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Metaxalone

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Metaxalone molecule structureMetaxalone molecule structure

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~400 mg
Light400-800 mg
Moderate800-1600 mg
Strong1600-2400 mg
Heavy2400+ mg

Duration

Onset15-45 minutes
After Effects1-8 hours
Total4-8 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Central Nervous System

CNS side effects including dizziness, headache, drowsiness, and irritability are commonly reported at therapeutic doses.

Gastrointestinal

Nausea and vomiting are common adverse effects associated with use.

History & Culture

History & Culture not written up yet

Legality

International

Metaxalone is approved.

By Country

Prescription1
United States flagUnited StatesPrescription only

References

Citations

  1. 21 U.S.C. § 353 — Exemptions and consideration for certain drugs, devices, and biological products. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?edition=prelim&num=0&req=granuleid%3AUSC-prelim-title21-section3531
  2. DailyMed — METAXALONE tablet (Direct_Rx; ANDA 203695). dailymed.nlm.nih.gov (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=45726fbc-3450-63f7-e063-6394a90a671a1
  3. DailyMed — SKELAXIN (metaxalone) tablet. dailymed.nlm.nih.gov (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7a4163f2-c553-4d14-7e98-d14c5c7f772a1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

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