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2-MeO-Ketamine

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
Harm Potential
Legality
2-MeO-Ketamine molecule structure2-MeO-Ketamine molecule structure
2-Methoxyketamine
Methoxyketamine, DinoKet, 2-MeO-2-deschloroketamine
Psychoactive Class
DissociativeHallucinogen
Chemical Class
Arylcyclohexylamine

2-MeO-Ketamine is a dissociative research chemical of the arylcyclohexylamine class, first reported in 1963. It is a structural analog of ketamine in which the chlorine atom has been replaced with a methoxy group. The substance produces sedative, dissociative, hallucinogenic, and at higher doses, anesthetic effects, though with lower potency than ketamine itself. It is considered extremely rare and potentially habit-forming.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold5-15 mg
Light15-60 mg
Moderate60-130 mg
Strong130+ mg

The 60-130 mg range is common, and the strong range is 130-200 mg+.

Duration

Onset10-20 minutes
After Effects2-4 hours
Total1-2 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow1 → orange1 → red1 → pink1
Mecke(ME)
white → yellow2 → orange2 → red2
Mandelin(MD)
yellow2 → red2 → brown2
Liebermann(LB)
white → brown2
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Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

2-MeO-Ketamine is a designer arylcyclohexylamine first reported in 1963. It is described as a ketamine analog in which ketamine's chlorine atom is replaced by a methoxy group.

Early report

The first report of 2-MeO-Ketamine dates to 1963, with synthesis work described as involving rearrangement of an amino ketone.

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: The Big & Dandy Methoxyketamine Thread
  2. Erowid: Ketamine Pharmacology and Dosage
  3. TripSit Factsheet: Methoxyketamine
  4. Wikipedia: 2-MeO-Ketamine

Further Reading

  1. Drugs-Forum: Methoxyketamine
  2. Roth et al. 2013 - The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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