WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged dependency, stopping suddenly can also cause seizures or delirium; seek medical help.
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Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
HighPsychological dependence may appear as craving or as feeling unable to manage daily life without the medication. People with prior sedative-hypnotic addiction may face greater risk.
Physical
HighLormetazepam can cause physical dependence, with benzodiazepine withdrawal symptoms emerging after dose reduction or discontinuation. This dependence is associated with altered GABA-BZD receptor-complex sensitivity. Withdrawal often resolves within 4-8 weeks, but about 10-15% of people may have symptoms for months, and rarely for years.
Toxicity
Residual effects after nighttime administration including sleepiness, impaired psychomotor and cognitive functions, and anterograde amnesia may persist into the next day; these effects are more pronounced in the elderly and may increase risks of falls.
Respiratory depression can occur, particularly in overdose or when combined with other CNS depressants; this effect may be life-threatening.
Jaundice has been reported as a side effect.
Blood disorders have been reported as a side effect.
Psychosis Risk
Paradoxical increase in aggression and confusion have been reported as side effects.
History & Culture
Legality
International
Lormetazepam is approved.
By Country
References
Citations
- Opiumwet — official consolidated BWB text in force from 9 July 2026, Lijst II. repository.officiele-overheidspublicaties.nl (n.d.). https://repository.officiele-overheidspublicaties.nl/bwb/BWBR0001941/2026-07-09_0/xml/BWBR0001941_2026-07-09_0.xml1
- Opiumwet, artikel 3 — prohibitions for Lijst II substances. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/jci1.3:c:BWBR0001941&artikel=3&z=2026-07-09&g=2026-07-091
- Opiumwet, artikel 5 — medical and lawful-acquisition exceptions. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/jci1.3:c:BWBR0001941&artikel=5&z=2026-07-09&g=2026-07-091
- Lormetazepam Aurobindo 2 mg, tabletten — Geneesmiddeleninformatiebank, College ter Beoordeling van Geneesmiddelen. geneesmiddeleninformatiebank.nl (n.d.). https://www.geneesmiddeleninformatiebank.nl/nl/rvg246581
- Staatsblad 1993, 449 — Wet van 2 juli 1993 tot wijziging van de Opiumwet in verband met het Verdrag inzake psychotrope stoffen. zoek.officielebekendmakingen.nl (n.d.). https://zoek.officielebekendmakingen.nl/stb-1993-449.pdf1
- Staatsblad 1994, 309 — commencement decree issued 3 May 1994. zoek.officielebekendmakingen.nl (n.d.). https://zoek.officielebekendmakingen.nl/stb-1994-309.pdf1
- MHRA: Marketing authorisations granted in September 2022. assets.publishing.service.gov.uk (n.d.). https://assets.publishing.service.gov.uk/media/633d2699e90e074401d7a6b0/Monthly_new_MA_listing_Sept_2022.pdf1
- MHRA Products: search results for lormetazepam. products.mhra.gov.uk (n.d.). https://products.mhra.gov.uk/search/?search=lormetazepam1
- The Human Medicines Regulations 2012, regulation 5 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2012/1916/regulation/51
- The Human Medicines Regulations 2012, regulation 214 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2012/1916/regulation/2141
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
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Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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