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25I-NBMD
2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2,3-methylenedioxybenzyl)ethanamine
NBMD-2C-I, Cimbi-29
25I-NBMD is a synthetic psychedelic of the substituted phenethylamine class, specifically an N-benzylated derivative of 2C-I.1 It was discovered in 2006 by a research team led by David Nichols at Purdue University. Closely related to the 25X-NBOMe series, it is a highly potent compound that acts as a partial agonist at the 5-HT2A receptor.citation needed As a research chemical, it has very limited documentation regarding its effects and safety profile in humans.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~800 µg
Light800-1500 µg
Moderate1500-2000 µg
Strong2000-3000 µg
Heavy3000+ µg
Duration
Onset20-40 minutes
After Effects1-8 hours
Total4-6 hours
Subjective Effects
Subjective Effects not written up yet
Pharmacology
Pharmacodynamics
25I-NBMD acts as a potent partial agonist at the serotonin 5-HT2A receptor, with a reported Ki of 0.049 nM at the human 5-HT2A receptor. It is a derivative of the phenethylamine hallucinogen 2C-I, featuring an N-benzyl substitution with a methylenedioxy group.1
Pharmacokinetics
Absorption & half-lifenot documented yetMetabolitesnone documented yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Cross Tolerance
Serotonergic psychedelics, 5-HT2A agonists
Harm Potential
Toxicity
Lethal Dosage
No lethal-dose or LD50 data were identified. Avoiding other psychedelics, stimulants, and redosing is advised.
History & Culture
25I-NBMD was discovered in 2006 by a research team at Purdue University led by David Nichols.citation needed The compound is a derivative of the phenethylamine hallucinogen 2C-I, developed as part of ongoing investigations into serotonin receptor pharmacology.…
Legality
International
The complete current official Yellow, Green, and Red Lists contain no listing for 25I-NBMD, NBMD-2C-I, or Cimbi-29. The Green List separately lists 25I-NBOMe in Schedule I as 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine; that distinct listing does not establish international scheduling of 25I-NBMD.
By Country
Illegal8
CanadaIllegal25I-NBMD falls within the Act’s Schedule III class for 2C-phenethylamines. Item 35 covers the specified phenethylamine structure when the amino group is substituted by benzyl groups substituted to any extent; 25I-NBMD’s N-(methylenedioxybenzyl) substitution is within that description. Possession is prohibited unless authorized under the regulations.
FinlandIllegalGovernment Decree on psychoactive substances banned from the consumer market (1130/2014), appendix, consolidated through amendment 650/202645
25I-NBMD is expressly listed in the current consolidated appendix to Decree 1130/2014. The decree's legal effect is a prohibition from the consumer market; it does not characterize the substance as a narcotic or establish a broader criminal-law status.
GermanyIllegal (analog/blanket ban)25I-NBMD is covered as a derivative of 2-phenethylamine under Anlage 1 Nr. 1 NpSG. Its 2-(4-iodo-2,5-dimethoxyphenyl)ethylamine core fits the listed phenyl ring and permitted iodine and alkoxy substitutions, while its N-(benzodioxolylmethyl) substituent fits the permitted benzyl substitution at nitrogen; § 3 prohibits possession, acquisition, manufacture, trade, supply, and import or export of such Anlage 1 substances, subject to the statutory exceptions.
NetherlandsIllegal (analog/blanket ban)25I-NBMD valt onder de Lijst IA-stofgroep voor substanties afgeleid van 2-fenethylamine. De officiële definitie omvat een fenylring met onder meer jood- en alkoxy-substituenten en staat benzylsubstitutie op het stikstofatoom toe; de geregistreerde structuur van 25I-NBMD is N-(1,3-benzodioxol-4-ylmethyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethanamine. Artikel 2a verbiedt het binnen of buiten Nederland brengen, bereiden, verkopen, vervoeren, aanwezig hebben en vervaardigen van een substantie die deel uitmaakt van een Lijst IA-stofgroep, behoudens de wettelijke uitzonderingen.
PolandIllegalRozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz.U. 2024 poz. 1139, zmieniony Dz.U. 2025 poz. 598 i Dz.U. 2026 poz. 934)10111213
Dz.U. 2024 poz. 1139 is in force and was amended twice after consolidation. Dz.U. 2025 poz. 598 repeals I-P row 7 only; Dz.U. 2026 poz. 934 revises I-P row 96 and repeals row 99 only. Neither amendment affects I-P row 17. Under art. 33(2) of the Act on Counteracting Drug Addiction, I-P psychotropic substances may be used exclusively for research; unauthorized possession of a psychotropic substance is criminalized by art. 62(1). I-P psychotropic substances are prohibited, subject to the statutory research-only exception.
UkraineIllegal (analog/blanket ban)Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, List of Narcotic Drugs, Psychotropic Substances and Precursors16
25I-NBMD (NBMD-2C-I; Cimbi-29) is covered as a phenethylamine-group derivative in Table I, List No. 2 of Ukraine's controlled-substances list. That list covers especially dangerous psychotropic substances whose circulation is prohibited. The resolution separately names 25I-NBOMe; 25I-NBMD is covered by the phenethylamine-derivative provision and is not identical to 25I-NBOMe.
United KingdomIllegal (analog/blanket ban)Misuse of Drugs Act 1971, Schedule 2, Part I, paragraph 1(f), inserted by the Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 20141718
Controlled under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause.19 Class A substances carry the most severe penalties, with possession punishable by up to seven years imprisonment and supply offenses carrying potential life sentences.
References
Source Pages
Citations
- Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response. (n.d.). https://pmc.ncbi.nlm.nih.gov/articles/PMC3866097/12
- Controlled Drugs and Substances Act — Schedule III, item 35. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-10.html1
- Controlled Drugs and Substances Act — section 4. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-1.html1
- Government Decree on psychoactive substances banned from the consumer market (1130/2014), appendix, consolidated through amendment 650/2026. finlex.fi (n.d.). https://finlex.fi/api/media/statute-consolidated/1074839/media/8500.pdf1
- Government Decree on psychoactive substances banned from the consumer market (1130/2014), appendix, consolidated through amendment 650/2026. finlex.fi (n.d.). https://www.finlex.fi/api/media/statute/894482/mainPdf/main.pdf1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1 und § 3. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1 und § 3. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1
- Opiumwet. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/BWBR0001941/1
- PubChem 25I-NBMD compound record. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/25I-NBMD/property/CanonicalSMILES,IUPACName/JSON1
- Obwieszczenie Ministra Zdrowia z dnia 17 czerwca 2024 r. w sprawie ogłoszenia jednolitego tekstu rozporządzenia Ministra Zdrowia w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (Dz.U. 2024 poz. 1139). eli.gov.pl (n.d.). https://eli.gov.pl/api/acts/DU/2024/1139/text.html1
Further Reading
Brandt SD et al. 'Analytical profile of NBOMe and NBMD designer psychedelics'. Drug Testing & Analysis 2014.- Ettrup A et al. 'Radiosynthesis and in vivo evaluation of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers'. European Journal of Nuclear Medicine 2011.
Helander A & Beck O. ‘NBOMe and related substances: a review’. Curr Top Behav Neurosci 2016.- Helander A & Beck O. 'NBOMe and related substances: a review'. Current Topics in Behavioral Neuroscience 2016.
Nikolaou P et al. 'Headspace: A report on 25I-NBMD intoxication'. Journal of Analytical Toxicology 2015.
Reddit: user reports compilation – r/ResearchChemicals search “25I-NBMD” (accessed 2025-08-02)
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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