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Pentazocine
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
ModeratePentazocine is considered a habit-forming opioid depressant.
Toxicity
Pentazocine shares opioid adverse effects including drowsiness and respiratory depression; CNS depression can increase with other depressants.
Hallucinations, nightmares, delusions, and psychotomimetic effects are described as relatively frequent compared with many opioids.
At high doses, pentazocine can raise blood pressure or heart rate, and intravenous administration after myocardial infarction may add cardiac workload.
Multiple injections have caused severe injection-site necrosis and sepsis, sometimes requiring amputation; rare agranulocytosis, erythema multiforme, and toxic epidermal necrolysis are also reported.
Psychosis Risk
Pentazocine is described as fairly frequently causing hallucinations, nightmares, delusions, and psychotomimetic effects.
Seizure Risk
Pentazocine is among agents that reduce seizure threshold, but seizure frequency is not quantified.
History & Culture
Legality
International
Pentazocine is approved and vet approved.
By Country
References
Citations
- Controlled Drugs and Substances Act — Schedule I. laws-lois.justice.gc.ca (n.d.). https://www.laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html1
- Controlled Drugs and Substances Act — section 4. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-4.html1
- Controlled Drugs and Substances Act — section 5. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-5.html1
- Controlled Drugs and Substances Act — section 6. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-6.html1
- Controlled Drugs and Substances Act — section 7. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-7.html1
- Controlled Drugs and Substances Act — Coming into Force. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-8.html1
- Narcotic Control Regulations — Schedule. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/regulations/C.R.C.%2C_c._1041/FullText.html1
- Health Canada Drug Product Database — TALWIN tablet. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/info?code=18230&lang=eng1
- Health Canada Drug Product Database — pentazocine lactate search results. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/search-fast-recherche-rapide?lang=eng&no=01088520011
- 21 C.F.R. § 1308.14 — Schedule IV. ecfr.gov (n.d.). https://www.ecfr.gov/api/renderer/v1/content/enhanced/current/title-21?part=1308§ion=1308.141
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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