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PRE-084

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
Harm Potential
History & Culture
Legality
PRE-084 molecule structurePRE-084 molecule structure
2-Morpholin-4-ylethyl 1-phenylcyclohexanecarboxylate
Fenclimorate
Psychoactive Class
NootropicAntidepressant
Chemical Class
Morpholine derivative

Dosage & Duration

Duration

Onset15-30 minutes
Total6-10 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → brown1
Mecke(ME)
white → brown2
Mandelin(MD)
yellow2 → brown2 → brown3
Liebermann(LB)
white → orange2
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Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: PRE-084 thread (22 mg sublingual report)
  2. Bluelight: PRE-084 thread (dose-conversion estimate approximately 1.5 mg)
  3. TripSit: Wiki - PRE-084
  4. Wikipedia

Further Reading

  1. Drugs-Forum Drug information: PRE-084
  2. Hong et al., sigma-1 receptor modulation of dopamine transporter (Nature, 2017)
  3. Hong et al., σ-1 receptor modulation of dopamine transporter (Nature, 2017)
  4. Hyrskyluoto et al., Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration
  5. LGC Standards - Chemical structure and IUPAC name for PRE-084
  6. Marra et al., pharmacokinetics of PRE-084 in mice (half-life ≈195 min)
  7. Marra et al., pharmacokinetics of PRE-084 in mice (half-life approximately 195 minutes)
  8. Maurice and Su, The Pharmacology of Sigma-1 Receptors
  9. MedChemExpress: PRE-084 hydrochloride profile
  10. PubChem: compound entry for PRE-084
  11. Reddit: r/Nootropics – Discussion of PRE-084 cognitive effects
  12. Reddit: r/researchchemicals – ‘I have PRE-084!’ (user plans 25-30 mg)
  13. Su et al., Sigma compounds derived from phencyclidine: identification of PRE-084
  14. Tocris - PRE-084 hydrochloride product sheet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

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