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Lormetazepam

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Lormetazepam molecule structureLormetazepam molecule structure
Chemical Class

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~0.5 mg
Light0.5-1 mg
Moderate1-2 mg
Strong2-4 mg
Heavy4+ mg

Duration

Onset10-30 minutes
After Effects1-24 hours
Total4-8 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

High

Psychological dependence may appear as craving or as feeling unable to manage daily life without the medication. People with prior sedative-hypnotic addiction may face greater risk.

Physical

High

Lormetazepam can cause physical dependence, with benzodiazepine withdrawal symptoms emerging after dose reduction or discontinuation. This dependence is associated with altered GABA-BZD receptor-complex sensitivity. Withdrawal often resolves within 4-8 weeks, but about 10-15% of people may have symptoms for months, and rarely for years.

Toxicity

Central Nervous System

Residual effects after nighttime administration including sleepiness, impaired psychomotor and cognitive functions, and anterograde amnesia may persist into the next day; these effects are more pronounced in the elderly and may increase risks of falls.

Respiratory

Respiratory depression can occur, particularly in overdose or when combined with other CNS depressants; this effect may be life-threatening.

Hepatic

Jaundice has been reported as a side effect.

Hematologic

Blood disorders have been reported as a side effect.

Psychosis Risk

Paradoxical increase in aggression and confusion have been reported as side effects.

History & Culture

History & Culture not written up yet

Legality

International

Lormetazepam is approved.

By Country

Illegal1
Netherlands flagNetherlandsIllegal
Prescription1
United Kingdom flagUnited KingdomPrescription only

References

Citations

  1. Opiumwet — official consolidated BWB text in force from 9 July 2026, Lijst II. repository.officiele-overheidspublicaties.nl (n.d.). https://repository.officiele-overheidspublicaties.nl/bwb/BWBR0001941/2026-07-09_0/xml/BWBR0001941_2026-07-09_0.xml1
  2. Opiumwet, artikel 3 — prohibitions for Lijst II substances. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/jci1.3:c:BWBR0001941&artikel=3&z=2026-07-09&g=2026-07-091
  3. Opiumwet, artikel 5 — medical and lawful-acquisition exceptions. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/jci1.3:c:BWBR0001941&artikel=5&z=2026-07-09&g=2026-07-091
  4. Lormetazepam Aurobindo 2 mg, tabletten — Geneesmiddeleninformatiebank, College ter Beoordeling van Geneesmiddelen. geneesmiddeleninformatiebank.nl (n.d.). https://www.geneesmiddeleninformatiebank.nl/nl/rvg246581
  5. Staatsblad 1993, 449 — Wet van 2 juli 1993 tot wijziging van de Opiumwet in verband met het Verdrag inzake psychotrope stoffen. zoek.officielebekendmakingen.nl (n.d.). https://zoek.officielebekendmakingen.nl/stb-1993-449.pdf1
  6. Staatsblad 1994, 309 — commencement decree issued 3 May 1994. zoek.officielebekendmakingen.nl (n.d.). https://zoek.officielebekendmakingen.nl/stb-1994-309.pdf1
  7. MHRA: Marketing authorisations granted in September 2022. assets.publishing.service.gov.uk (n.d.). https://assets.publishing.service.gov.uk/media/633d2699e90e074401d7a6b0/Monthly_new_MA_listing_Sept_2022.pdf1
  8. MHRA Products: search results for lormetazepam. products.mhra.gov.uk (n.d.). https://products.mhra.gov.uk/search/?search=lormetazepam1
  9. The Human Medicines Regulations 2012, regulation 5 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2012/1916/regulation/51
  10. The Human Medicines Regulations 2012, regulation 214 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2012/1916/regulation/2141

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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