3-Cl-PCP
3-Cl-PCP is a novel dissociative substance of the arylcyclohexylamine class that produces dissociative, hallucinogenic, and euphoric effects.12 First identified in Slovenia in December 2020, it emerged alongside other novel dissociatives such as 3-F-PCP and DMXE.1 It exhibits comparable potency to phencyclidine with a slightly distinct pharmacological profile, being somewhat more potent as an NMDA antagonist.1 Its effects include dose-dependent dissociative anesthesia.2
Contents
Dosage & Duration
Subjective Effects
3-Cl-PCP produces a dissociative experience broadly comparable to phencyclidine, with a potency in the same range as its parent compound. As with other PCP-type arylcyclohexylamines, the experience centers on a progressive sense of detachment from the body and surroundings, though its precise effects profile is reported to differ somewhat from PCP itself. Detailed subjective documentation of this compound remains limited.
Physical
Physical effects follow the dissociative pattern of diminishing bodily awareness and connection at higher doses.
Cognitive
The headspace is dissociative in character, marked by a growing sense of detachment from thought and environment as the dose increases.
Reagent Testing
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Pharmacology
Pharmacodynamics
3-Cl-PCP acts principally as an NMDA receptor antagonist. Compared to PCP, it is somewhat more potent at the NMDA receptor while retaining comparable potency as a dopamine reuptake inhibitor.1
Pharmacokinetics
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Tolerance
Dissociatives
Harm Potential
Addiction & Dependence
Psychological
ModerateEarly reports suggest 3-Cl-PCP is likely moderately addictive with habit-forming properties that may exceed those of other dissociatives such as ketamine, MXE, and DCK. Compulsive redosing is reported, particularly via smoked or vaporized routes of administration.2
Physical
Cravings and withdrawal effects may occur upon cessation after chronic use, though specific physical withdrawal symptoms have not been characterized.
Toxicity
Reports suggest 3-Cl-PCP produces cardiovascular effects including abnormal heartbeat, elevated blood pressure, and increased heart rate during intoxication, with sensations of cardiovascular strain as if the body is working harder to metabolize the substance; these effects appear more prominent than with related dissociatives.
Respiratory depression has been reported as a physical effect and may present increased risk at higher doses.
Repeated and excessive use over extended periods may cause bladder and urinary tract problems similar to ketamine-induced cystitis, though likely to a lesser extent due to the higher potency requiring smaller amounts of substance to be consumed.
Psychosis Risk
Reports suggest a high potential for adverse psychological effects including psychosis and delusions. Risk appears elevated with chronic use or at higher doses.2
Seizure Risk
Seizures may occur in individuals predisposed to them, especially in physically taxing conditions such as dehydration, fatigue, or malnourishment. The extent to which seizures occur at typical doses remains unknown.
History & Culture
3-Cl-PCP is a novel dissociative from the arylcyclohexylamine class that emerged as part of a wave of designer drugs in the early 2020s. It was first identified in Slovenia in December 2020, marking its initial appearance on the recreational drug market.…
Legality
By Country
References
Source Pages
Citations
- (2020). Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.6324051234
- (Jun 2024). Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents. J Pharmacol Exp Ther, 390(1), 14–28. https://doi.org/10.1124/jpet.123.0019421234
- (n.d.). Neue-psychoaktive-Stoffe-Gesetz (NpSG) — Anlage 1, Stoffgruppe 6: Von Arylcyclohexyl(methyl)amin abgeleitete Verbindungen. https://www.gesetze-im-internet.de/npsg/anlage_1.html1
- (n.d.). Neue-psychoaktive-Stoffe-Gesetz (NpSG) — § 3 Unerlaubter Umgang mit neuen psychoaktiven Stoffen. https://www.gesetze-im-internet.de/npsg/__3.html1
- (n.d.). Psychoactive Substances Act 2016, Section 2 — Meaning of 'psychoactive substance'. https://www.legislation.gov.uk/ukpga/2016/2/section/21
- (n.d.). Psychoactive Substances Act 2016, Section 4 — Producing a psychoactive substance. https://www.legislation.gov.uk/ukpga/2016/2/section/41
- (n.d.). Psychoactive Substances Act 2016, Section 5 — Supplying, or offering to supply, a psychoactive substance. https://www.legislation.gov.uk/ukpga/2016/2/section/51
- (n.d.). Psychoactive Substances Act 2016, Section 8 — Importing or exporting a psychoactive substance. https://www.legislation.gov.uk/ukpga/2016/2/section/81
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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