white → yellow2 → orange2
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25c-NBOMe
25C-NBOMe is a synthetic psychedelic of the substituted phenethylamine class and a member of the 25x-NBOMe series, a group of potent compounds derived from the 2C-x family. Discovered in 2003 by Ralf Heim at the Free University of Berlin, it is derived from 2C-C through the addition of an N-benzyl methoxy group, resulting in roughly a sixteen-fold increase in potency. It first appeared on the research chemical market around 2010 and is active in the microgram range.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~25 µg
Light25-250 µg
Moderate250-500 µg
Strong500-700 µg
Heavy700+ µg
Nasal administration carries a substantially elevated risk of fatal overdose and is strongly discouraged. The compound's high potency combined with a narrow threshold between pharmacologically active and dangerous quantities makes precise microgram-level dosing impractical through this route. When handling the substance in pure powder form, appropriate laboratory precautions—including protective eyewear, gloves, and a respirator—are necessary to avoid unintended exposure via inhalation or mucous membrane contact.
Duration
Onset0-5 minutes
Come Up15-30 minutes
Peak2-4 hours
Offset1-3 hours
Total4-8 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 25C-NBOMe can be broken down into several components which progressively intensify proportional to dosage.
Cognitive
The cognitive effects of 25C-NBOMe are described by many as remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, mild to overwhelming cognitive alterations become present; this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.
Visual
Distortions
Enhancements
25C-NBOMe presents a full and complete array of possible visual enhancements.
Geometry
The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages, which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe. In terms of their behaviour, 25C-NBOMe's geometry leads onto Level 8A visual geometry with Level 8B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelopes the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.
Hallucinatory States
25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 - 5 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and identical in behaviour to that of LSD and 25I-NBOMe.
Auditory
The auditory effects of 25C-NBOMe are common in their occurrence and exhibit a full range of effects.
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
25C-NBOMe acts as a potent agonist at serotonin 5-HT2 receptors, with prominent activity at the 5-HT2A receptor. Sources differ on whether its 5-HT2A activity constitutes full or partial agonism.
Pharmacokinetics
Absorption & half-lifenot documented yetMetabolitesnone documented yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Full Tolerance
Tolerance to the effects of 25C-NBOMe develops almost immediately after ingestion. This rapid tolerance buildup makes compulsive use essentially impossible, as the substance becomes self-regulating through this mechanism.
Baseline Reset
Full baseline tolerance typically returns after approximately 14 days of abstinence, though some sources suggest this period may extend to 2-3 weeks.
Half Tolerance
Approximately 7 days after use, tolerance is estimated to reduce to half of its peak level.
Cross Tolerance
Serotonergic psychedelics, All 5-HT2A agonists
Harm Potential
Addiction & Dependence
Psychological
Extremely Low25C-NBOMe does not typically lead to habitual use, and repeated use can make further use less appealing. Since tolerance develops right away, compulsive use is essentially not feasible; patterns of use are usually self-limiting.
Toxicity
Cardiovascular
Overdose can produce dangerously elevated heart rate and blood pressure, significant vasoconstriction, and in extreme cases cardiac arrest; peripheral vasoconstriction severe enough to require medical attention has been reported even at non-overdose levels.
Musculoskeletal
Rhabdomyolysis has been documented in association with 25C-NBOMe use, representing serious risk of muscle tissue breakdown.
Psychosis Risk
Anxiety and paranoia occur more readily with 25C-NBOMe than with other psychedelics, possibly due to its prominent stimulating properties. Overdose effects include confusion, delirium, delusions, panic attacks, and aggressive behavior.
Seizure Risk
Seizures are a documented risk with NBOMe compounds and appear more frequently during overdose situations. Muscle spasms, dystonia, and clonus have also been reported.
History & Culture
25C-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin. The compound was subsequently investigated by a research team at Purdue University led by David Nichols, and was first formally described in the scientific literature by Anders Ettrup and colleagues in 2010.…
Trip Reports
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Legality
International
25c-NBOMe is not listed under the 1961 Single Convention on Narcotic Drugs. It is not listed under the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
By Country
Illegal33
United StatesIllegal21 CFR 1308.1154
Emergency scheduled by the DEA on November 15, 2013, along with 25B-NBOMe and 25I-NBOMe under the Controlled Substances Act. The temporary scheduling was extended in November 2015. Several states including Arkansas, Georgia, and Louisiana added it to their Schedule I lists prior to federal action. Scheduling also makes other NBOMe compounds probable Controlled Substance Analogues when intended for human consumption.
By state
Across the 50 states, D.C., and the permanent territories, most jurisdictions treat 25c-NBOMe consistently with federal control; listed entries record independently verified differences in state classification or coverage.
MaineNot scheduled25C-NBOMe is not named or described in Maine's schedules W, X, Y, or Z. Maine defines a scheduled drug as a drug named or described in those schedules, and its Schedule W synthetic-hallucinogen provision does not include 25C-NBOMe. The substance therefore lacks the state scheduled-drug classification that corresponds to federal Schedule I status.
AustriaIllegalSuchtgiftverordnung, Anlage V3
Prohibited since June 26, 2019 under the Suchtmittelgesetz (SMG). Possession, production, and sale are illegal.
BrazilIllegalPortaria SVS/MS nº 344/1998, Lista F24
Listed on Portaria SVS/MS nº 344 as of February 18, 2014. The entire NBOMe series became controlled at this time, including 25I-, 25C-, 25D-, 25B-, 25E-, 25N-, 25P-, 25T2-, 25T7-, and 25H-NBOMe.
CanadaIllegal (analog/blanket ban)Controlled Drugs and Substances Act, Schedule III5
Controlled as of October 31, 2016 as a derivative of 2,5-dimethoxyphenethylamine under the Controlled Drugs and Substances Act.
ChileIllegalDecreto N° 1690 de 20156
25C-NBOMe is included in Chile's controlled-substances schedule. Decreto No. 1690 adds it to the list in Article 1 of Supreme Decree No. 867 of 2007.
ChinaIllegal25C-NBOMe has been controlled in China since 1 October 2015 and is listed as 2C-C-NBOMe in item 3 of the current non-medicinal catalogue. Experimental research is permitted under the applicable regulations, but production, purchase, sale, transport, use, storage, import, and export are otherwise prohibited.
DenmarkIllegal (analog/blanket ban)Bekendtgørelse om euforiserende stoffer, nr. 405 af 26. marts 202613
25C-NBOMe is controlled through the phenethylamine group in Denmark's Order on Euphoriant Substances: its N-(2-methoxybenzyl)-2-phenylethan-1-amine structure carries methoxy, chloro, and alkoxy ring substitutions covered by that group definition. It is a Liste B euphoriant substance, which may be used only for medical and scientific purposes; import, export, manufacture, trade, receipt, and possession require compliance with the Order and the relevant Danish Medicines Agency authorization rules. The current Order takes effect on 29 March 2026.
GermanyIllegalBetäubungsmittelgesetz, Anlage I18
Listed in Anlage I of the Betäubungsmittelgesetz (Narcotics Act) since December 13, 2014. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without a license are prohibited.
IndiaIllegalNotification S.O. 2374(E), 12 July 2016, under the NDPS Act 198519
25C-NBOMe is notified as a psychotropic substance in India under the Narcotic Drugs and Psychotropic Substances Act 1985. The notification also identifies it as 2C-C-NBOMe.
IrelandIllegalMisuse of Drugs (Controlled Drugs) (Designation) Order 2022 (S.I. No. 211/2022)20
25C-NBOMe is a designated controlled drug in Ireland. The designation applies to the substance identified by its chemical name and the name 25C-NBOMe.
IsraelIllegalDangerous Drugs Ordinance [New Version], 5733-1973, First Schedule, Part A, Division B, item 13ט(מו), as amended by the Dangerous Drugs Notice (Change of the First Schedule to the Ordinance), 5774-2014212223
25C-NBOMe is currently listed by that name and as 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine as a dangerous drug in item 13ט(מו) of Part A, Division B of the First Schedule to the Dangerous Drugs Ordinance [New Version], 5733-1973. The listing took effect on 7 August 2014 under the Dangerous Drugs Notice (Change of the First Schedule to the Ordinance), 5774-2014. Without permission under the Ordinance or regulations or a licence from the Director, the law prohibits manufacture, production, preparation, extraction, possession, use, export, import, facilitation of export or import, trade, other transactions, and supply. Therapeutic use is permitted when the drug is supplied by an authorized professional under section 11(3) or under licence, but this is not a general recreational-use exception; the definition also covers every salt and every preparation, compound, mixture, or solution of the listed substance and their salts.
ItalyIllegalD.P.R. 309/1990, Tabella I24
Classified as a Schedule I controlled substance. Possession, distribution, and manufacture are illegal.
LatviaIllegal (analog/blanket ban)In Latvia, 25C-NBOMe is controlled in Schedule I through the generic class for 2,5-dimethoxyphenethylamines rather than by an individual listing. The broadened generic definition took effect on 1 June 2021, and its structural terms cover 25C-NBOMe as a ring-chlorinated, nitrogen-substituted derivative of 2-(2,5-dimethoxyphenyl)ethanamine. Schedule I activities are generally prohibited, although the State Agency of Medicines may authorize specified medical or veterinary scientific research, determination of physical and chemical properties, or training.
NetherlandsIllegalOpiumwet, lijst I33
25C-NBOMe is included in List I of the Dutch Opium Act. List I substances are subject to the Act's prohibitions on import, manufacture, possession, sale, supply and transport.
New ZealandIllegal (analog/blanket ban)Misuse of Drugs Act 1975, section 3A34
Considered substantially similar in chemical structure to the controlled hallucinogen DOB and therefore treated as a Class C controlled drug analogue. Withdrawn from sale in early 2012 following a statement by Associate Health Minister Peter Dunne.
NorwayIllegalForskrift om narkotika (narkotikaforskriften)35
25C-NBOMe is listed in Norway's narcotics schedule as 2C-C-NBOMe. The narcotics regulation prohibits conduct involving listed substances under section 5.
PhilippinesIllegalDangerous Drugs Board, Updated Lists of Controlled Substances36
25C-NBOMe is included in the Philippine Dangerous Drugs Board's updated list of controlled substances. The Board's list identifies the substance by its short and chemical names.
PortugalIllegalLei n.º 49/2021, Tabela II-A do Decreto-Lei n.º 15/9337
25C-NBOMe is listed in Portugal's Table II-A of controlled psychotropic substances. The table forms part of the controlled-substances schedules under Decree-Law No. 15/93.
RussiaIllegal (analog/blanket ban)Постановление Правительства Российской Федерации от 30 июня 1998 г. № 681, Список I, позиция «2-(2,5-диметоксифенил)-N-(2-метоксибензил)этанамин и его производные», примечание 638
25C-NBOMe is covered as a derivative of the List I entry for 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine under Government Resolution No. 681, rather than being listed there by its common name or full 4-chloro chemical name. Its replacement of the phenyl-ring hydrogen at position 4 with chlorine leaves the carbon count unchanged and therefore fits the substitution rule in Note 6, subject to the note's exclusions for substances independently entered in the State Register of Medicines or the controlled list. Circulation under the List I regime is prohibited except for purposes expressly permitted by federal law; the directly relevant parent-and-derivatives entry was added by Resolution No. 448 of 8 May 2015, while the broader entry added in 2011 does not establish an October 2011 control date for 25C-NBOMe.
SingaporeIllegalMisuse of Drugs Act 1973, First Schedule39
25C-NBOMe is a Class A controlled drug in Singapore. The First Schedule includes its chemical name and provides that preparations containing scheduled substances are controlled drugs.
South KoreaIllegalEnforcement Decree of the Narcotics Control Act, Annex 342
25C-NBOMe is listed as a psychotropic drug in South Korea. The annex identifies it by its Korean name, short name and chemical name.
SpainIllegalOrden SSI/748/2016, de 11 de mayo43
25C-NBOMe is included in List I of Annex I to Spain's psychotropic-substances control decree. The order applies the control measures and criminal sanctions applicable to substances in that list.
SwedenIllegalLVFS 2013:1544
Added to Schedule I (substances without medical use) as of August 1, 2013, published in Medical Products Agency regulation LVFS 2013:15.
SwitzerlandIllegalBetäubungsmittelverzeichnisverordnung, Verzeichnis d45
Specifically named as a controlled substance under Verzeichnis D of Swiss narcotics legislation.
ThailandIllegalThailand FDA Narcotics List46
25C-NBOMe is listed as a Category I narcotic in Thailand. Category I is the schedule used for narcotics without recognized medical use under the Thai narcotics-control regime.
UkraineIllegalCabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, as amended by Resolution No. 390 of 16 May 2018505152
25C-NBOMe is a psychotropic substance in List No. 2 of Table I of Ukraine’s List of Narcotic Drugs, Psychotropic Substances and Precursors. Resolution No. 390 inserted the substance under its synonym 2C-С-NBOMe on 16 May 2018. Its circulation is prohibited except for the narrowly specified purposes permitted for Table I, List No. 2 substances; unauthorized possession, production, and sale are therefore unlawful.
United KingdomIllegalMisuse of Drugs Act 1971, Schedule 2 Part I53
Controlled as a Class A substance since June 2014 under the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971. Previously subject to a temporary class drug order from June 10, 2013.
Controlled / restricted2
MexicoRestrictedReferences
Citations
- Criminal Code Regulations 2019, Schedule 2. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
- Criminal Code Regulations 2019, Schedule 2. legislation.gov.au (n.d.). https://www.legislation.gov.au/F1996B03651/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
- Suchtgiftverordnung, Anlage V. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/eli/bgbl/II/2019/160/201906261
- Portaria SVS/MS nº 344/1998, Lista F2. bvsms.saude.gov.br (n.d.). https://bvsms.saude.gov.br/bvs/saudelegis/svs/1998/prt0344_12_05_1998_rep.html1
- Controlled Drugs and Substances Act, Schedule III. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/FullText.html1
- Decreto N° 1690 de 2015. leychile.cl (n.d.). https://www.leychile.cl/navegar?idNorma=10758051
- 我国管制毒品目录（2026年7月更新，540种+三大类）. ga.sz.gov.cn (n.d.). https://ga.sz.gov.cn/SZJDZX/SZBMFW/content/post_12898420.html1
- 麻醉药品和精神药品管理条例 (Regulations on the Administration of Narcotic Drugs and Psychotropic Substances), third revision. xzfg.moj.gov.cn (n.d.). https://xzfg.moj.gov.cn/front/law/detail?LawID=17441
- 非药用类麻醉药品和精神药品列管办法 (Measures for Scheduling Non-Medicinal Narcotic Drugs and Psychotropic Substances). gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
- 三部门联合发布最新版《非药用类麻醉药品和精神药品目录》. btgaj.xjbt.gov.cn (n.d.). https://btgaj.xjbt.gov.cn/c/2025-07-28/8428464.shtml1
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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