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K-2c-B
βk-2C-B is a research chemical with psychedelic and empathogenic properties. As a beta-keto derivative of 2C-B, it produces notably longer-lasting effects, with roughly double the duration of its parent compound. The substance is known for its unpredictable effectiveness, which can make reliable dosing difficult. It is also inactivated by high pH environments, a property that may be relevant to route of administration considerations.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Dosing data for this substance remains preliminary and incomplete. Users should note that available documentation indicates a significant gap between the light and moderate dose thresholds, suggesting a steep dose-response curve that warrants additional caution. Independent research is strongly advised before use.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
K-2c-B has been reported as a low-potency partial agonist at serotonin 5-HT2A receptors. Published assay values include EC50 estimates around 905 nM with 41% maximal efficacy, and another reported 5-HT2A EC50 of 6,732 nM, both far weaker than comparator compounds such as 2C-B, 2C-I, or 2C-E. It also shows weak MAO-B inhibition at about 14,000 nM IC50, while MAO-A inhibition was not detected.
Pharmacokinetics
The available pharmacology quote material does not provide human pharmacokinetic parameters for K-2c-B.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Toxicity
Insufflation is reported to be not well-tolerated, suggesting potential for local irritation or discomfort via this route.
History & Culture
βk-2C-B was first described in the scientific literature by Richard Glennon and colleagues in 2004. Despite being the β-keto derivative of the well-known psychedelic 2C-B, the compound was not included or mentioned in Alexander Shulgin's seminal work PiHKAL (Phenethylamines I Have Known and Loved).…
Legality
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
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Not yet reviewed — this article is pending editorial review by Lyrea.
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Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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