Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
MiPT
MiPT is a tryptamine derivative structurally related to DMT.1 TiHKAL's commentary describes MiPT as producing almost no visual phenomena.2 It is active when taken orally.2 MiPT's synthesis was reported by Repke and colleagues in 19811 and later evaluated by Alexander Shulgin in TiHKAL. Unlike many tryptamine freebases, its freebase form does not rapidly decompose when exposed to light or oxygen.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Subjective Effects
Pharmacology
Pharmacodynamics
MiPT exhibited partial agonist activity at human 5-HT2A receptors in an in vitro calcium mobilization assay, with an EC50 of 44.9 ± 1.7 nM and an Emax of 74 ± 5%.3 It also binds to 5-HT1A and 5-HT2B receptors. Although it was a very poor inhibitor of [(3)H]paroxetine binding to SERT and of [(3)H]dihydrotetrabenazine binding to VMAT24, it does not inhibit monoamine reuptake or induce monoamine release, even at very high concentrations.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
All psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowMiPT is not habit-forming, and the desire to use it may decrease with regular consumption.
Toxicity
MiPT's exact toxic dose is unknown.
History & Culture
MiPT was first synthesized and described by David Repke and colleagues in 1981. Alexander Shulgin subsequently evaluated the substance and described it in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).…
Legality
International
Unscheduled in most countries
By Country
References
Citations
Further Reading
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed: this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the MiPT article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.