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MiPT

MiPT molecule structureMiPT molecule structure
Chemical Class

MiPT is a tryptamine derivative structurally related to DMT.1 TiHKAL's commentary describes MiPT as producing almost no visual phenomena.2 It is active when taken orally.2 MiPT's synthesis was reported by Repke and colleagues in 19811 and later evaluated by Alexander Shulgin in TiHKAL. Unlike many tryptamine freebases, its freebase form does not rapidly decompose when exposed to light or oxygen.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~5 mg
Light5-10 mg
Moderate10-15 mg
Strong15-20 mg
Heavy20+ mg

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow3
Mandelin(MD)
yellow2 → yellow3
Liebermann(LB)
white → brown2
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

MiPT exhibited partial agonist activity at human 5-HT2A receptors in an in vitro calcium mobilization assay, with an EC50 of 44.9 ± 1.7 nM and an Emax of 74 ± 5%.3 It also binds to 5-HT1A and 5-HT2B receptors. Although it was a very poor inhibitor of [(3)H]paroxetine binding to SERT and of [(3)H]dihydrotetrabenazine binding to VMAT24, it does not inhibit monoamine reuptake or induce monoamine release, even at very high concentrations.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to MiPT's effects develops almost immediately after ingestion.
Baseline Reset
Tolerance returns to baseline after about 7 days without further use.
Half Tolerance
Tolerance falls to approximately half its initial level after about 3 days without further use.
Cross Tolerance

All psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

MiPT is not habit-forming, and the desire to use it may decrease with regular consumption.

Toxicity

Lethal Dosage

MiPT's exact toxic dose is unknown.

History & Culture

MiPT was first synthesized and described by David Repke and colleagues in 1981. Alexander Shulgin subsequently evaluated the substance and described it in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).…

Legality

International

Unscheduled in most countries

By Country

Illegal6
United States flagUnited StatesIllegal
Germany flagGermanyIllegal (analog/blanket ban)
Japan flagJapanIllegal
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomIllegal

References

Citations

  1. The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin. Acta Crystallographica Section E (2019). https://doi.org/10.1107/s2056989019011253123
  2. TiHKAL — #47. MIPT. Erowid Books Online — authorized TiHKAL reproduction (1997). https://www.erowid.org/library/books_online/tihkal/tihkal47.shtml12
  3. Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology (2014). https://doi.org/10.1007/s00213-014-3557-712
  4. Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of Neural Transmission (2009). https://doi.org/10.1007/s00702-009-0308-81
  5. Commission staff working paper on the assessment of the functioning of Council Decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive substances. European Commission — EUR-Lex (2011). https://eur-lex.europa.eu/legal-content/EN/TXT?uri=swd%3ASEC_2011_09121
  6. 指定薬物一覧(令和8年8月27日現在). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743040.pdf1
  7. 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律第二条第十五項に規定する指定薬物及び同法第七十六条の四に規定する医療等の用途を定める省令(平成十九年厚生労働省令第十四号), Article 1, item 54. elaws.e-gov.go.jp (n.d.). https://elaws.e-gov.go.jp/api/1/lawdata/419M600001000141
  8. 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律(昭和三十五年法律第百四十五号), Article 76-4. elaws.e-gov.go.jp (n.d.). https://elaws.e-gov.go.jp/api/1/articles;lawNum=%E6%98%AD%E5%92%8C%E4%B8%89%E5%8D%81%E4%BA%94%E5%B9%B4%E6%B3%95%E5%BE%8B%E7%AC%AC%E7%99%BE%E5%9B%9B%E5%8D%81%E4%BA%94%E5%8F%B7;article=%E7%AC%AC%E4%B8%83%E5%8D%81%E5%85%AD%E6%9D%A1%E3%81%AE%E5%9B%9B1
  9. 薬事法第2条第14項に規定する指定薬物及び同法第76条の4に規定する医療等の用途を定める省令の制定について(平成19年2月28日薬食発第0228006号). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/web/t_doc?dataId=00tb9834&dataType=1&pageNo=11
  10. Förordning (SFS 2026:1109) om ändring i förordningen (1992:1554) om kontroll av narkotika. svenskforfattningssamling.se (n.d.). https://svenskforfattningssamling.se/sites/default/files/sfs/2026-06/SFS2026-1109.pdf1

Further Reading

  1. Repke et al. 1985 - Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents

Article Status

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