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TH-PVP
TH-PVP is a substituted cathinone derivative of the pyrovalerone class, structurally related to a-PVP and naphyrone. It has been sold as a designer drug and was first identified by a forensic laboratory in Hungary in 2015, subsequently appearing in Spain, Belgium, Poland, Turkey, and Brazil. Information on its effects and safety profile is limited, with little evidence of human use. It is considered habit-forming.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~10 mg
Light10-15 mg
Moderate15-25 mg
Strong25-35 mg
Heavy35+ mg
Subjective Effects
Subjective Effects not written up yet
Pharmacology
Pharmacodynamics
TH-PVP acts as a monoamine reuptake inhibitor rather than a releasing agent, with in vitro work showing no induction of monoamine release. Reported selectivity across studies differs: one found roughly 10-fold selectivity for serotonin over norepinephrine and dopamine, while another reported comparable potency at serotonin and dopamine with pronounced selectivity for both over norepinephrine. Despite this reuptake-inhibiting activity, TH-PVP did not produce stimulant effects in animals.
Pharmacokinetics
Absorption & half-lifenot documented yetMetabolitesnone documented yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance not written up yet
Harm Potential
Harm Potential not written up yet
History & Culture
TH-PVP was first identified by a forensic laboratory in Hungary in 2015, and has since been detected in a number of other countries, including Spain, Belgium, Poland, Turkey, and Brazil. It has been sold as a designer drug, though there is little evidence of human use and limited information available about its effects and safety profile.
Legality
Legality not written up yet
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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