white → brown1 → green2
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25b-NBOMe
25B-NBOMe is a synthetic psychedelic of the substituted phenethylamine class and a member of the 25x-NBOMe series. It is an N-benzyl derivative of 2C-B, first described by Ralf Heim at the Free University of Berlin. The substance had virtually no history of human use before appearing on the research chemical market in 2010. Compared to its parent compound 2C-B, 25B-NBOMe is reported to be approximately sixteen times more potent.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~50 µg
Light50-300 µg
Moderate300-500 µg
Strong500-700 µg
Heavy700+ µg
The blotter should be held under the tongue for 15 to 30 minutes to allow adequate absorption, as this compound has very low bioavailability when swallowed. Deaths have been reported at heavy doses.
Duration
Onset20-40 minutes
Come Up30-90 minutes
Peak4-6 hours
Offset2-4 hours
After Effects2-6 hours
Total8-12 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 25B-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage.
Cognitive
The head space of 25B-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.
Visual
Geometry
The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages. In terms of their behaviour, 25B-NBOMe's geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.
Hallucinatory States
25B-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.
Auditory
The auditory effects of 25B-NBOMe are common in their occurrence and exhibit a full range of effects.
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
25B-NBOMe is a selective serotonin 5-HT2 receptor agonist that acts as a potent partial agonist at the 5-HT2A receptor. It binds with high affinity to 5-HT2A, 5-HT2B, and 5-HT2C receptors, though the degree of subtype selectivity varies between studies: one reported similar affinity across all three subtypes (Ki = 0.5–1.7 nM), while another found 12- to 20-fold selectivity for 5-HT2A (Ki = 0.5 nM) over 5-HT2B and 5-HT2C (Ki = 10 and 6.2 nM, respectively). The compound is highly selective for 5-HT2 receptors over other serotonin receptors, monoamine receptors, and monoamine transporters (>200-fold). In rodent models, 25B-NBOMe increases cortical and subcortical levels of glutamate, serotonin, dopamine, and acetylcholine, with these elevations following an inverted U-shaped dose-response curve. It also acts as a low-potency partial agonist at rat and mouse TAAR1, though it is inactive at the human form of this receptor.
Pharmacokinetics
Absorption & half-lifenot documented yetMetabolitesnone documented yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Full Tolerance
Tolerance to the effects of 25B-NBOMe develops almost immediately after ingestion. This rapid tolerance buildup makes compulsive use essentially impossible, as subsequent doses within the tolerance window produce markedly diminished effects.
Baseline Reset
Approximately 2 weeks in the absence of further consumption
Half Tolerance
Approximately 1 week
Cross Tolerance
Psychedelics (all serotonergic psychedelics will have reduced effect following 25B-NBOMe consumption)
Harm Potential
Addiction & Dependence
Psychological
Low25B-NBOMe has demonstrated reinforcing effects in rodent studies, producing conditioned place preference and self-administration with robust dopamine elevation in the nucleus accumbens. However, the rapid tolerance development that occurs immediately after ingestion makes compulsive use essentially impossible, and the substance is generally considered not habit-forming with desire to use often decreasing after experiences.
Toxicity
Cardiovascular
Vasoconstriction, tachycardia, and elevated blood pressure commonly occur during intoxication; in overdose situations these effects intensify significantly and may potentially result in organ failure or cardiac arrest.
Psychosis Risk
Overdose effects commonly include confusion, delusions, panic attacks, and aggressive behavior. These psychotomimetic effects appear dose-dependent and are more likely at higher doses.
Seizure Risk
NBOMes have shown a tendency to cause severe seizures, which are commonly reported among overdose symptoms. The substance appears to lower seizure threshold.
History & Culture
25B-NBOMe was first described in the scientific literature by Ralf Heim and colleagues at the Free University of Berlin, with initial findings presented in conference abstracts as early as 1999. The compound was subsequently characterized in more detail through continued research at the institution…
Legality
International
25B-NBOMe is listed in Schedule I of the Convention on Psychotropic Substances of 1971.
By Country
Illegal28
United StatesIllegalControlled Substances Act70
Placed in Schedule I of the Controlled Substances Act by the DEA in November 2013 using emergency scheduling powers, alongside 25I-NBOMe and 25C-NBOMe. Manufacturing, purchase, possession, processing, and distribution are prohibited.
AustriaIllegalSuchtgiftverordnung; Suchtmittelgesetz1
Prohibited under the Suchtmittelgesetz (Narcotic Substances Act) since June 26, 2019. Possession, production, and sale are illegal.
BelgiumIllegal25B-NBOMe is listed by name in Annex IIA, Belgium's list corresponding to Table I of the 1971 Convention on Psychotropic Substances. The Royal Decree applies to listed substances and requires prior authorization for import, export, transport, manufacture, possession, sale, supply, or acquisition. Authorizations are limited to scientific or medical purposes; for Annex IIA substances they are only available for scientific or very limited medical purposes through duly authorized medical or scientific establishments.
BrazilIllegalPortaria SVS/MS nº 344, de 12 de maio de 1998, Anexo I, Lista F2, Atualização nº 101, published by RDC ANVISA nº 1.036, de 9 de julho de 2026456
The current consolidated Anexo I is Atualização nº 101 under RDC ANVISA nº 1.036/2026. It retains 25B-NBOMe in Lista F2; Lista F is headed ‘LISTA DAS SUBSTÂNCIAS DE USO PROSCRITO NO BRASIL.’ RDC nº 970/2025 is the preceding consolidated republication, not the current instrument.
CanadaIllegalControlled Drugs and Substances Act7
Controlled under Schedule III of the Controlled Drugs and Substances Act as of October 31, 2016. Classified as a derivative of 2,5-dimethoxyphenethylamine.
ChinaIllegalCatalogue of Non-Medicinal Narcotic Drugs and Psychotropic Substances (2025 edition), item 18910111213
China lists 25B-NBOMe as a non-medicinal controlled substance under its exact chemical name and the abbreviation 2C-B-NBOMe in item 1 of the 2025 catalogue. It has been controlled since 1 October 2015, and the listing also covers possible salts, stereoisomers and their salts unless otherwise specified. Non-medicinal controlled substances may be used for experimental research under the governing regulations, but production, trade, use, storage and transport are prohibited; other laws prohibit unlawful supply and possession and require licences for import and export.
Czech RepublicIllegalIn the Czech Republic, 25B-NBOMe is a prohibited List No. 4 psychotropic substance. Research, manufacture, processing, storage, supply, use, purchase, and sale generally require a handling permit, subject to statutory exceptions. Unauthorized production, import, export, transit, offering, brokering, sale, supply to another person, or possession for another person is punishable by one to five years' imprisonment; unauthorized personal possession of more than a small amount is punishable by up to two years' imprisonment, disqualification, or forfeiture.
DenmarkIllegal (analog/blanket ban)Bekendtgørelse om euforiserende stoffer (BEK nr. 405 af 26/03/2026), bilag 1, liste B, nr. 46022
25B-NBOMe is covered by Liste B's phenethylamine group: the definition includes N-(methoxybenzyl)-2-phenylethan-1-amine derivatives with alkyl, alkoxy, alkandiylbis(oxy), or halogen ring substitutions. Liste B substances may only be used for medical and scientific purposes; their import, supply, manufacture, possession, and other activity are subject to the order's controls and permissions.
FinlandIllegalGovernment Decree on substances, preparations and plants considered as narcotics (543/2008), Annex II, Schedule I of the 1971 Convention2324
25B-NBOMe is listed by name and chemical name in Annex II, Schedule I of Finland's Government Decree 543/2008. The current 2025 amendment retains that listing. Finland's Ministry of Social Affairs and Health states that production, manufacture, import, export, transport, distribution, trade, handling, possession, and use of narcotics are prohibited, subject to specified medical, scientific, investigative, and control-purpose exceptions.
GermanyIllegalBetäubungsmittelgesetz25
Controlled under Anlage I of the Betäubungsmittelgesetz (Narcotics Act) since December 13, 2014. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without license are prohibited.
IndonesiaIllegalMinister of Health Regulation No. 15 of 2025 on Amendments to the Classification of Narcotics (Berita Negara Republik Indonesia 2025 No. 989), promulgated 28 November 202526
The Ministry of Health text places 25B-NBOMe at item 67 of the Group I annex. Article 1(2) defines Group I as narcotics usable only for scientific development and not for therapy. Article 3 expressly repeals Minister of Health Regulation No. 7 of 2025.
IrelandIllegalMisuse of Drugs Regulations 2017 (S.I. No. 173 of 2017)27
25B-NBOMe is listed in Schedule 1 of the Misuse of Drugs Regulations 2017. The Regulations prohibit production, supply, import and export of a controlled drug except as authorised, and limit lawful possession to specified exemptions.
JapanIllegalCabinet Order Designating Narcotics35
Designated as a narcotic drug under Japanese law, effective November 1, 2015.
LatviaIllegal (analog/blanket ban)25B-NBOMe is covered by Latvia's generic I-list entry for 2,5-dimethoxyphenethylamines rather than being named individually. That entry covers compounds derived from 2-(2,5-dimethoxyphenyl)ethanamine, including ring substitution and substitution of one or two nitrogen hydrogens with an unsubstituted or substituted alkyl group. The I list comprises prohibited especially dangerous narcotic substances and equivalent psychotropic substances; the legal-circulation law prohibits their manufacture, import, export, distribution, possession, acquisition, use, and transit.
NetherlandsIllegalOpiumwet38
25B-NBOMe is named in Lijst I of the Opiumwet. Article 2 prohibits importing, exporting, preparing, processing, selling, supplying, transporting, possessing and manufacturing substances in that list except where the Act provides an exemption or authorisation.
New ZealandIllegal25B-NBOMe is expressly listed as a Class B controlled drug in Schedule 2, Part 1 of the Misuse of Drugs Act 1975. Importing, exporting, producing, manufacturing, supplying, administering, possessing, or using it is prohibited except where the Act, a licence, or regulations provide lawful authority. Possession of 25 milligrams or more, or 25 or more flakes, tablets, capsules, or other drug forms containing any quantity, creates a presumption that the drug is held for supply; this threshold is not a lawful personal-possession allowance. A section 6 offence involving a Class B controlled drug may carry up to 14 years' imprisonment.
NorwayIllegalForskrift om narkotika (narkotikaforskriften), narkotikalisten44
25B-NBOMe is listed under the synonym 2C-B-NBOMe in Norway's narcotics list. The listed chemical name identifies the substance as 2,5-dimetoksy-4-brom-N-(2-metoksybenzyl)fenetylamin, so the listed name and chemical name cover this substance.
PhilippinesIllegal1971 Convention on Psychotropic Substances, Schedule I (Philippine scheduled controlled-substances list)45
25B-NBOMe is listed by the Philippine Dangerous Drugs Board in the Schedule I substances of the 1971 Convention on Psychotropic Substances. The Board's current scheduled controlled-substances list gives its chemical name as 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine.
PolandIllegalRozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych, załącznik nr 1, część 1 (Substancje psychotropowe grupy I-P), poz. 10, as amended by Dz. U. 2025 poz. 598 and Dz. U. 2026 poz. 934464748
25B-NBOMe is expressly listed at item 10 in Annex 1, Group I-P. The subsequent official amendments effective 22 May 2025 and 28 July 2026 identify the Group I-P items they alter (item 7 in 2025; item 96 and repeal of item 99 in 2026), not item 10; the listed 25B-NBOMe entry therefore remains in force after those amendments.
PortugalIllegalDecreto-Lei n.º 15/93, de 22 de janeiro, Tabela II-A, as republished by Lei n.º 23/2025, de 7 de março49
Lei n.º 23/2025 republished the current Tabela II-A annexed to Decreto-Lei n.º 15/93 and expressly includes this substance. The table also covers its salts where possible and specifically designated isomers.
RussiaIllegal (analog/blanket ban)In Russia, 25B-NBOMe is covered by the generic derivative provisions of List I rather than being named as an independent entry. List I includes 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine and its derivatives, and 25B-NBOMe falls within the instrument’s structural definition of a derivative. The parent entry was introduced by Government Resolution No. 448 of 8 May 2015, and List I prohibits the circulation of the substances it covers.
SingaporeIllegal25B-NBOMe is currently specified as a Class A controlled drug in Part 1 of the Act's First Schedule. The Act defines a controlled drug to include a substance specified in that Schedule and makes trafficking in a controlled drug an offence except as authorised. The current Fourth Schedule to the Misuse of Drugs Regulations independently lists the same substance and positional-isomer coverage as a controlled drug subject to specified regulatory requirements. The 2018 Act amendment and the parallel Regulations amendment both commenced on 1 May 2018.
South KoreaIllegalEnforcement Decree of the Narcotics Control Act, Annex 359
South Korea lists 25B-NBOMe as item 82 among psychotropic drugs under Article 2(3)(a) of the Narcotics Control Act. The Annex identifies it as 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine and applies the listing to its salts, isomers, and salts of isomers.
SwedenIllegalFörordning (1992:1554) om kontroll av narkotika, bilaga 1, gällande t.o.m. SFS 2026:110960
The current official consolidated text states in 2 § that substances in bilaga 1 are to be considered narcotics under narkotikastrafflagen (1968:64). Bilaga 1 expressly lists the designated substance and alias.
SwitzerlandIllegal25B-NBOMe is listed by name and chemical name in Verzeichnis d of the Swiss Betäubungsmittelverzeichnisverordnung. Switzerland treats Verzeichnis-d substances as prohibited narcotics; import, cultivation, manufacture, and marketing require a Federal Office of Public Health exception permit unless a stated statutory exception applies.
ThailandIllegalTable of Controlled Narcotic Drugs under Narcotics Code B.E. 2564 (2021)63
Thailand's Food and Drug Administration lists 25B-NBOMe in its Table of Controlled Narcotic Drugs under the Narcotics Code. The table places it in Category I.
TurkeyIllegal (analog/blanket ban)26/1/2015 tarihli ve 2015/7238 sayılı Bakanlar Kurulu Kararı, ekli liste, as amended by 2016/8548; Uyuşturucu Maddelerin Murakabesi Hakkında Kanun, Kanun No. 23136465666768
25B-NBOMe is covered by Turkey's structurally defined amphetamine (phenethylamine) derivatives because its unsubstituted ethyl chain, N-(2-methoxybenzyl) group, ring methoxy groups, and bromine fall within the family's permitted hydrogen, methoxybenzyl, alkoxy, and halogen substitutions. The annex to Decision No. 2015/7238, as amended by Decision No. 2016/8548, subjects this family to Law No. 2313; the original decision took effect on publication on 6 February 2015. Manufacture, import, export, sale, supply, dispatch, transport, storage, purchase, acceptance, and possession are controlled when undertaken without or contrary to a licence, while purchase, acceptance, or possession for personal use and use are separately covered.
United KingdomIllegalMisuse of Drugs Act 197169
Controlled as a Class A substance under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause. Class A carries the most severe penalties for possession and supply.
Legal / decriminalized1
ItalyDecriminalized25B-NBOMe (also listed as 2C-B-NBOMe) has been expressly listed in Tabella I since 5 March 2016. Under article 73, principal production, sale, supply and related conduct involving it without the authorization required by article 17 is punishable by six to twenty years' imprisonment and a fine of €26,000 to €260,000. Illicit import, export, purchase, receipt or possession exclusively for personal use is instead an administrative offence under article 75, carrying one or more specified administrative sanctions for two months to one year; personal-use possession is therefore not lawful.
References
Citations
- Suchtgiftverordnung; Suchtmittelgesetz. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40250737/NOR40250737.html1
- Royal Decree of 6 September 2017 regulating narcotic and psychotropic substances. ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
- Royal Decree of 6 September 2017 regulating narcotic and psychotropic substances. fagg.be (n.d.). https://www.fagg.be/sites/default/files/content/INSP/NARC/annex%20II_non%20official%20consolidated%20version.pdf1
- Resolução da Diretoria Colegiada ANVISA nº 1.036, de 9 de julho de 2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=RDC&numeroAto=00001036&seqAto=000&valorAno=2026&orgao=RDC/DC/ANVISA/MS&codTipo=&desItem=&desItemFim=&cod_menu=1696&cod_modulo=134&pesquisa=true1
- Resolução - RDC ANVISA nº 970, de 19 de março de 2025. in.gov.br (n.d.). https://www.in.gov.br/en/web/dou/-/resolucao-rdc-anvisa-n-970-de-19-de-marco-de-2025-*-6198972421
- Lista de substâncias sujeitas a controle especial no Brasil. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista-substancias1
- Controlled Drugs and Substances Act. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/FullText.html1
- 我国管制毒品目录（2026年7月更新，540种+三大类）. ga.sz.gov.cn (n.d.). https://ga.sz.gov.cn/SZJDZX/SZBMFW/content/post_12898420.html1
- 麻醉药品和精神药品管理条例 (Regulations on the Administration of Narcotic Drugs and Psychotropic Substances), third revision. xzfg.moj.gov.cn (n.d.). https://xzfg.moj.gov.cn/front/law/detail?LawID=17441
- 非药用类麻醉药品和精神药品列管办法 (Measures for Scheduling Non-Medicinal Narcotic Drugs and Psychotropic Substances). gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
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Recent changes7 human edits · latest
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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