Not yet reviewed — this article is pending editorial review by Lyrea.

25I-NBMD

2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2,3-methylenedioxybenzyl)ethanamine

NBMD-2C-I, Cimbi-29

Psychoactive Class

Psychedelic Hallucinogen

Chemical Class

Phenethylamine (N-benzylated)

25I-NBMD is a synthetic psychedelic of the substituted phenethylamine class, specifically an N-benzylated derivative of 2C-I.¹ It was discovered in 2006 by a research team led by David Nichols at Purdue University. Closely related to the 25X-NBOMe series, it is a highly potent compound that acts as a partial agonist at the 5-HT2A receptor.¹ As a research chemical, it has very limited documentation regarding its effects and safety profile in humans.

Dosage & Duration

Dosage

Threshold~800 µg

Light800-1500 µg

Moderate1500-2000 µg

Strong2000-3000 µg

Heavy3000+ µg

Duration

Onset20-40 minutes

After Effects1-8 hours

Total4-6 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)

Mecke(ME)

Mandelin(MD)

Liebermann(LB)

PROtestkit.eu

Pharmacology

Pharmacodynamics

25I-NBMD acts as a potent partial agonist at the serotonin 5-HT2A receptor, with a reported Ki of 0.049 nM at the human 5-HT2A receptor. It is a derivative of the phenethylamine hallucinogen 2C-I, featuring an N-benzyl substitution with a methylenedioxy group.¹

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check

TripSit

Tolerance

Cross Tolerance

Serotonergic psychedelics, 5-HT2A agonists

Harm Potential

Toxicity

Lethal Dosage

No lethal-dose or LD50 data were identified. Avoiding other psychedelics, stimulants, and redosing is advised.

History & Culture

25I-NBMD was discovered in 2006 by a research team at Purdue University led by David Nichols.² The compound is a derivative of the phenethylamine hallucinogen 2C-I, developed as part of ongoing investigations into serotonin receptor…

Legality

International

The complete current official Yellow, Green, and Red Lists contain no listing for 25I-NBMD, NBMD-2C-I, or Cimbi-29. The Green List separately lists 25I-NBOMe in Schedule I as 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine; that distinct listing does not establish international scheduling of 25I-NBMD.

By Country

CanadaIllegalSchedule III

Controlled Drugs and Substances Act, Schedule III, item 35³⁴

25I-NBMD falls within the Act’s Schedule III class for 2C-phenethylamines. Item 35 covers the specified phenethylamine structure when the amino group is substituted by benzyl groups substituted to any extent; 25I-NBMD’s N-(methylenedioxybenzyl) substitution is within that description. Possession is prohibited unless authorized under the regulations.

GermanyIllegal (analog/blanket ban)Phenethylamine derivative

Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1 und § 3⁷⁸

25I-NBMD is covered as a derivative of 2-phenethylamine under Anlage 1 Nr. 1 NpSG. Its 2-(4-iodo-2,5-dimethoxyphenyl)ethylamine core fits the listed phenyl ring and permitted iodine and alkoxy substitutions, while its N-(benzodioxolylmethyl) substituent fits the permitted benzyl substitution at nitrogen; § 3 prohibits possession, acquisition, manufacture, trade, supply, and import or export of such Anlage 1 substances, subject to the statutory exceptions.

PolandIllegalI-P

Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz.U. 2024 poz. 1139, zmieniony Dz.U. 2025 poz. 598 i Dz.U. 2026 poz. 934)^11121314

The official ELI metadata identifies Dz.U. 2024 poz. 1139 as IN_FORCE and lists the two post-consolidation amendments. Dz.U. 2025 poz. 598 repeals I-P row 7 only; Dz.U. 2026 poz. 934 revises I-P row 96 and repeals row 99 only. Neither amendment affects I-P row 17. Under art. 33(2) of the Act on Counteracting Drug Addiction, I-P psychotropic substances may be used exclusively for research; unauthorized possession of a psychotropic substance is criminalized by art. 62(1). This supports the canonical mapping to prohibited, while recognizing the statutory research-only exception.

UkraineIllegal (analog/blanket ban)Phenethylamine derivative

Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, List of Narcotic Drugs, Psychotropic Substances and Precursors¹⁷

25I-NBMD (NBMD-2C-I; Cimbi-29) is covered as a phenethylamine-group derivative in Table I, List No. 2 of Ukraine's controlled-substances list. That list covers especially dangerous psychotropic substances whose circulation is prohibited. The resolution separately names 25I-NBOMe, but this determination relies on the phenethylamine-derivative provision for 25I-NBMD and does not treat the two compounds as identical.

FinlandIllegalConsumer-market ban

Government Decree on psychoactive substances banned from the consumer market (1130/2014), appendix, consolidated through amendment 650/2026⁵⁶

25I-NBMD is expressly listed in the current consolidated appendix to Decree 1130/2014. The decree's legal effect is a prohibition from the consumer market; this finding does not characterize the substance as a narcotic or state a broader criminal-law status.

NetherlandsIllegal (analog/blanket ban)Lijst IA stofgroep

Opiumwet, lijst IA⁹¹⁰

25I-NBMD valt onder de Lijst IA-stofgroep voor substanties afgeleid van 2-fenethylamine. De officiële definitie omvat een fenylring met onder meer jood- en alkoxy-substituenten en staat benzylsubstitutie op het stikstofatoom toe; de geregistreerde structuur van 25I-NBMD is N-(1,3-benzodioxol-4-ylmethyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethanamine. Artikel 2a verbiedt het binnen of buiten Nederland brengen, bereiden, verkopen, vervoeren, aanwezig hebben en vervaardigen van een substantie die deel uitmaakt van een Lijst IA-stofgroep, behoudens de wettelijke uitzonderingen.

SwedenIllegalFörteckning I

Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika, as amended by LVFS 2014:11¹⁵

Classified under Swedish schedule I, which covers substances without recognized medical use. Added on January 16, 2015, through Medical Products Agency regulation LVFS 2014:11.¹⁶

United KingdomIllegal (analog/blanket ban)Class A

Misuse of Drugs Act 1971, Schedule 2, Part I, paragraph 1(f), inserted by the Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014¹⁸¹⁹

Controlled under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause.²⁰ Class A substances carry the most severe penalties, with possession punishable by up to seven years imprisonment and supply offenses carrying potential life sentences.

References

Source Pages

Citations

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