Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
Opium
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Extremely HighOpium's addictive character is tied to mu-opioid receptor activity that increases dopamine release in the nucleus accumbens, and long-term use is repeatedly described as causing addiction.
Physical
Extremely HighRegular or long-term opium and morphine use can lead to tolerance and physical dependence.
Toxicity
Reported harms include hypoventilation, prolonged apnea, respiratory obstruction, respiratory difficulties, lung edema, coma, and cardiac or respiratory collapse.
Long-term opioid effects are linked to lower testosterone, loss of libido, impotence, amenorrhea, and infertility.
Opium is described as having sufficient evidence for carcinogenicity in humans.
History & Culture
Legality
International
Prohibited drug of abuse in most countries
Legal production exists in some countries for alkaloid extraction
By Country
References
Citations
- Controlled Drugs and Substances Act — Schedule I. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html1
- Controlled Drugs and Substances Act — section 4. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-4.html1
- Controlled Drugs and Substances Act — section 5. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-5.html1
- Controlled Drugs and Substances Act — section 6. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-6.html1
- Controlled Drugs and Substances Act — section 7. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-7.html1
- Controlled Drugs and Substances Act — Coming into Force. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-8.html1
- Narcotic Control Regulations — Schedule. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/regulations/C.R.C.%2C_c._1041/page-14.html1
- Health Canada Drug Product Database — OPIUM TINCTURE. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/info?code=146&lang=eng1
- Health Canada Drug Product Database — OPIUM AND BELLADONNA SUP. health-products.canada.ca (n.d.). https://health-products.canada.ca/dpd-bdpp/info?code=15228&lang=eng1
- 21 C.F.R. § 1308.12—Schedule II (September 1, 2026). ecfr.gov (n.d.). https://www.ecfr.gov/api/renderer/v1/content/enhanced/2026-09-01/title-21?chapter=II&part=1308&subject_group=ECFRf62f8e189108c4d§ion=1308.121
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the Opium article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.