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U-51754
U-51754 is a potent synthetic opioid and an analogue of U-47700. It is reported to act at the κ-opioid receptor, and on that basis is suspected of producing dysphoria and auditory hallucinations alongside its opioid effects.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Documentation of this compound's subjective effects is minimal. Reported κ-opioid activity has led to the suspicion that the experience carries a dysphoric character alongside auditory hallucination, though this remains unconfirmed rather than established from user accounts.
Cognitive
A dysphoric emotional tone is suspected rather than documented.
Auditory
Suspected rather than reported from experience accounts.
Pharmacology
Pharmacodynamics
U-51754 is a highly potent opioid reported to act at κ-opioid receptors, and this κ-opioid activity is suspected to underlie dysphoric and auditory hallucinatory effects. It is structurally an analogue of U-47700.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
History & Culture
Legality
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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