Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
HighDiscrimination studies have found 3,4-CTMP to be more addictive than cocaine. Reports compare its abuse potential to amphetamine or MDMA, citing limited tolerance, euphoric effects, and dopamine-transporter activity.
Toxicity
Chronic use or high doses may cause serious cardiovascular effects including pulmonary hypertension, heart valve fibrosis, abnormal heartbeat, and severe vasoconstriction; these risks are particularly concerning due to the substance's potent 5-HT2B receptor agonism.
5-HT2B receptor agonism may contribute to pulmonary hypertension, which can present with breathing difficulty, lightheadedness, and related cardiovascular warning signs. This hazard may become severe or fatal, particularly with high doses or long-term use.
Insufflation is reported to be painful and potentially extremely caustic due to low water solubility preventing ready absorption through nasal mucus membranes.
Psychosis Risk
Prolonged misuse can result in stimulant psychosis, especially when excessive dosing is combined with sleep deprivation.
History & Culture
Legality
By Country
References
Citations
- Controlled Drugs and Substances Act — current consolidated Schedule III. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95602.html1
- Order Amending Schedule III to the Controlled Drugs and Substances Act (Methylphenidate), SOR/2017-44. gazette.gc.ca (n.d.). https://gazette.gc.ca/rp-pr/p2/2017/2017-04-05/html/sor-dors44-eng.html1
- Controlled Drugs and Substances Act, section 4 — Possession of substance. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-4.html1
- Controlled Drugs and Substances Act, section 5 — Trafficking in substance. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-5.html1
- Controlled Drugs and Substances Act, section 6 — Importing and exporting. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-6.html1
- Controlled Drugs and Substances Act, section 7 — Production of substance. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-7.html1
- 我国管制毒品目录(2026年7月更新,540种+三大类). ga.sz.gov.cn (n.d.). https://ga.sz.gov.cn/SZJDZX/SZBMFW/content/post_12898420.html1
- 三部门联合发布最新版《非药用类麻醉药品和精神药品目录》. btgaj.xjbt.gov.cn (n.d.). https://btgaj.xjbt.gov.cn/c/2025-07-28/8428464.shtml1
- 麻醉药品和精神药品管理条例. amr.hainan.gov.cn (n.d.). https://amr.hainan.gov.cn/himpa/xxgk/zcfg/ypl/202503/t20250324_3837790.html1
- 非药用类麻醉药品和精神药品列管办法. gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the 3-4-CTMP article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.