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Loprazolam

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Legality
Loprazolam molecule structureLoprazolam molecule structure
Chemical Class

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~0.25 mg
Light0.25-0.5 mg
Moderate0.5-1.5 mg
Strong1.5-3 mg
Heavy3+ mg

Duration

Onset30-50 minutes
After Effects1-8 hours
Total6-10 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming with risk of psychological dependence developing with regular use. Abnormal, often severe drug-seeking behavior has been reported following abrupt withdrawal from long-term use.

Physical

High

Physical dependence develops with regular use, though risk is low if used for less than 4 weeks or very occasionally. Between 30% and 90% of long-term users experience withdrawal symptoms upon discontinuation. Withdrawal symptoms tend to last between 3 weeks to 3 months, with 10-15% experiencing protracted withdrawal persisting for many months or occasionally several years.

Toxicity

Central Nervous System

Regular use can cause cognitive and psychomotor impairments including drowsiness, confusion, amnesia, ataxia, and impaired balance that may persist into the next day; higher doses may impair long-term memory functions.

Hepatic

Jaundice has been reported as a side effect, suggesting potential hepatic involvement with use.

Hematologic

Blood disorders have been reported as a side effect.

Psychosis Risk

Moderate

Psychosis, confusion, and visual and auditory hallucinations with delusions can occur as major complications following abrupt or rapid withdrawal, especially from high doses. Paradoxical increase in aggression may also occur during use.

Seizure Risk

Moderate

Epileptic seizures, which may be fatal, can occur as a major complication after abrupt or rapid withdrawal, especially from high doses. Gradual dose reduction greatly minimizes this risk.

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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