phencyclidine (PCP), it is reported to produce less pronounced opioid-like effects than PCP, though such effects remain notable. Very limited information is available regarding its pharmacology, toxicity, or safe dosage ranges. It is considered habit-forming, and extreme caution is advised due to the scarcity of available data.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
3-MeO-PCPy is the 3-methoxy analogue of rolicyclidine (PCPy).2 It reportedly exhibits opioid-like activity that is less pronounced than that of phencyclidine (PCP) but still notable. Detailed receptor-level characterization remains limited.
Pharmacokinetics
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming by community harm reduction resources, suggesting some potential for compulsive use patterns.
History & Culture
3-MeO-PCPy is a 3-methoxy analogue of rolicyclidine (PCPy),2 belonging to the arylcyclohexylamine class of dissociative compounds. It represents one of several structural modifications explored within this chemical class, which also includes the related compound phencyclidine (PCP).2 Detailed documentation regarding its specific synthesis history, original development, and cultural significance remains limited in available literature.
Legality
References
Citations
- Julian A. Michely, Sascha K. Manier, Achim T. Caspar, Simon D. Brandt, Jason Wallach, & Hans H. Maurer. (2017). New Psychoactive Substances 3-Methoxyphencyclidine (3-MeO-PCP) and 3-Methoxyrolicyclidine (3-MeO-PCPy): Metabolic Fate Elucidated with Rat Urine and Human Liver Preparations and their Detectability in Urine by GC-MS, LC-(High Resolution)-MSn and LC-(High Resolution)-MS/MS. 15(5), 692-712. https://doi.org/10.2174/1570159x146661610181517161
- Michely, J.A., Manier, S.K., Caspar, A.T., Brandt, S.D., Wallach, J., & Maurer, H.H.. (2017). New Psychoactive Substances 3-Methoxyphencyclidine (3-MeO-PCP) and 3-Methoxyrolicyclidine (3-MeO-PCPy): Metabolic Fate Elucidated with Rat Urine and Human Liver Preparations and their Detectability in Urine by GC-MS, LC-(High Resolution)-MSn and LC-(High Resolution)-MS/MS. 15(5), 692–718. https://doi.org/10.2174/1570159x14666161031113731123
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the 3-MeO-PCPy article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.