25c-NBOMe
25C-NBOMe is a synthetic psychedelic of the substituted phenethylamine class and a member of the 25x-NBOMe series, a group of potent compounds derived from the 2C-x family. Discovered in 2003 by Ralf Heim at the Free University of Berlin, it is derived from 2C-C through the addition of an N-benzyl methoxy group, resulting in roughly a sixteen-fold increase in potency. It first appeared on the research chemical market around 2010 and is active in the microgram range.
Contents
Dosage & Duration
Dosage
Insufflation is strongly discouraged due to significantly increased risk of fatal overdose. The potency of this substance and narrow margin between active and toxic doses make accurate dosing in the microgram range extremely difficult via this route. If handled as pure powder, laboratory safety methods (goggles, gloves, mask) must be used to prevent accidental exposure through inhalation or contact with mucous membranes.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 25C-NBOMe can be broken down into several components which progressively intensify proportional to dosage.
Cognitive
The cognitive effects of 25C-NBOMe are described by many as remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, mild to overwhelming cognitive alterations become present; this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.
Visual
Distortions
Enhancements
25C-NBOMe presents a full and complete array of possible visual enhancements.
Geometry
The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages, which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe. In terms of their behaviour, 25C-NBOMe's geometry leads onto Level 8A visual geometry with Level 8B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelopes the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.
Hallucinatory States
25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 - 5 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and identical in behaviour to that of LSD and 25I-NBOMe.
Auditory
The auditory effects of 25C-NBOMe are common in their occurrence and exhibit a full range of effects.
Reagent Testing
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Pharmacology
Pharmacodynamics
25C-NBOMe acts as a potent agonist at serotonin 5-HT2 receptors, with prominent activity at the 5-HT2A receptor. Sources differ on whether its 5-HT2A activity constitutes full or partial agonism.
Pharmacokinetics
Tolerance
Serotonergic psychedelics, All 5-HT2A agonists
Harm Potential
Addiction & Dependence
Psychological
Extremely Low25C-NBOMe does not typically lead to habitual use, and repeated use can make further use less appealing. Since tolerance develops right away, compulsive use is essentially not feasible; patterns of use are usually self-limiting.
Toxicity
Overdose can produce dangerously elevated heart rate and blood pressure, significant vasoconstriction, and in extreme cases cardiac arrest; peripheral vasoconstriction severe enough to require medical attention has been reported even at non-overdose levels.
Rhabdomyolysis has been documented in association with 25C-NBOMe use, representing serious risk of muscle tissue breakdown.
Psychosis Risk
Anxiety and paranoia occur more readily with 25C-NBOMe than with other psychedelics, possibly due to its prominent stimulating properties. Overdose effects include confusion, delirium, delusions, panic attacks, and aggressive behavior.
Seizure Risk
Seizures are a documented risk with NBOMe compounds and appear more frequently during overdose situations. Muscle spasms, dystonia, and clonus have also been reported.
History & Culture
25C-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin. The compound was subsequently investigated by a research team at Purdue University led by David Nichols, and was first formally described in the scientific literature by Anders Ettrup and colleagues in 2010.…
Trip Reports
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Legality
By Country
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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