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Troparil
Troparil is a phenyltropane stimulant and dopamine reuptake inhibitor derived from methylecgonidine, first synthesized by Clarke and co-workers in the 1970s in an effort to separate cocaine's stimulant actions from its toxicity and dependence liability. It is several times more potent than cocaine at the dopamine transporter with a substantially longer duration, and the absence of an ester linkage removes local anaesthetic activity. Recreational use is extremely rare, as the compound is used almost exclusively in scientific research. It is suspected to be painful to insufflate.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
The drug is suspected to be painful to insufflate.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Troparil is described as a stimulant with effects resembling those of cocaine, but with a substantially longer duration of action. Unlike cocaine, it lacks local anaesthetic activity and is characterized as a pure stimulant. Recreational use has been extremely rare, so first-hand accounts of the experience are correspondingly scarce.
Physical
The primary reported effect is stimulation. Insufflation is suspected to be painful, as the compound does not numb the tissue it contacts.
Pharmacology
Pharmacodynamics
Troparil is a phenyltropane stimulant that acts as a dopamine reuptake inhibitor, and it is a few times more potent than cocaine at this target while being less potent as a serotonin reuptake inhibitor. It is the only regular phenyltropane whose affinity for the norepinephrine transporter exceeds its affinity for the dopamine transporter. Because the phenyl ring is bonded directly to the tropane ring through a non-hydrolyzable carbon-carbon bond rather than an ester linkage, troparil lacks the local anesthetic action of cocaine and behaves as a pure stimulant, with a duration of action a few times longer.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
History & Culture
Troparil was first synthesized by Clarke and co-workers in the 1970s, alongside the related compound WIN 35,428. Their stated aim was to isolate the stimulant properties of cocaine from its toxicity and its liability for dependence.…
Legality
Article Status
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Not yet reviewed — this article is pending editorial review by Lyrea.
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Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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