25c-NBOMe
25C-NBOMe is a synthetic psychedelic of the substituted phenethylamine class and a member of the 25x-NBOMe series, a group of potent compounds derived from the 2C-x family. Discovered in 2003 by Ralf Heim at the Free University of Berlin, it is derived from 2C-C through the addition of an N-benzyl methoxy group, resulting in roughly a sixteen-fold increase in potency. It first appeared on the research chemical market around 2010 and is active in the microgram range.
Dosage & Duration
Dosage
Nasal administration carries a substantially elevated risk of fatal overdose and is strongly discouraged. The compound's high potency combined with a narrow threshold between pharmacologically active and dangerous quantities makes precise microgram-level dosing impractical through this route. When handling the substance in pure powder form, appropriate laboratory precautions—including protective eyewear, gloves, and a respirator—are necessary to avoid unintended exposure via inhalation or mucous membrane contact.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 25C-NBOMe can be broken down into several components which progressively intensify proportional to dosage.
Cognitive
The cognitive effects of 25C-NBOMe are described by many as remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, mild to overwhelming cognitive alterations become present; this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.
Visual
Distortions
Enhancements
25C-NBOMe presents a full and complete array of possible visual enhancements.
Geometry
The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages, which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe. In terms of their behaviour, 25C-NBOMe's geometry leads onto Level 8A visual geometry with Level 8B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelopes the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.
Hallucinatory States
25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 - 5 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and identical in behaviour to that of LSD and 25I-NBOMe.
Auditory
The auditory effects of 25C-NBOMe are common in their occurrence and exhibit a full range of effects.
Pharmacology
Pharmacodynamics
25C-NBOMe acts as a potent agonist at serotonin 5-HT2 receptors, with prominent activity at the 5-HT2A receptor. Sources differ on whether its 5-HT2A activity constitutes full or partial agonism.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Serotonergic psychedelics, All 5-HT2A agonists
Harm Potential
Addiction & Dependence
Psychological
Extremely Low25C-NBOMe does not typically lead to habitual use, and repeated use can make further use less appealing. Since tolerance develops right away, compulsive use is essentially not feasible; patterns of use are usually self-limiting.
Toxicity
Overdose can produce dangerously elevated heart rate and blood pressure, significant vasoconstriction, and in extreme cases cardiac arrest; peripheral vasoconstriction severe enough to require medical attention has been reported even at non-overdose levels.
Rhabdomyolysis has been documented in association with 25C-NBOMe use, representing serious risk of muscle tissue breakdown.
Psychosis Risk
Anxiety and paranoia occur more readily with 25C-NBOMe than with other psychedelics, possibly due to its prominent stimulating properties. Overdose effects include confusion, delirium, delusions, panic attacks, and aggressive behavior.
Seizure Risk
Seizures are a documented risk with NBOMe compounds and appear more frequently during overdose situations. Muscle spasms, dystonia, and clonus have also been reported.
History & Culture
25C-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin. The compound was subsequently investigated by a research team at Purdue University led by David Nichols, and was first formally described in the scientific literature by Anders Ettrup and colleagues in 2010.…
Trip Reports
Loading related reports
Preparing section content
Still loading. Refresh if this section does not appear.
Legality
International
25c-NBOMe is not listed under the 1961 Single Convention on Narcotic Drugs. It is not listed under the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
By Country
References
Citations
- Criminal Code Regulations 2019, Schedule 2. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
- Criminal Code Regulations 2019, Schedule 2. legislation.gov.au (n.d.). https://www.legislation.gov.au/F1996B03651/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
- Suchtgiftverordnung, Anlage V. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/eli/bgbl/II/2019/160/201906261
- Portaria SVS/MS nº 344/1998, Lista F2. bvsms.saude.gov.br (n.d.). https://bvsms.saude.gov.br/bvs/saudelegis/svs/1998/prt0344_12_05_1998_rep.html1
- Controlled Drugs and Substances Act, Schedule III. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/FullText.html1
- Decreto N° 1690 de 2015. leychile.cl (n.d.). https://www.leychile.cl/navegar?idNorma=10758051
- Nařízení vlády č. 463/2013 Sb., o seznamech návykových látek (Government Regulation No. 463/2013 Coll., on lists of addictive substances). e-sbirka.cz (n.d.). https://www.e-sbirka.cz/sb/2013/463?zalozka=text1
- Nařízení vlády č. 463/2013 Sb., o seznamech návykových látek (Government Regulation No. 463/2013 Coll., on lists of addictive substances). e-sbirka.cz (n.d.). https://www.e-sbirka.cz/sb/1998/167?zalozka=text1
- Bekendtgørelse om euforiserende stoffer, nr. 405 af 26. marts 2026. retsinformation.dk (n.d.). https://www.retsinformation.dk/eli/lta/2026/405/pdf1
- Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista 543/2008. finlex.fi (n.d.). https://finlex.fi/fi/lainsaadanto/2008/5431
- Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista 543/2008. finlex.fi (n.d.). https://finlex.fi/en/legislation/collection/2015/611
- Arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants. legifrance.gouv.fr (n.d.). https://www.legifrance.gouv.fr/loda/id/JORFTEXT000000533085/2026-07-141
- Arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants. legifrance.gouv.fr (n.d.). https://www.legifrance.gouv.fr/jorf/id/JORFTEXT0000314450401
- Betäubungsmittelgesetz, Anlage I. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html1
- Notification S.O. 2374(E), 12 July 2016, under the NDPS Act 1985. narcoticsindia.nic.in (n.d.). https://www.narcoticsindia.nic.in/Notifications/Notification-dated-12.07.2016-notifying-new-narcotic-drug-under-NDPS-Act-1985.pdf1
- Misuse of Drugs (Controlled Drugs) (Designation) Order 2022 (S.I. No. 211/2022). irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2022/si/211/made/en/print1
- D.P.R. 309/1990, Tabella I. normattiva.it (n.d.). https://www.normattiva.it/uri-res/N2Ls?urn:nir:stato:decreto.del.presidente.della.repubblica:1990-10-09;3091
- 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令 (Cabinet Order Designating Narcotics, Narcotic Raw Materials Plants, Psychotropics and Narcotic/Psychotropic Raw Materials), Article 1, item 30. elaws.e-gov.go.jp (n.d.). https://elaws.e-gov.go.jp/api/1/lawdata/402CO00000002381
- 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令 (Cabinet Order Designating Narcotics, Narcotic Raw Materials Plants, Psychotropics and Narcotic/Psychotropic Raw Materials), Article 1, item 30. elaws.e-gov.go.jp (n.d.). https://elaws.e-gov.go.jp/api/1/lawdata/328AC00000000141
- Diario Oficial de la Federación, 1 September 2022 tariff publication. dof.gob.mx (n.d.). https://www.dof.gob.mx/nota_detalle_popup.php?codigo=56088301
- Diario Oficial de la Federación, 1 September 2022 tariff publication. dof.gob.mx (n.d.). https://www.dof.gob.mx/abrirPDF.php?anio=2022&archivo=01092022-MAT.pdf&repo=repositorio%2F1
- Opiumwet, lijst I. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/Opiumwet1
- Misuse of Drugs Act 1975, section 3A. legislation.govt.nz (n.d.). https://www.legislation.govt.nz/act/public/1975/0116/latest/DLM436576.html1
- Forskrift om narkotika (narkotikaforskriften). lovdata.no (n.d.). https://lovdata.no/dokument/SF/forskrift/2013-02-14-199/%C2%A751
- Dangerous Drugs Board, Updated Lists of Controlled Substances. ddb.gov.ph (n.d.). https://ddb.gov.ph/wp-content/uploads/2025/08/Updated-Lists-of-controlled-substances-as-of-July-2025.pdf1
- Lei n.º 49/2021, Tabela II-A do Decreto-Lei n.º 15/93. files.dre.pt (n.d.). https://files.dre.pt/gratuitos/1s/2021/07/14200.pdf1
- Misuse of Drugs Act 1973, First Schedule. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/Act/MDA1973?Phrase=class+c&ProvIds=Sc1-&ViewType=Within&WiAl=11
- Enforcement Decree of the Narcotics Control Act, Annex 3. law.go.kr (n.d.). https://www.law.go.kr/LSW/flDownload.do?bylClsCd=110201&flSeq=122359021&gubun=1
- Orden SSI/748/2016, de 11 de mayo. boe.es (n.d.). https://www.boe.es/diario_boe/txt.php?id=BOE-A-2016-47371
- LVFS 2013:15. lakemedelsverket.se (n.d.). https://www.lakemedelsverket.se/4aaf5b/globalassets/dokument/lagar-och-regler/foreskrifter/lvfs-2013-15.pdf1
- Betäubungsmittelverzeichnisverordnung, Verzeichnis d. fedlex.admin.ch (n.d.). https://www.fedlex.admin.ch/eli/cc/2011/363/de1
- Thailand FDA Narcotics List. permitfortraveler.fda.moph.go.th (n.d.). https://permitfortraveler.fda.moph.go.th/nct_permit_main/Upload/NARCO_list_update_15_09_2025_NEW.pdf1
- Council of Ministers Decision No. 2015/7238 on Subjecting Certain Substances to Law No. 2313 on the Control of Narcotic Drugs. resmigazete.gov.tr (n.d.). https://www.resmigazete.gov.tr/eskiler/2015/02/20150206-11.htm1
- Council of Ministers Decision No. 2015/7238 on Subjecting Certain Substances to Law No. 2313 on the Control of Narcotic Drugs. mevzuat.gov.tr (n.d.). https://www.mevzuat.gov.tr/mevzuatmetin/1.3.2313.pdf1
- Council of Ministers Decision No. 2015/7238 on Subjecting Certain Substances to Law No. 2313 on the Control of Narcotic Drugs. unodc.org (n.d.). https://www.unodc.org/LSS/Substance/Details/be41b648-e8e7-4a5b-bec3-51af6c128a9b1
- Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, as amended by Resolution No. 390 of 16 May 2018. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/go/390-2018-%D0%BF1
- Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, as amended by Resolution No. 390 of 16 May 2018. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/770-2000-%D0%BF/ed202312231
- Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, as amended by Resolution No. 390 of 16 May 2018. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/go/60/95-%D0%B2%D1%801
- Misuse of Drugs Act 1971, Schedule 2 Part I. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- 21 CFR 1308.11. ecfr.gov (n.d.). https://www.ecfr.gov/current/title-21/chapter-II/part-1308/section-1308.111
- Me. Rev. Stat. tit. 17-A, §§ 1101(11), 1102. legislature.maine.gov (n.d.). https://legislature.maine.gov/statutes/17-A/title17-Asec1101.html1
- Me. Rev. Stat. tit. 17-A, §§ 1101(11), 1102. legislature.maine.gov (n.d.). https://legislature.maine.gov/statutes/17-A/title17-Asec1102.html1
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the 25c-NBOMe article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.