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Opium

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Opium molecule structureOpium molecule structure

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Moderate333-500 mg

Duration

After Effects1-12 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → purple2
Mecke(ME)
white → green2 → black3
Mandelin(MD)
yellow2 → brown3
Ehrlich(EH)
white → pink1
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Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Extremely High

Opium's addictive character is tied to mu-opioid receptor activity that increases dopamine release in the nucleus accumbens, and long-term use is repeatedly described as causing addiction.

Physical

Extremely High

Regular or long-term opium and morphine use can lead to tolerance and physical dependence.

Toxicity

respiratory and cardiovascular

Reported harms include hypoventilation, prolonged apnea, respiratory obstruction, respiratory difficulties, lung edema, coma, and cardiac or respiratory collapse.

endocrine and reproductive

Long-term opioid effects are linked to lower testosterone, loss of libido, impotence, amenorrhea, and infertility.

Carcinogenicity
Confirmed

Opium is described as having sufficient evidence for carcinogenicity in humans.

Evidence Basis
Human EpidemiologicalPositive

History & Culture

History & Culture not written up yet

Legality

International

Prohibited drug of abuse in most countries

Legal production exists in some countries for alkaloid extraction

By Country

Illegal2
United States flagUnited StatesIllegal
Canada flagCanadaIllegal

References

Citations

  1. Controlled Drugs and Substances Act — Schedule I. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html1
  2. Controlled Drugs and Substances Act — section 4. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-4.html1
  3. Controlled Drugs and Substances Act — section 5. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-5.html1
  4. Controlled Drugs and Substances Act — section 6. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-6.html1
  5. Controlled Drugs and Substances Act — section 7. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-7.html1
  6. Controlled Drugs and Substances Act — Coming into Force. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-8.html1
  7. Narcotic Control Regulations — Schedule. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/regulations/C.R.C.%2C_c._1041/page-14.html1
  8. Health Canada Drug Product Database — OPIUM TINCTURE. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/info?code=146&lang=eng1
  9. Health Canada Drug Product Database — OPIUM AND BELLADONNA SUP. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/info?code=15228&lang=eng1
  10. 21 C.F.R. § 1308.12—Schedule II (September 1, 2026). ecfr.gov (n.d.). https://www.ecfr.gov/api/renderer/v1/content/enhanced/2026-09-01/title-21?chapter=II&part=1308&subject_group=ECFRf62f8e189108c4d&section=1308.121

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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