white → brown2
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WARNINGDANGER OF DEATH
High doses alone or ordinary doses in combination with other depressants can fatally stop breathing.
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Methoxyacetyl-Fentanyl
Methoxyacetyl-fentanyl is a highly potent synthetic opioid and fentanyl analogue classified as a depressant research chemical. Like other fentanyl analogues, it carries significant habit-forming potential. Its high potency presents serious overdose risks, as even minor dosing errors can prove fatal. Very limited information is available regarding its pharmacology and safety profile, making it an especially dangerous substance to use without proper harm reduction precautions.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~0.25 mg
Light0.25-0.5 mg
Moderate0.5-1.5 mg
Strong1.5+ mg
Duration
After Effects1-4 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Pharmacology
Pharmacodynamics
Methoxyacetylfentanyl is an opioid analgesic and a structural analog of fentanyl. While detailed receptor binding data for this compound has not been well characterized in the available literature, its classification as an opioid analgesic indicates activity at opioid receptors.
Pharmacokinetics
Absorption & half-lifenot documented yetMetabolitesnone documented yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Cross Tolerance
Opioids
Harm Potential
Addiction & Dependence
Psychological
HighClassified as habit-forming. As an opioid, it carries significant potential for psychological dependence.
Physical
HighAs an opioid classified as habit-forming, physical dependence with regular use is expected.
Toxicity
Respiratory
Potentially serious respiratory depression occurs during intoxication, which can be life-threatening; this risk is elevated at higher doses or when combined with other CNS depressants.
History & Culture
Methoxyacetylfentanyl, commonly abbreviated as MAF, emerged as part of a broader wave of synthetic opioid designer drugs that appeared on online markets during the 2010s. The substance belongs to a class of fentanyl analogs that have been associated with significant public health concerns across…
Legality
By Country
Illegal1
United StatesIllegalUnder United States federal law, methoxyacetyl fentanyl is listed by its exact name and chemical identity as a Schedule I controlled substance in 21 C.F.R. § 1308.11(b)(62), under DEA code 9825. The DEA first placed it temporarily in Schedule I on October 26, 2017, and made that placement permanent effective October 25, 2019. Federal possession, manufacture, distribution, import, export, research, and instructional use are unlawful unless authorized under the Controlled Substances Act and its registration framework; state, territorial, tribal, and local law may impose additional or different controls.
References
Citations
- Electronic Code of Federal Regulations, Title 21, § 1308.11 — Schedule I (September 1, 2026 text). ecfr.gov (n.d.). https://www.ecfr.gov/api/renderer/v1/content/enhanced/2026-09-01/title-21?part=1308§ion=1308.111
- Schedules of Controlled Substances: Temporary Placement of ortho-Fluorofentanyl, Tetrahydrofuranyl Fentanyl, and Methoxyacetyl Fentanyl Into Schedule I, 82 FR 49504. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/FR-2017-10-26/html/2017-23206.htm1
- Schedules of Controlled Substances: Placement of Cyclopropyl Fentanyl, Methoxyacetyl fentanyl, ortho-Fluorofentanyl, and para-Fluorobutyryl Fentanyl in Schedule I, 84 FR 57323. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/FR-2019-10-25/html/2019-23348.htm1
- DEA Lists of Scheduling Actions, Controlled Substances, and Regulated Chemicals (August 2026). deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf1
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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