Kanna
Kanna (Sceletium tortuosum) is a succulent plant native to South Africa that has been used by indigenous Khoisan peoples for thousands of years, traditionally fermented and chewed for its psychoactive effects.citation needed The first written account dates to 1662. Containing alkaloids such as mesembrine, kanna produces anxiolytic, mood-enhancing, and mildly euphoric effects primarily through serotonin reuptake inhibition and PDE4 inhibition. It is also reported to suppress appetite1 and enhance cannabis effects.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Insufflation is not recommended. Snorting raw plant material has been described as extremely painful and damaging to the nasal cavity, causing immediate burning and watering of the eyes. Concentrated extracts have been reported to cause less irritation than raw leaf material.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Kanna produces a mild, short-lived inebriation that gives way to a relaxed, sedated state with a positive emotional tone. Insufflation brings on effects within seconds, holding at a stable plateau for roughly ten to twenty minutes before tapering into a distant sedation that can leave a pleasant, relaxed afterglow lasting some hours. The character is intoxicating in a slightly disorientated, mildly drunk way, but without a corresponding loss of mental clarity. Oral use produces a gentler psychoactive effect described as a positive vibe carrying across the following few hours.
Physical
The body experience is light, with reports of no nausea and no body load; sedation and relaxation dominate, and appetite and thirst suppression are described in traditional use.
Cognitive
The headspace shifts quickly toward mild intoxication and disorientation while remaining lucid, with anxiety reduction, stress relief, and mild euphoria commonly described.
Emotional
Auditory
Music appreciation is reported as heightened, extending to genres not normally enjoyed.
Pharmacology
Pharmacodynamics
Kanna acts primarily as a monoamine releaser through upregulation of vesicular monoamine transporter-2 (VMAT-2)citation needed, with serotonin reuptake inhibition serving as a secondary mechanism. The plant also exhibits phosphodiesterase-4 (PDE4) inhibition, which may contribute to its mood-enhancing and cognitive effects. Additional pharmacological activities include mild inhibition of acetylcholinesterase and monoamine oxidase-A, CB1 receptor antagonism, and CYP17A1 inhibition. Fermented preparations show synergistic effects among alkaloids in CB1 receptor and acetylcholinesterase inhibition that exceed those of mesembrine alone.
Pharmacokinetics
Kanna contains approximately 1 to 1.5% total alkaloids, with mesembrine being the most prominent.citation needed Traditional fermentation transforms mesembrine into delta-7 mesembrenone while reducing oxalate content. Fermented extracts demonstrate greater bioavailability and efficacy, particularly through mucosal absorption routes. Mesembrine transforms into mesembrenone when exposed to sunlight and aqueous conditions but remains stable in methanol or darkness.3
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
LowClassified as habit-forming, though specific patterns of psychological dependence are not well characterized in the available literature.
Toxicity
Insufflation causes significant irritation and damage to the nasal cavity; this route of administration is not recommended.
History & Culture
Traditional Use
Plants of the genus Sceletium have likely been used for millennia by the San and Khoi peoples of South Africa as masticatories and traditional medicines.4 The indigenous Khoisan peoples traditionally fermented and chewed the plant as kougoed, an Afrikaans term meaning…
Legality
International
The official INCB editions of the 1961 and 1971 conventions, including their schedules, and the 1988 convention including its tables were fetched and inspected. No occurrence of kanna, Sceletium tortuosum, mesembrine or mesembrenone was observed in those schedules/tables. This international result does not determine national generic-law or analogue coverage.
By Country
References
Citations
- Olatunji TL, & Afolayan AJ. (2021). Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities. 280, Article 114476. https://doi.org/10.1016/j.jep.2021.1144761
- Harvey AL, Young LC, Viljoen AM, & Gericke NP. (2011). Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids. 137(3), 1124–1129. https://doi.org/10.1016/j.jep.2011.07.03512
- Patnala S, & Kanfer I. (2009). Investigations of the phytochemical content of Sceletium tortuosum following the preparation of 'Kougoed' by fermentation of plant material. 121(1), 86–91. https://doi.org/10.1016/j.jep.2008.10.0081
- Gericke N, & Viljoen AM. (2008). Sceletium—A review update. 119(3), 653–663. https://doi.org/10.1016/j.jep.2008.07.0431234
- Gouhie FA, Rodrigues JPA, Vieira LF, & Cunha CLN. (2023). Sceletium tortuosum effects on anxiety: A systematic review and meta-analysis. 11, Article 100092. https://doi.org/10.1016/j.dscb.2023.1000921
- Biosecurity and Agriculture Management Act 2007 (WA), s 11 (WAOL). dpird.wa.gov.au (n.d.). https://www.dpird.wa.gov.au/Organism/TaxonDetails/105566/Sceletium1
- Biosecurity and Agriculture Management Act 2007 (WA), s 11 (WAOL). legislation.wa.gov.au (n.d.). https://www.legislation.wa.gov.au/legislation/prod/filestore.nsf/FileURL/mrdoc_49440.htm/$FILE/Biosecurity%20and%20Agriculture%20Management%20Act%202007%20-%20%5B02-i0-00%5D.html?OpenElement1
- Royal Decree of 31 August 2021 on the manufacture and trade of foods composed of or containing plants or plant preparations. ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/cgi_loi/article.pl?language=fr&lg_txt=f&type=&sort=&numac_search=&cn_search=2021083110&caller=eli&&view_numac=2021083110nl1
- Royal Decree of 31 August 2021 on the manufacture and trade of foods composed of or containing plants or plant preparations. health.belgium.be (n.d.). https://www.health.belgium.be/fr/professionnels/entreprises/produits-consommation/alimentation/aliments-specifiques/complements-alimentaires-aliments-enrichis/plantes-complements-alimentaires1
- Royal Decree of 31 August 2021 on the manufacture and trade of foods composed of or containing plants or plant preparations. health.belgium.be (n.d.). https://www.health.belgium.be/sites/default/files/media/files/2026-03/list_1.pdf1
Article Status
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Recent changes8 human edits · latest
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14 August 2026
Lyrea · Updated the article
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Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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