Parafluorofentanyl
Parafluorofentanyl is an extremely potent synthetic opioid and analogue of fentanyl, originally developed by Janssen Pharmaceutica during the 1960s. It is classified as a depressant with significant habit-forming potential. The substance remains rare, and relatively little is known about its pharmacological profile or safety margins. Due to its exceptional potency, it should be handled with extreme caution, and combining it with other depressants is strongly discouraged due to the heightened risk of fatal respiratory depression.
Contents
Dosage & Duration
Dosage
Subjective Effects
Reported effects are limited to those documented for fentanyl analogues generally, with itching and nausea noted alongside the potential for serious, life-threatening respiratory depression.
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
Parafluorofentanyl is an opioid analgesic and a structural analogue of fentanyl. Beyond its classification as an opioid analgesic, detailed pharmacodynamic characterization is not available in the current literature.
Pharmacokinetics
Tolerance
Opioids
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming.
Toxicity
As a fentanyl analog, it has contributed to numerous overdose deaths across Europe and the former Soviet republics since fentanyl analog use resurged in Estonia in the early 2000s.
Potentially serious respiratory depression can occur, which may be life-threatening.
History & Culture
Parafluorofentanyl was originally developed by Janssen Pharmaceutica during the 1960s as part of their extensive research into fentanyl analogs. The compound appeared briefly on the illicit United States market in the early 1980s, notably predating the introduction of the Federal Analog Act, which…
Legality
By Country
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the Parafluorofentanyl article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.