25I-NBMD
25I-NBMD is a synthetic psychedelic of the substituted phenethylamine class, specifically an N-benzylated derivative of 2C-I.1 It was discovered in 2006 by a research team led by David Nichols at Purdue University. Closely related to the 25X-NBOMe series, it is a highly potent compound that acts as a partial agonist at the 5-HT2A receptor.1 As a research chemical, it has very limited documentation regarding its effects and safety profile in humans.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
25I-NBMD acts as a potent partial agonist at the serotonin 5-HT2A receptor, with a reported Ki of 0.049 nM at the human 5-HT2A receptor. It is a derivative of the phenethylamine hallucinogen 2C-I, featuring an N-benzyl substitution with a methylenedioxy group.1
Pharmacokinetics
Tolerance
Serotonergic psychedelics, 5-HT2A agonists
Harm Potential
Toxicity
No lethal-dose or LD50 data were identified. Avoiding other psychedelics, stimulants, and redosing is advised.
History & Culture
25I-NBMD was discovered in 2006 by a research team at Purdue University led by David Nichols.2 The compound is a derivative of the phenethylamine hallucinogen 2C-I, developed as part of ongoing investigations into serotonin receptor…
Legality
By Country
References
Source Pages
Citations
- (n.d.). Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response. https://pmc.ncbi.nlm.nih.gov/articles/PMC3866097/123
- (December 2006). Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular Pharmacology, 70(6), 1956–64. https://doi.org/10.1124/mol.106.02872012
- (n.d.). Föreskrifter (LVFS 2014:11) om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika. https://lagen.nu/lvfs/2014:111
- (n.d.). The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014, SI 2014/1106. https://www.legislation.gov.uk/uksi/2014/1106/made1
Further Reading
Brandt SD et al. 'Analytical profile of NBOMe and NBMD designer psychedelics'. Drug Testing & Analysis 2014.- Ettrup A et al. 'Radiosynthesis and in vivo evaluation of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers'. European Journal of Nuclear Medicine 2011.
Helander A & Beck O. ‘NBOMe and related substances: a review’. Curr Top Behav Neurosci 2016.- Helander A & Beck O. 'NBOMe and related substances: a review'. Current Topics in Behavioral Neuroscience 2016.
Nikolaou P et al. 'Headspace: A report on 25I-NBMD intoxication'. Journal of Analytical Toxicology 2015.
Reddit: user reports compilation – r/ResearchChemicals search “25I-NBMD” (accessed 2025-08-02)
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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